[1]杜 静,李嘉丽,晏耀明,等.多囊卵巢综合征患者血清AMH,LH和FSH水平检测及临床应用研究[J].现代检验医学杂志,2019,34(05):68-71.[doi:10.3969/j.issn.1671-7414.2019.05.017]
　DU Jing,LI Jia-li,YAN Yao-ming,et al.Detection and Clinical Application of Serum AMH,FSH and LH in Patients with Polycystic Ovarian Syndrome[J].Journal of Modern Laboratory Medicine,2019,34(05):68-71.[doi:10.3969/j.issn.1671-7414.2019.05.017]
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多囊卵巢综合征患者血清AMH,LH和FSH水平检测及临床应用研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年05期
页码:
68-71
栏目:
论著
出版日期:
2019-10-29

文章信息/Info

Title:
Detection and Clinical Application of Serum AMH,FSH and LH in Patients with Polycystic Ovarian Syndrome
文章编号:
1671-7414(2019)05-068-04
作者:
杜 静1; 李嘉丽1; 晏耀明1; 唐 晖1; 吴玉红1; 杨 超2
(1.北京大学深圳医院检验科,深圳 518036; 2.深圳市人民医院外科,广东深圳 518020)
Author(s):
DU Jing1; LI Jia-li1; YAN Yao-ming1; TANG Hui1; WU Yu-hong1; YANG Chao2 (1.Department of Laboratory Medicine; Peking University ShenzhenHospital; Shenzhen 518036;  China; 2.Department of Surgery; Sh
(1.Department of Laboratory Medicine,Peking University ShenzhenHospital,Shenzhen 518036, China; 2.Department of Surgery,Shenzhen People's Hospital,Shenzhen 518020,China)
关键词:
抗缪勒氏管激素(AMH);  多囊卵巢综合征(PCOS);  卵泡刺激素(FSH);  黄体生成素(LH);  受试者工作特征曲线(ROC)
分类号:
R711.75; R392.11
DOI:
10.3969/j.issn.1671-7414.2019.05.017
文献标志码:
A
摘要:
目的 分析抗缪勒氏管激素(AMH)、黄体生成素(LH)和卵泡刺激素(FSH)在常见妇科疾病患者血清中的表达水平,探讨AMH对多囊卵巢综合征(PCOS)的诊断价值。方法 采用化学发光法检测1 089例常见妇科疾病患者血清AMH,LH和FSH,比较不同年龄组和不同疾病组中的血清AMH水平差异,分析PCOS患者中AMH与LH/FSH的相关性,绘制ROC曲线,计算出诊断PCOS的最佳截断值。结果 ①AMH水平随着年龄的增加而下降; 各个年龄组PCOS患者的血清AMH水平均明显高于同年龄组的健康女性(P<0.05),其他妇科疾病患者的血清AMH水平与同年龄组的健康女性相比,差异无统计学意义(P>0.05); ②PCOS患者和健康女性的血清AMH水平与LH/FSH呈中度正相关(r=0.304,0.464,P<0.00); ③AMH=6.895ng/ml为PCOS诊断界值时,敏感度为82.8%,特异度为79.6%,曲线下面积为0.886,具有最高诊断效能。在LH/FSH=0.960时,敏感度为75.5%,特异度为80.2%,ROC曲线下面积为0.832,具有最高诊断效能。结论 血清AMH水平升高是PCOS患者生殖内分泌代谢紊乱的重要特征,采用ROC曲线分析确立AMH的cutoff值为6.895 ng/ml时,对PCOS诊断具有较大临床价值。
Abstract:
Objective To determine the diagnosis value of anti-Mullerian hormone(AMH)for polycystic ovarian syndrome(PCOS)by assessing serum AMH,follicle stimulating hormone(FSH)and luteinizing hormone(LH)levels in patients with different common gynecological diseases.MethodsChemiluminescence Microparticle Immunoassay(CMIA)was used to testthe serum level of AMH,follicle stimulating hormone(FSH)and luteinizing hormone(LH)in 1 089 patients with common gynecological diseases.The differencesbetween serum AMH levels of patients in different age groups or with different diseases were analyzed,and the relevance between the level of AMH and LH/FSH ratio in PCOS was investigated.ROC curve was employed to find the cut off value ofAMH and LH/FSH ratio.Results ①The serum AMH levels were found to be decreased with the increase of age.In the same age groups,the serum AMH level in PCOS was significantly higher than in healthy women(P<0.05).The difference in the serum AMH level between other gynecological diseases patients and healthy women of the same age group was no statistically significant(P>0.05).②Serum AMH level was moderate positively correlated with LH/FSHratio in healthy persons and PCOS(r=0.464,0.304).③The PCOS diagnosiswas most efficient when the cut off value of AMH was 6.895 ng/ml,it's sensitivity of 82.8%,specificity of 79.6% and area under ROC curve was 0.886 respectively.With 75% sensitivity and 80.2% specificity,it was most efficient forPCOS diagnosis when the cut off value of LH/FSH ratio was set at 0.960,with area under the ROC curve of 0.886.Conclusion The elevatedserum level of AMH is an important character of endocrine and metabolic abnormalities in PCOS.To ensure the better diagnostic value,the level of AMH shouldbe set at 6.895 ng/ml to get higher specificity as well as sensitivity.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:深圳市科创委项目(JCYJ20160422144926)。 作者简介:杜 静(1971-),女,博士,主任技师,从事临床免疫检验工作,主要研究方向:自身免疫性疾病研究,E-mail:dujing83@hotmail.com。 通讯作者:杨 超(1970-)男,博士,主任医师,从事心血管方向研究,E-mail:tschaoyang@gmail.com
更新日期/Last Update: 2019-10-20