[1]马利军,屈晓威,邢延芳,等.血清Lp-PLA2,IMA和LDL-C水平检测与TCD联合检查在缺血性脑血管病早期诊断中的价值[J].现代检验医学杂志,2019,34(04):103-107.[doi:10.3969/j.issn.1671-7414.2019.04.025]
　MA Li-jun,QU Xiao-wei,XING Yan-fang,et al.Value of Detection of Serum Lp-PLA2,IMA and LDL-C Level and Combined TCD in Early Diagnosis of Ischemic Cerebrovascular Disease[J].Journal of Modern Laboratory Medicine,2019,34(04):103-107.[doi:10.3969/j.issn.1671-7414.2019.04.025]
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血清Lp-PLA2,IMA和LDL-C水平检测与TCD联合检查在缺血性脑血管病早期诊断中的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
103-107
栏目:
论著
出版日期:
2019-08-20

文章信息/Info

Title:
Value of Detection of Serum Lp-PLA2,IMA and LDL-C Level and Combined TCD in Early Diagnosis of Ischemic Cerebrovascular Disease
文章编号:
1671-7414(2019)04-103-05
作者:
马利军; 屈晓威; 邢延芳; 鲁雪婷; 王丽萍
(延安大学附属医院心脑血管病区检验科,陕西延安 716000)
Author(s):
MA Li-jun; QU Xiao-wei; XING Yan-fang; LU Xue-ting; WANG Li-ping
(Department of Clinical Laboratory,Branch of Cardiovascular andCerebrovascular Diseases,Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China)
关键词:
脂蛋白相关磷脂酶A2(LP-PLA2);  缺血修饰蛋白(IMA);  经颅多普勒超声(TCD);  缺血性脑血管病
分类号:
R743; 446.112
DOI:
10.3969/j.issn.1671-7414.2019.04.025
文献标志码:
A
摘要:
目的 研究脂蛋白相关磷脂酶A2(Lp-PLA2)、缺血修饰蛋白(IMA)、低密度脂蛋白胆固醇(LDL-C)及经颅多普勒超声(TCD)联合检测对缺血性脑血管病早期诊断的价值。方法 采用研究-对照的研究方法,选取2018年11月～2019年3月某院收治的98例经影像学确诊为缺血性脑血管病患者作为研究组,选取同期进行常规体检的100例健康人员作为对照组,两组均进行血清中Lp-PLA2,IMA,LDL-C及TCD检测,对比分析检测结果。结果 研究组Lp-PLA2,IMA,LDL-C及TCD检测水平均高于对照组,Lp-PLA2,IMA及TCD与对照组相比,差异具有统计学意义(t=12.984,12.820,25.645,均P<0.05); 而LDL-C与对照组相比,差异无统计学意义(t=1.720,P>0.05)。对各组检测指标做ROC曲线分析:单项IMA和Lp-PLA2曲线AUC均达到0.9以上其试验准确性很高,TCD 0.7～0.9之间其试验的准确性高,LDL-C等于0.5其试验无诊断价值[10]。联合结果为IMA+LDL-C+Lp-PLA2+TCD(0.963),IMA+Lp-PLA2+TCD(0.964)三项指标联合检测诊断时其诊断价值达到最大,它们之间相比其诊断价值差异均无统计学意义(P<0.05)。结论 缺血性脑血管病患者血清中Lp-PLA2,IMA及TCD的水平显著升高,早期对高危人群进行血清Lp-PLA2,IMA,LDL-C及TCD检测可以预测缺血性脑血管病的发生,对早期诊断和干预缺血性脑血管病有较高的应用价值。
Abstract:
Objective To study the value of detection of serum lipoprotein-associated phospholipase A2(Lp-PLA2),ischemia-modifying protein(IMA)and low-density lipoprotein cholesterol(LDL-C)levels and combinedTCD in early diagnosis of ischemic cerebrovascular diseases.Methods A study-control study was conducted to select 99 patients with ischemic cerebrovascular disease who were diagnosed by imaging in a hospital from November 20 to March 2019.100 healthy patients who underwent routine physical examination at the same time were selected.As a control group,the two groups were tested for serum Lp-PLA2,IMA,LDL-C and TCD,and the results were compared and analyzed.Results The levels of Lp-PLA2,IMA,LDL-C and TCD in the study group were higher than those in the control group.The difference between Lp-PLA2,IMA and TCD was statistically significant(t=12.984,12.820,25.645,all P<0.05).Comparing LDL-C with the control group,the difference was not statistically significant(t=1.720,P>0.05).The ROC curve analysis was carried out for each group of test indicators:the AUC of each single IMA and Lp-PLA2 curve reached 0.9or higher,and the test accuracy was very high.The accuracy of the test was high between TCD 0.7～0.9,and the LDL-C was equal to 0.5[10].The combined results were the highest diagnostic value of IMA+LDL-C+Lp-PLA2+TCD(0.963)and IMA+Lp-PLA2+TCD(0.964).The diagnostic value was the highest,and no statistical significance(P<0.05).Conclusion The levels of serum Lp-PLA2,IMA and TCD are significantly elevated in patients with ischemic cerebrovascular disease.Early detection of serum Lp-PLA2,IMA,LDL-Cand TCD in high-risk populations can predict ischemic cerebrovascular disease.Occurrence,has a high application value for early diagnosis and intervention ofischemic cerebrovascular disease.

