[1]余成强,李步荣,何家花,等.陕西省商洛地区孕早期妇女甲状腺功能参考范围的初步建立和应用研究[J].现代检验医学杂志,2020,35(02):139-141.[doi:10.3969/j.issn.1671-7414.2020.02.038]
 YU Cheng-qiang,LI Bu-rong,HE Jia-hua,et al.Preliminary Study on Thyroid Function Reference Ranges of PregnantWomen During Early Pregnancy in Shangluo[J].Journal of Modern Laboratory Medicine,2020,35(02):139-141.[doi:10.3969/j.issn.1671-7414.2020.02.038]
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陕西省商洛地区孕早期妇女甲状腺功能参考范围的初步建立和应用研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年02期
页码:
139-141
栏目:
检验与临床
出版日期:
2020-05-24

文章信息/Info

Title:
Preliminary Study on Thyroid Function Reference Ranges of PregnantWomen During Early Pregnancy in Shangluo
文章编号:
1671-7414(2020)02-142-03
作者:
余成强12李步荣1何家花2刘晓良2赵 芳2
(1. 西安交通大学第二附属医院医学检验科,西安 710004;2. 商洛市中心医院医学检验科,陕西商洛 726000)
Author(s):
YU Cheng-qiang12 LI Bu-rong1 HE Jia-hua2 LIU Xiao-liang2ZHAO Fang2
(1.Department of Medical Laboratory,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an710004,China;2.Department of Medical Laboratory, Shangluo Central Hospital, Shaanxi Shangluo 726000,China)
关键词:
孕早期甲状腺功能参考范围电化学发光法
分类号:
R446.11;R392.11
DOI:
10.3969/j.issn.1671-7414.2020.02.038
文献标志码:
A
摘要:
目的 调查商洛地区健康妇女孕早期甲状腺功能各指标的水平,探究方法学特异性的参考范围,并对比该调查获得的参考范围和成人参考范围在检出孕早期甲状腺功能异常的差异。方法 选取2018 年7 月~ 2019 年3 月在商洛市中心医院产科例行产检的386 例健康的孕早期单胎孕妇作为实验组,另选取146 例同期体检的非妊娠的健康女性作为对照组,采用国际推荐的电化学发光法测定受试者血清中 TSH,FT4,FT3,TT3,TT4,TPOAb 及TG 水平。结果 孕早期甲状腺功能各指标中位数及95% 参考范围:TSH 为1.90(0.05 ~ 4.09)uIU/ml,FT4 为16.99(13.43 ~ 22.64)pmol/L,FT3为4.55(3.47 ~ 5.71)pmol/L,TT4 为133.70(86.62 ~ 194.06)nmol/L,TT3 为2.38(1.58 ~ 3.48)nmol/L,TPOAb 为10.03(0 ~ 21.89)IU/ml, TG 为8.37(0.32 ~ 28.09)ng/ml。与对照组相比,TSH, TT3, TT4, TPOAb 及TG[2.35(0.86~4.16)uIU/ml, 1.81(1.31~2.40)nmol/L,104.75(76.33~142.64)nmol/L, 11.02(0~30.30)IU/ml 和6.86(0.29~31.79)ng/ml] 差异均有统计学意义(U=7 917.5~23 950, 均P<0.05),FT4, FT3[4.50(3.38~5.61)pmol/L,17.20(13.37~22.21)pmol/L] 差异无统计学意义(U=26 688~27 337.5,P>0.05)。使用本研究建立的参考范围和正常成人的参考范围,对 458 例孕早期产检的孕妇进行筛查,甲状腺功能异常检出率[n(%)] 分别为:甲状腺功能亢进症9(1.97%)& 14(3.06%),亚临床甲状腺功能亢进症 3(0.66%)&15(3.28%),甲状腺功能减退症4(0.87%)& 1(0.22%),亚临床甲状腺功能减退症40(8.73%)& 44(9.61%),低甲状腺素血症 13(2.84%)& 3(0.66%)。结论 商洛市健康女性孕早期甲状腺功能各指标参考范围不同于非妊娠女性,建立该地区孕早期特异性的参考范围具有重要的临床意义。

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备注/Memo

备注/Memo:
作者简介:余成强(1985-),男,大学本科,在读硕士,主管检验师,从事临床免疫与分子生物学检测工作,E-mail:79395028@qq.com。通讯作者:李步荣(1972-),男,医学博士,主任检验师,硕士生导师,主要从事病毒分子生物学诊断工作,E-mail:liburong@163.com。收稿日期:2019-09-02修回日期:2019-12-01
更新日期/Last Update: 2020-04-30