[1]易晓榕,张明忠,田卫华,等.湖北省恩施土家族苗族自治州不孕妇女不同年龄阶段血清抗苗勒管激素水平研究[J].现代检验医学杂志,2019,34(04):96-98.[doi:10.3969/j.issn.1671-7414.2019.04.023]
　YI Xiao-rong,ZHANG Ming-zhong,TIAN Wei-hua,et al.Changes of Anti-Mullerian Hormone Levels in Infertile Women of Different Ages in Enshi Minority Areas[J].Journal of Modern Laboratory Medicine,2019,34(04):96-98.[doi:10.3969/j.issn.1671-7414.2019.04.023]
点击复制

湖北省恩施土家族苗族自治州不孕妇女不同年龄阶段血清抗苗勒管激素水平研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
96-98
栏目:
论著
出版日期:
2019-08-20

文章信息/Info

Title:
Changes of Anti-Mullerian Hormone Levels in Infertile Women of Different Ages in Enshi Minority Areas
文章编号:
1671-7414(2019)04-096-03
作者:
易晓榕; 张明忠; 田卫华; 郑建波; 张凤凤; 谷琦琦
(恩施州中心医院生殖医学中心,湖北恩施 445000)
Author(s):
YI Xiao-rong; ZHANG Ming-zhong; TIAN Wei-hua; ZHENGJian-bo; ZHANG Feng-feng; GU Qi-qi
(Enshi State Central Hospital Reproductive Medicine Center,HubeiEnshi 445000,China)
关键词:
不孕;  抗苗勒管激素;  年龄;  卵巢
分类号:
R711.6; R392.11
DOI:
10.3969/j.issn.1671-7414.2019.04.023
文献标志码:
A
摘要:
目的 研究恩施地区不孕女性抗苗勒管激素的含量随年龄的变化。方法 2018年1月1日～11月9日,收集前来恩施州中心医院生殖中心检查的不孕女性血液样本,共619例,按照年龄分为5组,分别为≤25岁,26～30岁,31～35岁,36～40岁和≥41岁,检测其血清中的抗苗勒管激素含量,观察激素水平的变化情况,并检测抗苗勒管激素与年龄的相关性。结果 ≤25岁,26～30岁,31～35岁,36～40岁和≥41岁不孕妇女的抗苗勒管激素含量的中位数分别为4.41,4.19,3.44,1.92和0.52 ng/ml,平均水平分别为5.19±3.43,5.10±3.32,4.39±3.47,2.53±2.54和0.92±1.00 ng/ml,经H检验,H=164.31,P<0.01,差异有统计学意义,且抗苗勒管激素与年龄呈负相关(r=-0.4,P<0.01)。结论不孕女性体内抗苗勒管激素水平随着年龄的增长而逐渐降低,呈负相关,且有明显地域差异。
Abstract:
Objective To study the changes of anti-Mullerian hormone(AMH)levels in infertile women in women of different ages in Enshi Areas.Methods From January 1,2018 to November 9,2018,blood samples of infertile women who had been examined at the Reproductive Centerof Enshi Central Hospital were collected,a total of 619 cases,divided into 5groups according to age,respectively ≤25 years old,26～30 years old,31～35 years old,36～40 years old and ≥41 years old,the AMH content in the serum wasmeasured,the changes of hormone levels were observed,and the correlation between AMH and age was detected.Results The median AMH content of infertile fathers and daughters ≤25 years old,26～30 years old,31～35 years old,36～40 years old and ≥41 years old were 4.41,4.19,3.44,1.92 and 0.52 ng/ml,respectively.The average levels were 5.19±3.43,5.10±3.32,4.39±3.47,2.53±2.54 and 0.92±1.00 ng/ml,respectively.By H test,H=163.31,P<0.01,statistically significant,and AMH was negatively correlated with age(r=-0.4,P<0.01).Conclusion AMHlevels in infertile women gradually decrease with age,showing a negative correlation and significant regional differences.

