[1]王 娇,张 杰,明春艳,等.食管癌患者血栓弹力图与常规凝血功能参数的相关性分析[J].现代检验医学杂志,2019,34(05):115-118.[doi:10.3969/j.issn.1671-7414.2019.05.028]
　WANG Jiao,ZHANG Jie,MING Chun-yan,et al.Correlation Analysis between Thromboelastography and Conventional Coagulation Indexes in Parameters with Esophageal Cancer[J].Journal of Modern Laboratory Medicine,2019,34(05):115-118.[doi:10.3969/j.issn.1671-7414.2019.05.028]
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食管癌患者血栓弹力图与常规凝血功能参数的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年05期
页码:
115-118
栏目:
论著
出版日期:
2019-10-29

文章信息/Info

Title:
Correlation Analysis between Thromboelastography and Conventional Coagulation Indexes in Parameters with Esophageal Cancer
文章编号:
1671-7414(2019)05-115-05
作者:
王 娇1; 张 杰2; 明春艳1; 赵茂吉1; 张 兵1
(1.四川省南充市中心医院检验科,四川南充 637000; 2.川北医学院第一附属医院生殖中心,四川南充 637000)
Author(s):
WANG Jiao1; ZHANG Jie2; MING Chun-yan1; ZHAO Mao-ji1; ZHANG Bing1
(1.Department of Clinical Laboratory,Nanchong Central Hospitalof Sichuan, Sichuan Nanchong 637000,China; 2.Reproductive Center,the First Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637000,China)
关键词:
血栓弹力图;  凝血功能;  相关性分析;  食管癌
分类号:
R735.1; R730.43
DOI:
10.3969/j.issn.1671-7414.2019.05.028
文献标志码:
A
摘要:
目的 探讨食管癌患者血栓弹力图(thromboelastography,TEG)与常规凝血功能参数之间的相关性。方法 选择2018年7月～2019年5月在南充市中心医院确诊的108例食管癌患者作为研究对象,入院后同时检测TEG、常规凝血功能及血细胞计数,并对检测结果进行相关回归分析。采用χ2检验比较TEG与常规凝血功能参数异常率的差异。结果 相关性分析显示食管癌患者的TEG参数中凝血反应时间(R)与活化部分凝血酶时间(APTT)和血细胞凝集块形成时间(K)呈正相关,与D-二聚体(D-D)、纤维蛋白(原)降解产物(FDPs)、血细胞凝块形成速率(α-Angle)、血凝块最大强度(MA)和凝血综合指数(CI)呈负相关; K与纤维蛋白原(FIB),D-D,FDPs,血小板计数(PLT),α-Angle,MA,CI呈负相关; α-Angle与FIB,D-D,FDPs,PLT,MA和CI呈正相关,与凝血酶时间(TT)呈负相关; MA与D-D,FIB,PLT和CI呈正相关; CI与FIB,D-D,FDPs和PLT呈正相关,与APTT和TT呈负相关。TEG检测与常规凝血功能检测异常率差异无统计学意义(P>0.05)。结论 TEG与常规凝血功能参数之间存在一定的相关性,结果具有一致性,二者不能相互替代,可及时为食管癌患者的凝血状态评估提供依据。
Abstract:
Objective To investigate the correlation between thromboelastography(TEG)and conventional coagulation parameters in patientswith esophageal cancer.Methods A total of 108 patients with esophageal cancer diagnosed in the Central Hospital of Nanchong from July 2018 to May 2019 were enrolled.TEG,routine coagulation function and blood test were detected at the time of admission.Linear correlation and regression analysis was performed among these parameters.The χ2 test was used to compare the difference between the abnormal rate of TEG and conventional coagulation parameters.Results Correlation analysis showed that the R value in the TEG parameters of patients with esophageal cancer was positively correlated with APTT and K,and negatively correlated with D-D,FDPs,α-Angle,MAand CI.K was negatively correlated with FIB,D-D,FDPs,PLT,α-Angle,MA and CI.α-Angle was positively correlated with FIB,DD,FDPs,PLT,MA and CI,and negatively correlated with TT.MA was positively correlated with DD,FIB,PLTand CI.CI was positively correlated with FIB,DD,FDPs and PLT,and negativelycorrelated with APTT and TT.There was no significant difference in the abnomalrate between TEG and conventional coagulation(P>0.05).Conclusion There were significant correlation between TEG and conventional coagulation parameters,and the results were consistent.The two methods can notreplace each other,which can provide the basis for the evaluation of coagulation status in patients with esophageal cancer.

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备注/Memo

备注/Memo:
作者简介:王 娇(1991-),女,硕士研究生,初级检验师,主要从事临床血液学工作,E-mail:JIAOW1991@163.com。 通讯作者:张 兵(1970-),男,博士研究生,副主任检验师,主要从事临床血液学工作,E-mail:3221454931@qq.com。
更新日期/Last Update: 2019-10-20