[1]马 欢a,田小飞b,李红霞.复发性卵巢癌患者血清NDRG4水平表达与临床特征及预后的相关性研究[J].现代检验医学杂志,2019,34(05):81-83.[doi:10.3969/j.issn.1671-7414.2019.05.020]
 MA Huana,TIAN Xiao-feib,LI Hong-xia.Correlation between Serum NDRG4 Expression and Clinical Features and Prognosis in Patients with Recurrent Ovarian Cancer[J].Journal of Modern Laboratory Medicine,2019,34(05):81-83.[doi:10.3969/j.issn.1671-7414.2019.05.020]
点击复制

复发性卵巢癌患者血清NDRG4水平表达与临床特征及预后的相关性研究()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年05期
页码:
81-83
栏目:
论著
出版日期:
2019-10-29

文章信息/Info

Title:
Correlation between Serum NDRG4 Expression and Clinical Features and Prognosis in Patients with Recurrent Ovarian Cancer
文章编号:
1671-7414(2019)05-081-03
作者:
马 欢1a田小飞1b李红霞2
(1.榆林市第一医院绥德院区a.妇产科; b.小儿一科,陕西榆林 718000; 2.延安大学附属医院妇科,陕西延安 716000)
Author(s):
MA Huan1aTIAN Xiao-fei1bLI Hong-xia2
(1a.Department of Obstetrics and Gynecolog; 1b.Department of Pediatric, Suide Hospital of Yulin First Hospital,Shaanxi Yulin 718000,China; 2.Department of Gynaecology,Affiliated Hospital of Yan'an University,Shaanxi Yan'an 716000,China)
关键词:
复发性卵巢癌 血清 抑癌基因N-myc下游调节因子4(NDRG4) 预后
分类号:
R737.31; R730.43
DOI:
10.3969/j.issn.1671-7414.2019.05.020
文献标志码:
A
摘要:
目的 探讨复发性卵巢癌(recurrent ovarian cancer,ROC)患者血清抑癌基因N-myc下游调节因子4(N-myc downscream regulated gene 4,NDRG4)蛋白质的表达水平及其对预后的影响。方法 通过电化学发光法检测课题组2010年1月~2014年12月所收集到的147例ROC患者血清NDRG4蛋白质的表达水平,并分析其蛋白质水平与ROC患者临床特征之间的关联。结果 NDRG4蛋白在ROC患者不同临床分期患者之间的表达差异有统计学意义(F=20.311,P<0.001),高NDRG4蛋白水平和临床分期较晚呈正相关(γ=0.326,P<0.001),且NDRG4蛋白质水平与ROC患者的吸烟(χ2=10.600,P=0.001)、饮酒(χ2=5.033,P=0.028)、肿瘤临床分期(χ2=9.918,P=0.003)、T分期(χ2=33.344,P<0.001)、N分期(χ2=12.392,P<0.001)和M分期(χ2=6.714,P=0.013)相关。结论 NDRG4在ROC中发挥抑癌作用,血清NDRG4水平较高的ROC患者预后较好。
Abstract:
Objective To explore the expression level and effect of NDRG4 protein in serum of patients with recurrent ovarian cancer(ROC).Methods Detected the expression level of NDRG4 proteinin the serum of recurrent ROC patients using electrochemiluminescence,and analysed the correlation of the NDRG4 protein level and clinical characteristics.Results NDRG4 protein was differently expressed in different clinical stage of recurrent ovarian cancer(ROC)patients(F=20.311,P<0.001),and the high level of NDRG4 protein was correlated with the late clinical stage(γ=0.326,P<0.001)of the patients.NDRG4 protein level was correlated with smoking(χ2=10.600,P=0.001),drinking(χ2=5.033,P=0.028),clinical stage(χ2=9.918,P=0.003),T stage(χ2=33.344,P<0.001),N stage(χ2=12.392,P<0.001),M stage(χ2=6.714,P=0.013).Conclusion NDRG4 acted as a tumor suppressor inROC patients with higher level of serum NDRG4 protein would had a better prognosis.