参考文献/References:

[1] 朱宏杰.经颅多普勒超声在缺血性脑血管疾病早期诊断中的价值分析[J].医学理论与实践,2018,31(21):3262-3263. ZHU Hongjie.The value of transcranial doppler ultrasound in the early diagnosis of ischemic cerebrovascular disease[J].Journal Medical Theory and Practice,2018,31(21):3262-3263. [2] ZHONG Shanshan,LI Luxiao,SHEN Xia,et al.An update on lipid oxidationand inflammation in cardiovascular diseases[EB/OL].Free Radical Biology and Medicine,DOI:10.1016/j.freeradbiomed 2019.03.0 36. [3] 贺治民,李艳华.脂蛋白相关磷脂酶A2在冠心病及冠状动脉病变诊断中的作用探讨[J].山西医药杂志,2019,48(3):366-368. HE Zhimin,LI Yanhua.The role of lipoprotein-associated phospholipase A2 in the diagnosis of coronary heart disease and coronary artery disease[J].Shanxi Medical Journal,2019,48(3):366-368. [4] KONG Qi,MA Xin,WANG Chen,et al.Influence of age ranges on relationship of complex aortic plaque with cervicocephalic atherosclerosis in ischemic stroke[J].Journal of Stroke and Cerebrovascular Diseases,2019,28(6),1586-1596. [5] 陈庆宇,王宝,侯秀伟,等.缺血修饰白蛋白在心血管病中的研究进展[J].国际心血管病杂志,2018,45(3):143-145. CHEN Qingyu,WANG Bao,HOU Xiuwei,et al.Research progress of ischemic modified albumin in cardiovascular disease[J].International Journal of Cardiovascular Diseases,2018,45(3):143-145. [6] 张林英.经颅多普勒超声联合颈动脉超声对缺血性脑血管病的诊断价值[J].中国初级卫生保健,2018,32(2):86-88. ZHANG Linying.Diagnostic value of transcranial doppler ultrasonography combined with carotid artery ultrasound in ischemic cerebrovascular disease[J].Chinese Primary Health Care,2018,32(2):86-88. [7] 王娜梅,赵玉红,解旭东,等.缺血性脑血管病的治疗现状及进展研究[J].医学综述,2017,23(19):3822-3826,3831. WANG Namei,ZHAO Yuhong,XIE Xudong,et al.Current situation and advance of ischemic cerebrovascular disease[J].Medical Recapitulate,2017,23(19):3822-3826,3831. [8] 范小斌,李广华,龚彩平,等.ROC曲线评价凝血功能指标对妊高征的诊断价值[J].血栓与止血学,2018,24(6):921-924. FAN Xiaobin,LI Guanghua,GONG Caiping,et al.The diagnostic valueof ROC curve in the diagnosis of pregnancy induced hypertension[J].Chinese Journal of Thrombosis and Hemostasis,2018,24(6):921-924. [9] 张楠.经颅多普勒与颈动脉超声检测缺血性脑血管疾病的临床价值[J].影像研究与医学应用,2019,3(4):189-190. ZHANG Nan.Clinical value of transcranial doppler and carotid ultrasound in detecting ischemic cerebrovascular disease[J].Image Research and Medical Application,2019,3(4):189-190. [10] 左瑞菊,时婧,韩晓霞,等.