[1]刘倩倩,刘兴晖,王海明,等.2型糖尿病患者血糖控制与血清Hcy水平及其他影响因素的相关性研究[J].现代检验医学杂志,2019,34(03):77-81.[doi:10.3969/j.issn.1671-7414.2019.03.019]
　LIU Qian-qian,LIU Xing-hui,WANG Hai-ming,et al.Effect of Glycemic Control on Serum Homocysteine Levelsin Type 2 Diabetes Mllitus and Its Association with Other Factors[J].Journal of Modern Laboratory Medicine,2019,34(03):77-81.[doi:10.3969/j.issn.1671-7414.2019.03.019]
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2型糖尿病患者血糖控制与血清Hcy水平及其他影响因素的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年03期
页码:
77-81
栏目:
论著
出版日期:
2019-06-20

文章信息/Info

Title:
Effect of Glycemic Control on Serum Homocysteine Levelsin Type 2 Diabetes Mllitus and Its Association with Other Factors
文章编号:
1671-7414(2019)03-077-05
作者:
刘倩倩; 刘兴晖; 王海明; 王 艳; 韩书光; 鲁作华
(上海市浦东新区公利医院检验科,上海 200135)
Author(s):
LIU Qian-qian; LIU Xing-hui; WANG Hai-ming; WANG Yan; HAN Shu-guang; LU Zuo-hua
(Department of Clinical Laboratory,Gongli Hospital of Pudong New Area in Shanghai,Shanghai 200135,China)
关键词:
2型糖尿病;  同型半胱氨酸;  糖化血红蛋白
分类号:
R587.1; R446.112
DOI:
10.3969/j.issn.1671-7414.2019.03.019
文献标志码:
A
摘要:
目的 探讨2型糖尿病(T2DM)患者血糖控制与血清同型半胱氨酸(Hcy)水平及其他影响因素的相关性。方法 选取2018年7～10月在上海市浦东新区公利医院内分泌门诊诊断为T2DM的成人患者370例为研究对象。检测患者糖化血红蛋白(HbA1c),Hcy,低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)等水平。根据HbA1c水平将370例T2DM患者分为HbA1c≤7%和HbA1c>7%两组,分析Hcy,LDL-C和HDL-C等水平差异。根据Hcy水平将370例T2DM患者分为高Hcy组(Hcy>15.4 μmol/L)和正常Hcy组(Hcy≤15.4 μmol/L),进行两组患者HbA1c,LDL-C和HDL-C等水平的单因素分析,采用Logistic回归分析评估高水平Hcy的危险因素。结果 HbA1c分组中,HbA1c较低组患者的Hcy,年龄和LDL-C均低于HbA1c较高组,差异均有统计学意义(t=-3.76,0.85,-2.02,均P<0.05)。Hcy分组中,高Hcy组患者的HbA1c,年龄均高于正常Hcy组,HDL-C低于正常Hcy组,男性患者多于女性患者,差异均有统计学意义(χ2=15.39,5.78,7.46,11.95,均P<0.05)。Logistic回归分析显示,性别、HbA1c,年龄和HDL-C这四个因素是影响T2DM患者Hcy水平升高的危险因素(P<0.05)。结论 控制血糖能够影响2型糖尿病患者血清Hcy水平,起到预防心血管疾病的重要作用。
Abstract:
Objective To investigate the effect of glucosecontrol on serum homocysteine(Hcy)levels in type 2 diabetes mellitus(T2DM)andits association with other factors.Methods A retrospective study was performed on 370 adult patients diagnosed with type 2 diabetes mellitus(T2DM)in the endocrine clinic of Gongli Hospital to Pudong New Area in Shanghai from July 2018 to October 2018.The hemoglobin A1c(HbA1c),Hcy low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)levels of in patients were tested.According to the level of HbA1c,370 patients with type II diabetes were divided into two groups:HbA1c ≤7% and HbA1c>7%.The differences in Hcy,LDL-C and HDL-C levels were analyzed.According to the level of Hcy,370 patients with T2DM were divided into two groups:high Hcy(Hcy>15.4 μmol/L)and normal Hcy(Hcy≤15.4 μmol/L.Univariate analysis ofHbA1c,LDL-C and HDL-C levels in these two groups was carried out,and Logistic multivariate regression analysis was used to determine the risk factors of high Hcy level.Results In HbA1c group,the Hcy,age and LDL-C with lower HbA1c were lower than those with higher HbA1c,and the difference was statistically significant(t=-3.76,0.85,-2.02,all P<0.05),respectively.In the Hcy group,the age and HbA1c with high Hcy group was higherthan that in the normal Hcy group,and the HDL-C was lower than that in the normal Hcy group,the male patients were more than the female patients,and the difference was statistically significant(χ2=15.39,5.78,7.46,11.95,all P<0.05),respectively.Multivariate regression analysis showed that age,sex and HbA1c and HDL-C were the risk factors for the increase of Hcy level in T2DM patients(P<0. 05).Conclusion Good glycem control can affect the level of serum Hcy and play an important role in preventingcardiovascular diseases in T2DM patients.

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备注/Memo

备注/Memo:
作者简介:刘倩倩(1981-),女,理学学位,主管技师,从事血液体液临床检验及血液细胞的临床及基础研究,E-mail:qianqianliu25@163.com。 收稿日期:2019-02-25 修回日期:2019-03-21
更新日期/Last Update: 2019-06-20