[1]刘文静,孙宏莉,张小江,等.2009~2018年北京协和医院布鲁菌感染的临床与实验室特点分析[J].现代检验医学杂志,2019,34(06):126-129.[doi:10.3969 / j.issn.1671-7414.2019.06.032]
 LIU Wen-jing,SUN Hong-li,ZHANG Xiao-jiang,et al.Analysis of Clinical and Laboratory Features of Brucella Infection in Peking Union Medical College Hospital from 2009 to 2018[J].Journal of Modern Laboratory Medicine,2019,34(06):126-129.[doi:10.3969 / j.issn.1671-7414.2019.06.032]
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2009~2018年北京协和医院布鲁菌感染的临床与实验室特点分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
126-129
栏目:
检验与临床
出版日期:
2019-12-30

文章信息/Info

Title:
Analysis of Clinical and Laboratory Features of Brucella Infection in Peking Union Medical College Hospital from 2009 to 2018
文章编号:
1671-7414(2019)06-126-05
作者:
刘文静12孙宏莉12张小江12王 瑶12杨启文12窦红涛12
(1. 中国医学科学院 北京协和医学院 北京协和医院检验科,北京 100730; 2. 北京市侵袭性真菌病机制研究与精准诊断重点实验室,北京 100730)
Author(s):
LIU Wen-jing12SUN Hong-li12ZHANG Xiao-jiang12WANG Yao12YANG Qi-wen12DOU Hong-tao12WANG He12ZHAO Ying12GUO Li-na12LIU Ya-li12Z
(1. Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China; 2. Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases,Beijing 100730,China)
关键词:
布鲁菌布鲁菌病凝集实验流行病学
分类号:
R378.5;R446.5
DOI:
10.3969 / j.issn.1671-7414.2019.06.032
文献标志码:
A
摘要:
目的 分析布鲁菌感染的临床与实验室特点,为其临床诊治提供依据。方法 回顾性分析2009~2018 年北京 协和医院134 例布鲁菌感染患者的临床和实验室资料,对其流行病学特征(包括年龄、性别、接触史、时间分布)、临 床表现和疗效进行分析。结果 134 例患者中男性88 例,女性46 例,平均年龄48 岁(1~78 岁)。50% 患者有明确生 活在疫区、接触牲畜、生牛羊肉及食用未灭菌奶制品等方面接触史。布鲁菌感染临床表现前三位的症状和体征为发热(66 例)、关节痛和/ 或肌肉痛伴乏力(23 例)、心脏疾病(10 例)。布鲁菌感染急性期经规范治疗多可治愈,若治疗不 及时或不规范可转为慢性。206 例送检阳性标本,住院99 例、门诊62 例和急诊45 例。布鲁菌分离前三位的科室为感 染内科(49 例)、急诊科(34 例)和普通内科(11 例)。外周血送检比率最高,需氧血培养瓶阳性报警时间均值为 88.12h(2~481h)。其他培养阳性标本包括组织、骨髓、脑脊液、关节液和玻璃体等。布鲁菌培养与血清凝集实验结果 一致性高,两种方法均送检的有83 例,其中82 例两种方法均阳性,仅1 例培养阳性,血清凝集实验阴性。十年间布鲁 菌培养阳性分离率最高的年度是2015~2017 年,阳性分离率最高的季节是4 月至7 月。结论 布鲁菌感染的临床表现复杂, 分离出布鲁菌是确诊的依据之一,需要综合考虑患者的基本情况和药物的毒副作用选择药物。掌握布鲁菌感染的临床和 实验室特征十分重要。
Abstract:
Objective The clinical and laboratory characteristics of Brucella infection were analyzed to provide basis for clinical diagnosis and treatment. Methods The clinical and laboratory data of 134 patients with Brucella infection in Peking Union Medical College Hospital from 2009 to 2018 were retrospectively analyzed. The epidemiological characteristics (including age, sex, contact history, time distribution), clinical manifestations and therapeutic effects were analyzed. Results In the134 Brucellosis patients, 88 were male and 46 were female with an average age of 48 years (1~78 years). Only 50% of the patients had a clear history of living in epidemic areas, contact with livestock, raw beef and mutton, and eating unsterilized dairy products. The first three clinical symptoms and signs were fever (66 cases), arthralgia and muscle pain with fatigue (23 cases), and heart disease (10 cases). Most cases of acute Brucella infection could be cured by standard treatment. If the treatment was not timely or standardized, they could become chronic. 206 positive samples distribution was 99 in hospital, 62 in outpatient department and 45 in emergency department, respectively. The top three departments of Brucella infection were infectious medicine (49 cases), emergency medicine (34 cases) and general medicine (11 cases). Peripheral blood was the highest isolated sample type,the average alarm time of aerobic blood culture bottle was 88.12h (2~481h). Brucella was also isolated from other sample types such as tissues, bone marrow, cerebrospinal fluid, joint fluid and vitreous body. Brucella culture and serum agglutination test was in high consistency, only one of 83 patients with two methods was positive in culture but negative in serum agglutination test. The highest positive isolation rate of Brucella in the past ten years was from 2015 to 2017, and the highest positive isolation season was from April to July. Conclusion The clinical manifestations of Brucella infection are complex. Isolation of Brucella is one of the bases for its diagnosis. It is necessary to consider the basic situation of patients and the side effects of drugs to choose drugs. And it’s important to master the clinical and laboratory epidemiological characteristics of Brucella infection.

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备注/Memo

备注/Memo:
作者简介:刘文静(1984-),女,硕士学位,助理研究员,研究方向:常见病原菌快速鉴定及耐药机制研究,E-mail:liuwenjing1220@139.com。 通信作者:徐英春(1964-),男,本科,研究员,研究方向:常见病原菌快速鉴定及耐药机制研究,E-mail: xycpumch@139.com 收稿日期:2019-07-14
更新日期/Last Update: 2019-12-25