[1]朱 婷,吕艳关.妊娠期肝内胆汁淤积症患者血清肝胆酸、总胆汁酸水平及血浆凝血功能检测的临床诊断意义[J].现代检验医学杂志,2019,34(04):79-82.[doi:10.3969/j.issn.1671-7414.2019.04.019]
　ZHU Ting,L(¨overU)Yan-guan.Clinical Significance of Serum Hepatocholic Acid, Total Bile Acid Level and Plasma Coagulation Function Test in Patients with Intrahepatic Cholestasis During Pregnancy[J].Journal of Modern Laboratory Medicine,2019,34(04):79-82.[doi:10.3969/j.issn.1671-7414.2019.04.019]
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妊娠期肝内胆汁淤积症患者血清肝胆酸、总胆汁酸水平及血浆凝血功能检测的临床诊断意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
79-82
栏目:
论著
出版日期:
2019-08-20

文章信息/Info

Title:
Clinical Significance of Serum Hepatocholic Acid, Total Bile Acid Level and Plasma Coagulation Function Test in Patients with Intrahepatic Cholestasis During Pregnancy
文章编号:
1671-7414(2019)04-079-04
作者:
朱 婷; 吕艳关
(扬州大学附属淮安市妇幼保健院检验科,江苏淮安 223002)
Author(s):
ZHU Ting; L(¨overU)Yan-guan
(Department of Laboratory Clinical,Huai'an Women & Children Hospital,Affiliated to Yangzhou University,Jiangsu Huai'an223002,China)
关键词:
妊娠期肝内胆汁淤积症;  肝胆酸;  总胆汁酸;  凝血功能
分类号:
R714.255; R446.11
DOI:
10.3969/j.issn.1671-7414.2019.04.019
文献标志码:
A
摘要:
目的 探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)患者血清肝胆酸(courage acid,CG)、总胆汁酸(total bile acid,TBA)水平及血浆凝血功能检测的临床诊断意义。方法 随机选择31例妊娠期肝内胆汁淤积症患者(ICP组)及31例正常妊娠孕妇(对照组)作为研究对象,分别检测两组血清CG,TBA,丙氨酸氨基转移酶(alanine aminotransferase,ALT)、门冬氨酸氨基转移酶(aspartate aminotransferase,AST)以及血浆凝血酶原时间(prothrombin time,PT)、活化部分的凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)、纤维蛋白原(fibrinogen,FIB)和D-二聚体(D-Dimer,D-D),并对结果进行统计学分析。结果 ①ICP组CG水平(27.14±18.63 mg/L)和TBA水平(50.93±29.69 μmol/L)均高于对照组(1.14±0.30 mg/L,2.96±1.61 μmol/L),差异具有统计学意义(t=7.73,9.04,均P<0.01),与正常对照组相比,ICP组血清CG和TBA表达水平明显增高。②ICP组血清ALT,AST水平分别为109.01±84.47U/L和96.15±80.51 U/L,对照组血清ALT,AST水平分别为13.27±5.07 U/L和18.24±4.69 U/L,差异均具有统计学意义(t=6.29,5.39,均P<0.01)。③ICP组FIB,D-D水平分别为4.61±1.12 g/L和2.41±1.69 mg/L,对照组FIB,D-D水平分别为3.41±0.32 g/L和1.45±0.87 mg/L,差异均具有统计学意义(t=6.10,2.91,均P<0.01),但两组之间PT,APTT和TT水平比较差异无统计学意义(t=0.49,0.93,1.20,均P>0.05)。结论 ICP患者血清CG,TBA水平升高及凝血功能的改变,对ICP的早期诊断及监测具有重要的临床意义。
Abstract:
Objective To investigate the clinical significance of serum courage acid(CG),total bile acid(TBA)and plasma coagulation function in intrahepatic cholestasis during pregnancy.Methods 30 patients with intrahepatic cholestasis of pregnancy(ICP group)and 30 cases of normal pregnant women(control group)were randomly selected as the studysubjects.Indexes including CG,TBA,ALT,AST,PT,APTT,TT,FIB and D-D were detected,and the results were compared.Results ①The levels of CG(27.14±18.63 mg/L)and TBA(50.93±29.69 mol/L)in ICP group werehigher than those in the control group(1.14±0.30 mg/L,2.96±1.61 mol/L),and the difference were statistically significant(t=7.73,9.04,all P<0.01).Compared with the normal control group,the CG and TBA expression inICP group were significantly increased.②The serum ALT and AST levels of the ICP group were 109.01±84.47 U/L and 96.15±80.51 U/L,and the serum ALT and AST levels in control group were 13.27±5.07 U/L and 18.24±4.69 U/L,respectively.The differences were all statistically significant(t=6.29,5.39,all P<0.01).③The levels of FIB and D-D in ICP group were 4.6±1.12 g/Land 2.41±1.69 mg/L,respectively and the levels of FIB and D-D in control group were 3.4±0.32 g/L and 1.45±0.87 mg/L,respectively.The differences were all statistically significant(t=6.10,2.91,all P<0.01).However,there were no significant differences in PT,APTT,TT levels between the two groups(t=0.49,0.93,1.20,all P>0.05).Conclusion Elevated serum CG and TBA levels and changes of coagulation function in patients with intrahepatic cholestasis during pregnancy have important clinical significance for the early diagnosis and monitoring of ICP.

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备注/Memo

备注/Memo:
通讯作者:吕艳关(1981-),男,硕士,副主任技师,研究方向:临床免疫学诊断,E-mail:lvyanguan@163.com收稿日期:2019-04-03 修回日期:2019-04-13
更新日期/Last Update: 2019-07-30