参考文献/References:

[1] 张杰,尉春艳,陈庆,等.育龄期与围绝经期女性抗缪勒氏管激素及常规性激素水平的比较[J].中国临床研究,2017,30(12):1600-1603. ZHANG Jie,WEI Chunyan,CHEN Qing,et al.Changes of anti-Mullerianhormone and routine sex hormone levels in women of reprouductive period and peri-menopausal period[J].Chinese Journal of Clinical Research,2017,30(12):1600-1603. [2] LA MARCA A,MINASI M G,SIGHINOLFI G,et al.Female age,serum antimüllerian hormone level, and number of oocytes affect the rate and number of euploidblastocysts in in vitro fertilization/intracytoplasmic sperm injection cycles[J].Fertility and Sterility,2017,108(5):777-783. [3] TSAKOS E,TOLIKAS A,DANIILIDIS A,et al.Predictive value of anti-müllerian hormone,follicle-stimulating hormone and antral follicle count on the outcome of ovarian stimulation in women following GnRH-antagonist protocol for IVF/ET[J].Archives of Gynecology & Obstetrics,2014,290(6):1249-1253. [4] LA MARCA A,MALMUSI S,GIULINI S,et al.Anti-Mu¨llerian hormone plasmalevels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation[J].Hum Reprod,2004,19(12):2738-2741. [5] 黄佳语,高颖.AMH与卵巢储备功能及体外胚胎发育潜能的关系[J].生殖医学杂志,2017,26(1):82-86. HUANG Jiayu,GAO Ying.AMH and correlation with oocyte quality and embryonic developmental potential[J].Journal of Reproductive Medicine,2017,26(1):82-86. [6] 任妞,刘彦.生育期女性血清抗苗勒管激素水平的研究[J].中国妇产科临床杂志,2011,12(4):281-283. REN Niu,LIU Yan.Study of serum anti-Mullerian hormone levels in reproductive age women[J].Chinese Journal of Clinical Obstetrics and Gynecology,2011,12(4):281-283. [7] 高丽虹,蔡文伟,朱琴,等.抗苗勒管激素与年龄的关系及其预测卵巢衰老的临床研究[J].中华妇产科杂志,2015,50(5):352-355. GAO Lihong,CAI Wenwei,ZHU Qin,et al.Clinical study of anti-Mullerian hormone in prediction of ovarian aging[J].Chinese Journal of Obstetricsand Gynecology,2015,50(5):352-355. [8] 陈晓,季银芬,徐键.抗苗勒氏管激素(AMH)与多囊卵巢综合征(PCOS)卵泡发育异常的关系[J].生殖与避孕,2014,34(5):383-387,400. CHEN Xiao,JI Yinfen,XU Jian.Relationship of anti-Mullerian hormone(AMH)and polycystic ovary syndrome(PCOS)follicular dysplasia[J].Reproduction and Contraception,2014,34(5):383-387,400. [9] GOMEZ R,SCHORSCH M,HAHN T,et al.The influence of AMH on IVF success[J].Archives of Gynecology & Obstetrics,2016,293(3):667-673. [10] 徐慧玉,冯瑛,曾琳,等.育龄女性月经周期内及周期间血清抗苗勒管激素水平的变化研究[J].实用妇产科杂志,2017,33(5):358-362. XU Huiyu,FENG Ying,ZENG Lin,et al.Changes of serum anti-Mullerian hormone(AMH)levels in reproductiveaged women's intra and inter-menstrual cycle[J].Journal of Practical Obstetrics and Gynecology,2017,33(5):42-46. [11] FADDY M J,GOSDEN R G,GOUGEON A,et al.Accelerated disappearance of ovarian follicles in mid-life:implications of forecasting menopause[J].HumanReproduction,1992,7(10):1342-1346. [12] 田艳,赖冬,龙敏,等.厦门地区2 200例女性不孕患者AMH水平分析[J].中国优生与遗传杂志,2016,24(9):103-104. TIAN Yan,LAI Dong,LONG Min,et al.AMH level analysis of the changes ofanti-Mullerian hormone about 2 200 women with infertility in Xiamen[J].Chinese Journal of Birth Health and Genetics,2016(9):103-104.

备注/Memo

备注/Memo:
作者简介:易晓榕(1993-),女,硕士研究生,技师,专业:生殖医学,E-mail:1909948492@qq.com。收稿日期:2019-01-12 修回日期:2019-04-20
更新日期/Last Update: 2019-07-30