[1]陈小娟a,邱敏娟a,高 飞a,等.广州地区孕妇尿碘水平与甲状腺功能减退的相关性分析[J].现代检验医学杂志,2019,34(02):119-121.[doi:10.3969/j.issn.1671-7414.2019.02.030]
 CHEN Xiao-juana,QIU Min-juana,GAO Feia,et al.Analysis of the Correlation between Urinary Iodine Leveland Hypothyroidism in Pregnant Women in Guangzhou[J].Journal of Modern Laboratory Medicine,2019,34(02):119-121.[doi:10.3969/j.issn.1671-7414.2019.02.030]
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广州地区孕妇尿碘水平与甲状腺功能减退的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
119-121
栏目:
检验与临床
出版日期:
2019-05-11

文章信息/Info

Title:
Analysis of the Correlation between Urinary Iodine Leveland Hypothyroidism in Pregnant Women in Guangzhou
文章编号:
1671-7414(2019)02-119-04
作者:
陈小娟a邱敏娟a高 飞a李 飞b郑 浩a蔡敏敏a
(广州市妇女儿童医疗中心a.珠江新城院区检验科; b.产前诊断科,广州 510623)
Author(s):
CHEN Xiao-juanaQIU Min-juanaGAO FeiaLI FeibZHENG HaoaCAI Min-mina
(a.Department of Clinical Laboratory,Zhujiang New Town; b.Department of Prenatal Diagnosis,Guangzhou Women and Children's Medical Center,Guangzhou 510623,China)
关键词:
妊娠 尿碘 甲状腺功能
分类号:
R714.147; R446.122
DOI:
10.3969/j.issn.1671-7414.2019.02.030
文献标志码:
A
摘要:
目的 分析广州地区妊娠期妇女的碘营养状况,探讨其与甲状腺功能减退的关系。方法 随机选取2017年1~12月于广州市妇女儿童医疗中心产科门诊进行产检的孕妇4 986例,对其空腹血清促甲状腺激素(TSH)、游离甲状腺激素(FT4)、甲状腺过氧化物酶抗体(TPOAb)及尿碘(UI)水平进行回顾性分析。结果 4 896例孕妇尿碘水平为5~1 476 μg/L,中位数为179.3 μg/L,碘缺乏、碘适量、碘超足量和碘过量的发生率分别为39.93%,28.42%,18.99%和12.66%。随着尿碘水平的升高,TSH和FT4水平随之升高,差异具有统计学意义(χ2=20.19,P=0.001; χ2=16.45,P=0.000); 三组甲状腺功能异常在不同碘营养状态的发生率差异无统计学意义(χ2=4.08,P=0.67); TPOAb的阳性率为24.11%,其在三组甲状腺疾病中的阳性率差异具有统计学意义(χ2=10.18,P=0.006)。结论 广州地区妊娠期碘不足或碘过量较为常见,维持适量的尿碘水平对预防甲状腺功能异常有重要意义。
Abstract:
Objective To investigate the association of urinary iodine nutritional of pregnant women with hypothyroidism in Guangzhou.Methods A total of 4 986 pregnant women were enrolled from January 2017 to December,and retrospectively analyzed their urinary iodine level(UI)and thyroid function index(included TSH,FT4 and TPOAb).Results The range of urine iodine level in pregnant women was 5~1 476 μg/L,the urine iodine median was 179.3 μg/L,the iodine deficiency,iodine in moderation,iodine adequate enough,and the incidence of iodine excess were 39.93%,28.42%,18.99% and 12.66%,respectively.With the increase of urinary iodine,the levels of TSH and FT4 increased,and the difference was statistically significant(χ2=20.19,P=0.001; χ2=16.45,P=0.000).The incidence of hypothyroidism,subclinical hypothyroidism and low thyroid hormone levels were 0.14%,0.62% and 2.05%,respectively.Compared three groups of thyroid disease incidence in different urinary iodine levels,there was no statistically significant(χ2=4.08,P=0.67).The positive rate of TPOAb was 24.11%,and compared the positive rate of TPOAb between three group thyroid disease,there was statistically significant(χ2=10.18,P=0.006).Conclusion Iodine deficiency or excess during pregnancy is common in Guangzhou.Maintaining adequate urinary iodine level is of great significance in preventing thyroid dysfunction.

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备注/Memo

备注/Memo:
作者简介:陈小娟(1973-),女,本科,副主任技师,从事临床生化专业,E-mail:cxjandhzx@163.com。 收稿日期:2018-09-26 修回日期:2019-01-19 页码:121+124
更新日期/Last Update: 2019-04-30