参考文献/References:

[1] 郑荣寿,张思维,吴良有,等.中国肿瘤登记地区2008年恶性肿瘤发病和死亡分析[J].中国肿瘤,2012,21(1):1-12. ZHENG Rongshou,ZHANG Siwei,WU Liangyou,et al.Report of incidenceand mortality from China cancer registries in 2008[J].China Cancer,2012,21(1):1-12. [2] 曾红梅,郑荣寿,张思维,等.1989~2008年中国恶性肿瘤死亡趋势分析[J].中华肿瘤杂志,2012,34(7):525-531. ZENG Hongmei,ZHENG Rongshou,ZHANG Siwei,et al.Trend analysis of cancer mortality in China between 1989 and2008[J].Chinese Journal of Oncology,2012,34(7):525-531. [3] CHEN Wenqing.Cancer statistics:Updated cancer burden in China[J].Chin J Cancer Res,2015,27(1):1. [4] SIEGEL R L,MILLER K D,JEMAL A.Cancer statistics,2019[J].CA CancerJ Clin,2019,69(1):7-34. [5] 张善弟,荆成宝,禹梅.血清CEA,CA125和HE4联合检测对卵巢癌的诊断价值 [J].现代检验医学杂志,2018,33(6):122-124,131. ZHANG Shandi,JING Chengbao,YU Mei.Clinial value of combined detection of serum CEA,CA125,and HE4 in the diagnosis of ovarian cancer[J].Journal of Modern Laboratory Medicine,2018,33(6):122-124,131. [6] 马同敏,赵志强.血清CA125,STPI和IGF-1联合检测对卵巢癌的早期诊断价值研究[J].现代检验医学杂志,2018,33(6):50-54,58. MA Tongmin,ZHAO Zhiqiang.Clincal value of combined detection of serum CA125,STIP1 and IGF-I level in early diagnosis of ovarian cancer[J].Journal of Modern Laboratory Medicine,218,33(6):50-54,58. [7] BRAY F,FERLAY J,SOERJOMATARAM I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424. [8] 徐金良,杜丹丹,翟志敏,等.卵巢良恶性肿瘤患者血液NIR,IMR,RDW,PLR四项参数的变化及其临床意义[J].现代检验医学杂志,2018,33(2):16-18,22. XU Jinliang,DU Dandan,ZHAI Zhimin,et al.Changes and clinical significance of four parameters of NLR,LMR,RDW and PLR in patients with benign and malignant ovarian tumors[J].Journal of Modern Laboratory Medicine,2018,33(2):16-18,22. [9] 曹雪娇,董丽娜,谭文华,等.NDRG4在卵巢癌中的表达[J].哈尔滨医科大学学报,2017,51(5):434-437. CAO Xuejiao,DONG Lina,TAN Wenhua,et al.Expression of NDRG4 in ovarian cancer[J].Journal of Harbin Medical University,2017,51(5):434-437. [10] CHEN Wanqing,SUN Kexin,ZHENG Rongshou,et al.Cancer incidenceand mortality in China,2014[J].Chin J Cancer Res,2018,30(1):1-12. [11] CHEN Wanqing, ZHENG Rongshou, ZHANG Siwei,et al.Cancer incidence andmortality in China in 2013:an analysis based on urbanization level[J].ChinJ Cancer Res,2017,29(1):1-10. [12] DESANTIS C E,LIN C C,MARIOTTO A B,et al.Cancer treatment and survivorship statistics,2014[J].CA Cancer J Clin,2014,64(4):252-271. [13] FERLAY J,COLOMBET M,SOERJOMATARAM I,et al.Cancer incidence and mortality patterns in Europe:Estimates for 40 countries and 25 major cancers in 2018[J].Eur J Cancer,2018,103:358-387. [14] KASSEBAUM N J,BERTOZZI-VILLA A,COGGESHALL M S,et al.Global,regional,and national levels and causes of maternal mortality during 1990-2013:A systematic analysis for the global burden of disease study 2013[J].Lancet,2014,384(9947):980-1004. [15] SMITH R A,MANASSARAM-BAPTISTE D,BR-OOKS D,et al.Cancer screening in the united states,2015:A review of current American Cancer Society guidelines and current issues in cancer screening[J].CA Cancer J Clin,2015,65(1):30-54. [16] ZENG Hongmei,ZHENG Rongshou,GUO Yuming,et al.Cancer survival in China,2003~2005:a population-based study[J].Int J Cancer,2015,136(8):1921-1930. [17] 赵慧霞,李秋文,董伟伟,等.NDRG4基因甲基化检测在结直肠癌早期诊断中的应用研究[J].中国医药导报,2012,9(13):29-31. ZHAO Huixia,LI Qiuwen,DONG Weiwei,et al.Study of early diagnosis of colorectal cancer by analysis of NDRG4 gene methylation[J].China Medical Herald,2012,9(13):29-31. [18] 严志进,刘云龙,邹秉杰,等.粪便中大肠癌特异性NDRG4基因甲基化水平的超高灵敏定量检测法[J].医学研究生学报,2016,29(10):1031-1035. YAN Zhijin,LIU Yunlong,ZOU Bingjie,et al.Ultra-sensitive quantification of the colorectal cancer-specific NDRG4 gene methylation levels in stool[J].J Med Postgra,2016,29(10):1031-1035. [19] 商远方,朱耀明,朱晨宇.NDRG4基因的表达调控及生物学效应研究进展[J].生命科学,2012,24(7):691-695. SHANG Yuanfang,ZHU Yiaoming,ZHU Chenyu.Research advancement of expression regulation and biological effects of NDRG4 gene[J].Chinese Bulletin of Life Sciences,2012,24(7):691-695. [20] 罗会芳,张勇.NDRG4在宫颈癌细胞中的表达及其对增殖的影响[J].实用医学杂志,2016,32(22):3673-3676.