早期监测并干预脂蛋白相关磷脂酶A2在高危缺血性脑卒中人群中的意义[J].脑与神经疾病杂志,2018,26(6):351-353. ZUO Ruiju,SHI Jing,HAN Xiaoxia,et al.Significance of early detection and intervention of lipoprotein associated phospholipase A2 in patients with high-risk ischemic stroke[J].Journal of Brain and Nervous Diseases,2018,26(6):351-353. [11] HU Yun,LI Tingting,ZHOU Wei,et al.Lipoprotein-associated phospholipase A2 is a risk factor for diabetic kidney disease[J].Diabetes Research andClinical Practice,2019,150:194-201. [12] USHU A U,KUCUK A,BALTA S,et al.The relation between ischemia modified albumin levels and carotid intima media thickness in patients with rheumatoidarthritis[J].International Journal of Rheumatic Diseases,2019,22:32-37. [13] 陆梦丽,吕礼应.脂蛋白相关磷脂酶A2检测方法及其临床应用进展[J].国际检验医学杂志,2018,39(18):2313-2316,2334. LU Mengli,L(¨overU)Liying.The detection method of lipoprotein-relatedphospholipase A2 and its clinical application progress[J].International Journal of Laboratory Medicine,2018,39(18):2313-2316,2334. [14] 陈东芳.血清胆红素与低密度脂蛋白胆固醇水平及缺血性脑血管病的关系[J].长治医学院学报,2015,29(6):436-438. CHEN Dongfang.The relationship between serum bilirubin and low density lipoprotein cholesterol and ischemic cerebrovascular disease[J].Journal of Changzhi Medical College,2015,29(6):436-438. [15] 魏向坤.TCD联合血清Hcy水平检测在冠心病患者诊断中的应用价值[J].河南医学研究,2018,27(19):3606-3607. WEI Xiangkun.The application value of TCDcombined with serum Hcy level inthe diagnosis of patients with coronary heart disease[J].Henan Medical Research,2018,27(19):3606-3607. [16] 岑坚兴,何苑英.TCD对脑梗死患者预后的评估价值观察[J].数理医药学杂志,2018,31(11):1593-1595. CEN Jianxing,HE Yuanying.The evaluation value of TCD for the prognosis of patients with cerebral infarction[J].Journal of Mathematical Medicine,2018,31(11):1593-1595. [17] 马同敏,赵志强.血清CA125,STIP1和IGF-Ⅰ联合检测对卵巢癌的早期诊断价值研究[J].现代检验医学杂志,2018,33(6):50-54,58. MA Tongming, ZHAO Zhiqiang.Clinical value of combined detection of serum CA125,STIP1 and IGF-I levels in ovarian cancer[J].Journal of Modern Laboratory Medicine,2018,33(6):50-54,58.

备注/Memo

备注/Memo:
作者简介:马利军(1988-),男,本科,主管检验师,临床检验诊断学,E-mail:649763467@qq.com。 通讯作者:王丽萍(1961-),女,本科,主管检验师,临床检验诊断学,E-mail:275601002@qq.com。收稿日期:2019-04-06 修回日期:2019-04-27
更新日期/Last Update: 2019-07-30