[1]肖光军,刘艳婷,杨 洪,等.四川省遂宁地区表观健康成年人群血浆FMN,FMN/TP比值及FMN/ALB比值参考区间的建立[J].现代检验医学杂志,2019,34(02):56-59.[doi:10.3969/j.issn.1671-7414.2019.02.015]
　XIAO Guang-jun,LIU Yan-ting,YANG Hong,et al.Establishment of Reference Interval for PlasmaFMN,FMN/TP and FMN/ALB Value among Apparently HealthyAdult Population in Suining of Sichuan[J].Journal of Modern Laboratory Medicine,2019,34(02):56-59.[doi:10.3969/j.issn.1671-7414.2019.02.015]
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四川省遂宁地区表观健康成年人群血浆FMN,FMN/TP比值及FMN/ALB比值参考区间的建立()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
56-59
栏目:
论著
出版日期:
2019-05-11

文章信息/Info

Title:
Establishment of Reference Interval for PlasmaFMN,FMN/TP and FMN/ALB Value among Apparently HealthyAdult Population in Suining of Sichuan
文章编号:
1671-7414(2019)02-056-05
作者:
肖光军; 刘艳婷; 杨 洪; 李祥坤; 杨 娜; 曹 丹; 陈小冬
(遂宁市中心医院检验科,四川遂宁 629000)
Author(s):
XIAO Guang-jun; LIU Yan-ting; YANG Hong; LI Xiang-kun; YANG Na; CAO Dan; CHEN Xiao-dong
(Department of Clinical Laboratory,Suining Central Hospital,Sichuan,Suining 629000,China)
关键词:
血浆;  果糖胺;  果糖胺/总蛋白比值;  果糖胺/清蛋白比值;  参考区间
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2019.02.015
文献标志码:
A
摘要:
目的 建立四川省遂宁地区表观健康成年人群血浆果糖胺(fructosamine,FMN)、果糖胺/总蛋白比值(fructosamine to total protein ratio,FMN/TP)及果糖胺/清蛋白比值(fructosamine to albumin ratio,FMN/ALB)的参考区间。方法 选取2017年1～12月遂宁市中心医院健康管理中心14 639例20～79岁的表观健康成年人作为研究对象,其中男性4 811例,女性9 828例,通过问卷调查、体格检查、超声及实验室检查排除呼吸系统、血液系统、内分泌系统、炎症和肿瘤等疾病,检测其血浆FMN、总蛋白(total protein,TP)和清蛋白(albumin,ALB)的浓度并计算该人群FMN/TP及FMN/ALB的浓度水平。根据性别和年龄将研究对象分组(男女各6组:20～29岁组,30～39岁组,40～49岁组,50～59岁组,60～69岁组和70～79岁组),对各组检测结果进行统计学分析,浓度水平差异无统计学意义的各组数据进行合并后,呈正态分布则以均值±1.96标准差((-overx)&#177;1.96s)建立该地区表观健康人群血浆中FMN,FMN/TP及FMN/ALB的参考区间; 呈偏态分布以百分位数法(P2.5～P97.5)建立其参考区间。结果 男性血浆FMN,FMN/TP及FMN/ALB浓度水平依次为1.7(1.6～1.8)mmol/L,22.0(20.7～23.5)μmol/g和37.1(34.5～39.8)μmol/g; 女性则依次为1.7(1.6～1.8)mmol/L,22.4(21.1～23.9)μmol/g和38.5(36.2～41.2)μmol/g。男性和女性血浆FMN,FMN/TP及FMN/ALB浓度水平均呈偏态分布(P<0.05),且两组间比较差异均具有统计学意义(P<0.01)。进一步分析,男性和女性各年龄组血浆FMN,FMN/TP及FMN/ALB浓度水平的中位数与其总体区间中位数的差异均<25%,故不建议按年龄段分组建立参考区间,可仅按性别分组建立其参考区间。 FMN的参考区间:男性为1.4～2.0 mmol/L,女性为1.5～2.0 mmol/L; FMN/TP的参考区间:男性为18.2～26.4 μmol/g,女性为18.9～26.8 μmol/g; FMN/ALB的参考区间:男性为30.4～46.1 μmol/g,女性为32.1～46.9 μmol/g。结论 初步建立了遂宁地区20～79岁表观健康人群血浆FMN,FMN/TP及FMN/ALB的参考区间,为临床应用其作为糖尿病患者的诊断及疗效评估指标提供依据。
Abstract:
Objective To establish the reference intervalsof fructosamine(FMN),fructosamine to total protein ratio(FMN/TP)and fructosamine to albumin ratio(FMN/ALB)in peripheral blood plasma of apparently healthy adult population in Suining of Sichuan.Methods FromJanuary to December 2017,14 639 apparent healthy adults aged 20 to 79 years old in the Health Management Center of Suining Central Hospital were selected as the research objects,including 4 811 males and 9 828 females.Through questionnaire survey,physical examination,ultrasound and laboratory examination,diseases such as respiratory system,blood system,endocrine system,inflammation and tumor were excluded from the research objects.And then detected the concentration of plasma FMN,TP,ALB,and calculated standard of the concentration about FMN/TP and FMN/ALB.The subject were grouped that according to gender and age(divided into six age groups for men and women:20～29 years old group,30～39 years old group,40～49 years old group,50～59 years old group,60～69 years old group,70～79 years old group).The results were statistically analyzed.The data of each group that with none statistically significant difference in concentration level would be combined.If the data of group in normal distribution,the reference intervals of FMN,FMN/TP and FMN/ALB in plasma of the apparently healthy population in this region were established with mean ±1.96s standard deviation((-overx)&#177;1.96s).In skewed distribution,established reference interval were established by percentiles(P2.5～P97.5).Results The concentration level of plasma FMN,FMN/TP and FMN/ALB were 1.7(1.6～1.8)mmol/L,22.0(20.7～23.5)μmol/g,37.1(34.5～39.8)μmol/g for men,(34.5～39.8)μmol/g,1.7(1.6～1.8)mmol/L,22.4(21.1～23.9)μmol/g and 38.5(36.2～41.2)μmol/g for women,respectively.The concentrations level of FMN,FMN/TP and FMN/ALB in male and female plasma presented by skewed distribution(P<0.05),and the difference between two groups was statistically significant(P<0.01).Further analysis,difference value were <25%,between the age group median and the overall intervals median in plasma concentration of FMN,FMN/TP and FMN/ALB in the male &females.Therefore,shouldn't advise to establish reference interval by range of ages.Could established reference interval by gender.The reference interval with FMN:1.4～2.0 mmol/L for men and 1.5～2.0 mmol/L for women.The reference interval of FMN/TP:18.2～26.4 μmol/g for men and 18.9～26.8 μmol/g for women,and the reference interval of FMN/ALB:30.4～46.1 μmol/g for men and 32.1～46.9 μmol/g for women.Conclusion The reference ranges of plasma FMN,FMN/TP and FMN/ALB in the apparently healthy population aged 20～79 in Suining region have been preliminarily established,which provides a basis of clinical application for diagnosis and therapy in diabetic patients.

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备注/Memo

备注/Memo:
作者简介:肖光军(1986-),男,本科,医学学士学位,主管检验师,主要从事临床检验医学的研究。 通讯作者:李祥坤,E-mail: 694989821@qq.com。 收稿日期:2018-09-17 修回日期:2019-03-06 页码：59+63
更新日期/Last Update: 2019-04-30