相似文献/References:

[1]蔡加炉,王 成,汪俊军.循环微小核糖核酸与2型糖尿病的关系[J].现代检验医学杂志,2015,30(03):5.[doi:10.3969/j.issn.1671-7414.2015.03.002]
 CAI Jia-lu,WANG Cheng,WANG Jun-jun.Relationship between Circulating miRNA and Type 2 Diabetes[J].Journal of Modern Laboratory Medicine,2015,30(05):5.[doi:10.3969/j.issn.1671-7414.2015.03.002]
[2]唐海霞,王 成,路美玲,等.肾透明细胞癌患者血清miR-193a-3p水平增加及早期诊断价值[J].现代检验医学杂志,2015,30(03):43.[doi:10.3969/j.issn.1671-7414.2015.03.012]
 TANG Hai-xia,WANG Cheng,LU Mei-ling,et al.Elevated Serum miR-193a-3p Level in Renal Clear Cell Carcinoma and Its Early Clinical Value[J].Journal of Modern Laboratory Medicine,2015,30(05):43.[doi:10.3969/j.issn.1671-7414.2015.03.012]
[3]黄金文,李如凯,高 婧,等.孕妇血清半胱氨酸蛋白酶抑制剂C参考范围的研究[J].现代检验医学杂志,2016,31(04):133.[doi:10.3969/j.issn.1671-7414.2016.04.039]
 HUANG Jin-wen,LI Ru-kai,GAO Jing,et al.Study on the Reference Interval of Serum Cystatin C of Pregnant Women[J].Journal of Modern Laboratory Medicine,2016,31(05):133.[doi:10.3969/j.issn.1671-7414.2016.04.039]
[4]万淑君,王 成,王 静,等.2型糖尿病微血管并发症患者血清miR-16,miR-126和miR-221水平检测及临床意义[J].现代检验医学杂志,2016,31(05):9.[doi:10.3969/j.issn.1671-7414.2016.05.003]
 WAN Shu-jun,WANG Cheng,WANG Jing,et al.Study on Serum Levels of miR-16,miR-126 and miR-221 and Their Clinical Significance in Type 2 Diabetes Patients with or Without Microvascular Complications[J].Journal of Modern Laboratory Medicine,2016,31(05):9.[doi:10.3969/j.issn.1671-7414.2016.05.003]
[5]朱卫华,刘继斌,林兰.胃癌相关甲基化分型与幽门螺杆菌感染的探讨[J].现代检验医学杂志,2016,31(06):55.[doi:10.3969/j.issn.1671-7414.2016.06.015]
 ZHU Wei-hua,LIU Ji-bin,LIN Lan.Relationship between the CpG Island Methylator Phenotype and Helicobacter Pylori Infection Associated with Gastric Cancer[J].Journal of Modern Laboratory Medicine,2016,31(05):55.[doi:10.3969/j.issn.1671-7414.2016.06.015]
[6]李兵,傅尧,符义富,等.IL-17F在口腔鳞状细胞癌患者血清中的表达及意义[J].现代检验医学杂志,2016,31(06):77.[doi:10.3969/j.issn.1671-7414.2016.06.021]
