[1]赵 娜a,康利宝b.红细胞分布宽度指标预测骨关节炎炎症进程的临床价值[J].现代检验医学杂志,2019,34(04):91-95.[doi:10.3969/j.issn.1671-7414.2019.04.022]
　ZHAO Naa,KANG Li-baob.Clinical Value of Red Blood Cell Distribution Width in Predicting Inflammatory Progression of Osteoarthritis[J].Journal of Modern Laboratory Medicine,2019,34(04):91-95.[doi:10.3969/j.issn.1671-7414.2019.04.022]
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红细胞分布宽度指标预测骨关节炎炎症进程的临床价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
91-95
栏目:
论著
出版日期:
2019-08-20

文章信息/Info

Title:
Clinical Value of Red Blood Cell Distribution Width in Predicting Inflammatory Progression of Osteoarthritis
文章编号:
1671-7414(2019)04-091-05
作者:
赵 娜a; 康利宝b
(陕西省榆林市第二医院a.检验科; b.输血科,陕西榆林 719000)
Author(s):
ZHAO Naa; KANG Li-baob
(a.Department of Clinical Laboratory; b.Department of Blood Transfusion,the Second Hospital of Yulin,Shaanxi Yulin 719000,China)
关键词:
骨关节炎;  红细胞分布宽度;  炎症;  标记物
分类号:
R684.3; R446.111
DOI:
10.3969/j.issn.1671-7414.2019.04.022
文献标志码:
A
摘要:
目的 探讨红细胞分布宽度(red blood cell distribution,RDW)指标是否可以预测骨关节炎(osteoarthritis,OA)炎症进程的临床价值。方法 将2015年1月～2017年12月入住陕西省榆林市第二医院的78例OA患者和78例健康对照组纳入研究。回顾性分析受试对象外周血中白细胞(white blood cell,WBC)、红细胞(red bloodcell,RBC)、血小板(platelet,PLT)、血红蛋白(hemoglobin,HGB)、红细胞分布宽度(red blood cell distribution,RDW),C-反应蛋白(C-reactive protein,CRP)和红细胞沉降率(erythrocyte sedimentation rate,ESR)。酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白细胞介素-6(interleukin-6,IL-6)水平。对OA组患者RDW与炎性标记物(CRP,ESR,TNF-α和IL-6)进行相关性分析。结果 OA组RDW水平明显高于健康对照组[(13.97±1.04)% vs(12.94±0.82)%,P<0.001]。此外,RDW诊断OA的ROC曲线下面积(AUC)为0.798(95%CI:0.725～0.871),敏感度为75.6%,特异度为78.2%。相关性分析显示OA 组患者RDW与CRP(r=0.476,P<0.001),ESR(r=0.347,P=0.002),TNF-α(r=0.428,P<0.001),IL-6(r=0.538,P<0.001)均呈显著正相关。结论 RDW水平在OA患者中是显著增高的,且与OA炎症是相关的,可以预测OA炎症进程的临床价值。
Abstract:
Objective To investigate whether red blood celldistribution width(RDW)can predict the inflammatory progression of osteoarthritis(OA)patients.Methods 78 cases of OA patients and 30 cases of healthy control were collected for the research objects in the SecondHospital of Yulin from January 2015 to December 2017.The white blood cell(WBC),red blood cell(RBC),platelet(PLT),hemoglobin(HGB),RDW,C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in peripheral blood of patients with OA were retrospectively analyzed.The levels of TNF-α and IL-6 weredetected by enzyme linked immunosorbent assay(ELISA).The correlations betweenthe levels of RDW and CRP,ESR,TNF-α and IL-6 in OA patients were analyzed.Results RDW level was significantly increased in OA patients compared with healthy controls(HC)[(13.97±1.04)% vs(12.94±0.82)%,P<0.001].In ROC analysis indicated that the area under the curve(AUC)was 0.798(95%CI:0.725～0.871)for the diagnosis of OA,with the sensitivity of75.6% and specificity of 78.2%.Correlation analysis showed that RDW was significant positively associated with CRP(r=0.476,P<0.001),ESR(r=0.347,P=0.002),TNF-α(r=0.428,P<0.001)and IL-6(r=0.538,P<0.001)in OA patients.Conclusion RDW was increased in patients with OA which was associated with inflammation in OA,and suggesting that RDWcan predict the inflammatory progression of osteoarthritis(OA)patients.

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备注/Memo

备注/Memo:
基金项目:陕西省自然科学基金项目(2013JM4016)。 作者简介:赵 娜(1983-),女,本科,主管检验师,研究方向:临床医学检验,E-mail:yuzhaon@163.com。 通讯作者:康利宝(1979-),男,本科,主管检验师,E-mail:1144814852@qq.com。收稿日期:2019-01-02 修回日期:2019-04-23
更新日期/Last Update: 2019-07-30