[1]池继敏,邹 明,黄玉霞,等.少年儿童骨科疾病患者血清骨代谢标志物浓度探讨[J].现代检验医学杂志,2019,34(02):125-129.[doi:10.3969/j.issn.1671-7414.2019.02.032]
　CHI Ji-min,ZOU Ming,HUANG Yu-xia,et al.Study on Serum Bone Metabolic Markers Concentrationin Children with Orthopedic Diseases[J].Journal of Modern Laboratory Medicine,2019,34(02):125-129.[doi:10.3969/j.issn.1671-7414.2019.02.032]
点击复制

少年儿童骨科疾病患者血清骨代谢标志物浓度探讨()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
125-129
栏目:
检验与临床
出版日期:
2019-05-11

文章信息/Info

Title:
Study on Serum Bone Metabolic Markers Concentrationin Children with Orthopedic Diseases
文章编号:
1671-7414(2019)02-125-05
作者:
池继敏; 邹 明; 黄玉霞; 唐 敏
(四川省骨科医院检验科,成都 610041)
Author(s):
CHI Ji-min; ZOU Ming; HUANG Yu-xia; TANG Min
(Department ofClinical Laboratory,Sichuan Orthopedic Hospital,Chengdu 610041,China)
关键词:
少年儿童;  骨钙素;  β-胶原特殊序列
分类号:
R726.8; R446.11
DOI:
10.3969/j.issn.1671-7414.2019.02.032
文献标志码:
A
摘要:
目的 探讨不同性别不同年龄少年儿童骨科疾病患者血清骨代谢标志物浓度变化,了解骨钙素及β-胶原特殊序列两项指标在少年儿童期受性别及年龄的影响程度。方法 选取2013年1月～2018年6月四川省骨科医院收治的少年儿童骨科疾病住院患者1 179例,年龄1～18岁。按性别及年龄分组,年龄段以每一岁为一个年龄段划分,分别测定血清骨钙素及β-胶原特殊序列浓度,并比较二者在相同年龄不同性别下的浓度差异以及相同性别不同年龄下的浓度变化趋势。结果 相同年龄不同性别比较,1～9岁和11岁时,男女骨钙素和β-胶原特殊序列浓度差异无统计学意义(t=0.032～1.936,t=0.046～1.307,均P>0.05); 10岁时,女性骨钙素浓度高于男性(117.15±44.63 ng/ml vs 85.12±29.48 ng/ml),差异有统计学意义(t=2.508,P=0.017); 12～18岁时,男性骨钙素和β-胶原特殊序列浓度均明显高于女性,差异有统计学意义(t=3.318～7.986,t=3.317～9.381,均P<0.01)。另一方面,从变化趋势上看,血中骨钙素及β-胶原特殊序列浓度均随着年龄的增长前期呈上升趋势,二者浓度男性在12～13岁时达到峰值,女性在11岁时达到峰值,之后均逐渐下降。结论 少年儿童骨科疾病患者血清骨钙素及β-胶原特殊序列浓度受年龄及性别影响较大,随着年龄的增长,二者在血中的浓度变化趋势具有一致性,诊断和治疗时应充分考虑年龄和性别因素。
Abstract:
Objective To investigate the changes of serum bone metabolic markers in children with orthopedic diseases of different gender and ages, and understand the extent of osteocalcin and β-crosslaps in children affected by gender and age.Methods Extract sourcesfrom January 2013 to June 2018,which included 1 179 patients,age from 1～18 with orthopedic diseases admitted to Sichuan Orthopedic Hospital were selected and grouped according to gender and age.The age was divided into distinctive agegroups for every one year gap.The concentrations of serum osteocalcin and β-crosslaps were measured respectively.The concentration difference between them was compared under the same age and different gender.At the same time,the concentration change trends of the same gender and different ages were analyzed.Results At 1～9 years old and 11 years old,there was no significant difference in osteocalcin and β-crosslaps(t=0.032～1.936,t=0.046～1.307,all P>0.05).At 10 years old,the female's osteocalcin concentration was higher than that in Male(117.15±44.63 ng/ml vs 85.12±29.48 ng/ml),the difference was statistically significant(t=2.508,P=0.017).At 12～18 years old,the concentrations of osteocalcin and β-crosslaps in male were significantly higher than that in female,the difference statistically significant(t=3.318～7.986,t=3.317～9.381,all P<0.01).On the otherhand,from the trend of change,the concentrations of osteocalcin and β-crosslaps increased with the increase of age.The concentrations of male peaked at 12～13 years old,female at 11 years old,and then both of them gradually decreased.Conclusion The concentrations of serum osteocalcinand β-crosslaps in children with orthopedic diseases was significantly affected by age and gender.With the increase of age,the trends of concentration change in blood were consistent,Therefore,age and gender should be fully consideredduring the diagnosis and treatment.