 LI Bing,FU Yao,FU Yi-fu,et al.Expression of Interleukin 17F in Serum of Oral Squamous Cell Carcinoma Patients and Its Clinic Significance[J].Journal of Modern Laboratory Medicine,2016,31(05):77.[doi:10.3969/j.issn.1671-7414.2016.06.021]
[7]卜晓敏,宋佳希,樊春荔,等.颅脑损伤患者血清αⅡ血影蛋白裂解产物(SBDPs)水平检测的临床意义[J].现代检验医学杂志,2017,32(01):9.[doi:10.3969/j.issn.1671-7414.2017.01.003]
 BU Xiao-min,SONG Jia-xi,FAN Chun-li,et al.Study on Serum Levels of SBDPs and Their Clinical Significance in Patients with Traumatic Brain Injury[J].Journal of Modern Laboratory Medicine,2017,32(05):9.[doi:10.3969/j.issn.1671-7414.2017.01.003]
[8]李 兵a,傅 尧a,符义富a,等.口腔鳞状细胞癌患者血清中CCL2和VEGF表达的初步研究[J].现代检验医学杂志,2017,32(04):64.[doi:10.3969/j.issn.1671-7414.2017.04.018]
 LI Binga,FU Yaoa,FU Yi-fua,et al.Preliminary Study on the Expression of CCL2 and VEGF in Serum of Patients with Oral Squamous Cell Carcinoma[J].Journal of Modern Laboratory Medicine,2017,32(05):64.[doi:10.3969/j.issn.1671-7414.2017.04.018]
[9]黄钰君,伍绍国,丘媛媛,等.广州地区正常儿童血清叶酸参考区间调查[J].现代检验医学杂志,2017,32(04):125.[doi:10.3969/j.issn.1671-7414.2017.04.036]
 HUANG Yu-jun,WU Shao-guo,QIU Yuan-yuan,et al.Investigation of the Normal Reference Range for Serum Folate of Healthy Children in Guangzhou Region[J].Journal of Modern Laboratory Medicine,2017,32(05):125.[doi:10.3969/j.issn.1671-7414.2017.04.036]
[10]武 琪a,陈 亮b,张宝华c.帕金森病患者血清和脑脊液褪黑素水平变化及其临床意义[J].现代检验医学杂志,2017,32(05):90.[doi:10.3969/j.issn.1671-7414.2017.05.017]
 WU Qia,CHEN Liangb,ZHANG Bao-huac.Changes and Clinical Significance of Melatonin in Blood and Cerebrospinal Fluid of Patients with Parkinson's Disease[J].Journal of Modern Laboratory Medicine,2017,32(05):90.[doi:10.3969/j.issn.1671-7414.2017.05.017]

备注/Memo

备注/Memo:
基金项目:陕西省教育厅自然科学研究项目(2013JK0782)。 作者简介:马 欢(1983-),女,本科,主治医师,研究方向:妇产科,E-mail:suimah@163.com。
更新日期/Last Update: 2019-10-20