参考文献/References:

[1] 陈旭,余进伟,赵运亮,等.膝关节关节液和血清中骨钙素、基质金属蛋白酶1及胰岛素样生长因子Ⅰ含量与软骨损伤关系的初步研究[J].中医正骨,2016,28(2):20-22. CHEN Xu,YU Jinwei,ZHAO Yunliang,et al.A pilot study on the relationship between knee cartilage injury and contents of bone gla protein,matrix metalloproteinase 1 and insulin-like growth factorⅠin knee synovial fluid and serum[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(2):20-22.
[2] 李振.老年女性骨质疏松患者血清中白细胞介素-6,-8,骨钙素和雌二醇的表达及意义[J].中国老年学杂志,2016,36(13):3273-3275. LI Zhen.Expression and significance of elderly wo-men with osteoporosis in patients with serum interleukin-6,-8,osteocalcin and estradiol[J].Chinese Journal of Gerontology,2016,36(13):3273-3275.
[3] 李永念,姚加平.老年女性骨质疏松症患者血清BGP,CT,E2,Ca和P检测的临床意义[J].放射免疫学杂志,2013,26(3):267-269. LI Yongnian,YAO Jiaping.Clinical significance of measurement the changes on serum BGP,CT,E2,Ca and P levels in patients with elderly women osteoporosis[J].Journal of Radioimmanology,2013,26(3):267-269.
[4] 陈文军.老年骨质疏松性骨折患者血清BGP,BALP,TRACP-5b表达的价值研究[J].国际检验医学杂志,2018,39(15):1870-1872. CHEN Wenjun.The value of serum osteocalcin,B-ALP and TRACP-5b expression in elderly patients with osteoporotic fracture[J].International Journal of Laboratory Medicine,2018,39(15):1870-1872.
[5] 杨先甲,胡建斌,汪亚玲.老年糖尿病骨质疏松性骨折患者血清生化指标的检测研究[J].海南医学院学报,2018,24(15):1431-1434. YANG Xianjia,HU Jianbin,WANG Yaling.Detection of serum biochemical indexes in elderly patients with type 2 diabetes mellitus with osteoporotic fracture[J].Journal of Hainan Medical University,2018,24(15):1431-1434.
[6] 闫玉珠,赵和平,王冀邯,等.骨质疏松患者抗苗勒管激素与骨标志物和雌激素的相关性研究[J].现代检验医学杂志,2017,32(5):78-82. YAN Yuzhu,ZHAO Heping,WANG Jihan,et al.AMH in osteoporosis:Correlation with bone biochemical markers and estrogen[J].Journal of Modern Laboratory Medicine,2017,32(5):78-82.
[7] 杨媛慧,杜静,陈卫东.骨质疏松症患者骨代谢生化指标检测的临床意义[J].现代检验医学杂志,2014,29(3):27-29. YANG Yuanhui,DU Jing,CHEN Weidong.Clinical biochemical markers ofbone metabolism in patients with osteoporosis[J].Journal of Modern Laboratory Medicine,2014,29(3):27-29.
[8] 冯建军,邹浩,朱海燕,等.槲皮素对去卵巢大鼠血清骨钙素和股骨Ⅰ型胶原蛋白水平的影响[J].中医正骨,2016,28(7):10-13. FENG Jianjun,ZOU Hao,ZHU Haiyan,et al.Effect of quercetin on serum osteocalcin levels and femur type Ⅰ collagen protein levels in the ovariectomized rats[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(7):10-13.
[9] ROSENQUIST C, FLEDELIUS C, CHRISTGAU S,et al.Serum crossLaps one step ELISA first application of monoclonal antibodies for measurement in serum ofbone-related degradation products from C-terminal telopetides of type Ⅰ collagen[J].Clin Chem,1998,44(11):2281-2289.
[10] 黄江渝,胡汶竹.血清骨钙素水平检测的临床应用现状[J].现代预防医学,2007,34(9):1674-1675.HUANG Jiangyu,HU Wenzhu.Clinical application of serum osteocalcin level[J].Modern Preventive Medicine,2007,34(9):1674-1675.
[11] 吴慧平,金献江,罗越,等.血清基质金属蛋白酶2与骨代谢标志物水平对女童特发性中枢性性早熟的诊断价值研究[J].中国全科医学,2015,18(11):1264-1269.WU Huiping,JIN Xianjiang,LUO Yue,et al.Diagnosis value of the MMP-2 and bone metabolism markers in girls with idiopathic central precocious puberty[J].Chinese General Practice,2015,18(11):1264-1269.
[12] 田广,陈雪萍,康朝胜.3～6岁儿童血浆β-胶原特殊序列和N端中段骨钙素变化规律探讨[J].中国骨质疏松杂志,2015,21(1):25-28,43.TIAN Guang,CHEN Xueping,KANG Chaosheng.The role of plasma beta-crosslaps and N-mid fragment of osteocalcin in healthy 3-6-year-old children[J].Chinese Journal of Osteoporosis,2015,21(1):25-28,43.
[13] YANG Liju,GREY V.Pediatric reference intervals for bone markers[J].Clin Biochem,2006,39(6):561-568.
[14] 王平,王红梅,温友峰,等.藏族青少年骨碱性磷酸酶与骨钙素水平分析[J].中国公共卫生,2007,23(2):136-137.WANG Ping,WANG Hongmei,WEN Youfeng,et al.Study on serum BAP and OC oftibetan adolescen[J].Chinese Journal of Public Health,2007,23(2):136-137.
[15] 谢而付,张巧娣,蒋理,等.血清骨钙素与骨密度检测在中老年健康体检者中的应用及相关性分析[J].现代检验医学杂志,2014,29(6):41-43.XIE Erfu,ZHANG Qiaodi,JIANG Li,et al.Application of bone gamma-carboxyglutamic-acid-containing protein(BGP)in middle-aged and elder people's health care[J].Journal of Modern Laboratory Medicine,2014,29(6):41-43.

备注/Memo

备注/Memo:
作者简介:池继敏(1979-),女,本科,学士学位,副主任技师,主要研究方向:临床生化和骨代谢,E-mail:565092843@qq.com。 收稿日期:2018-06-18 修回日期:2019-03-03
更新日期/Last Update: 2019-04-30