[1]马苑真,董 莉.动脉粥样硬化相关血清生物化学及分子生物学检测指标的最新研究进展[J].现代检验医学杂志,2020,35(03):160-164.[doi:10.3969 / j.issn.1671-7414.2020.03.043]
 MA Yuan-zhen,DONG LI.Recent Advances in the Detection of Serum Biochemistry and Molecular Biology of Atherosclerosis[J].Journal of Modern Laboratory Medicine,2020,35(03):160-164.[doi:10.3969 / j.issn.1671-7414.2020.03.043]
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动脉粥样硬化相关血清生物化学及分子生物学检测指标的最新研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
160-164
栏目:
综 述
出版日期:
2020-07-20

文章信息/Info

Title:
Recent Advances in the Detection of Serum Biochemistry and Molecular Biology of Atherosclerosis
文章编号:
1671-7414(2020)03-160-05
作者:
马苑真 董 莉
(内蒙古医科大学附属医院检验科,呼和浩特 010050)
Author(s):
MA Yuan-zhen DONG LI
(Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050,China)
关键词:
动脉粥样硬化S100 钙结合蛋白小分子RNA金属基质蛋白酶MMP-9微粒白细胞介素-33
分类号:
R543.5;R446.11
DOI:
10.3969 / j.issn.1671-7414.2020.03.043
摘要:
动脉粥样硬化是一种在人群中发病率较高的疾病,可以累及全身各处动脉引起相应的并发症,严重危害群体健 康。传统的动脉粥样硬化的血清学检测指标仅有助于危险因素的检出,特异度较差。随着研究的进展,新发现许多血清 学指标与动脉粥样硬化的发生发展相关,有可能为之后的诊断及后续的靶点治疗提供新的思路和方法,该文就新发现的 与动脉粥样硬化相关的血清生物化学及分子生物学检测指标包括S100 钙结合蛋白A8 和A9,小分子RNA, 金属基质蛋 白酶MMP-9, 微粒MPs 及白细胞介素33 进行综述。
Abstract:
Atherosclerosis is a disease with high incidence in the population, which can involve the arteries all over the body cause corresponding complications seriously endanger the health of the population. It also can develop into other diseases such as angina , myocardial infarction and cerebral infarction.Traditional serum indexes are helpful to the detection of risk factors, but lack of specificity.With the development of the research, many serum indexes related to atherosclerosis were found and will give some new thoughts and methods on the diagnosis and target therapy for atherosclerosis.This article reviews the research progress of biochemical and molecular biological indicators related to atherosclerosis including S100 calcium-binding protein A8 / A9,MicroRNA, matrix metalloproteinase-9(MMP-9), microparticles (MPs) and interleukin-33 (IL-33).

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备注/Memo

备注/Memo:
收稿日期:2020-03-30 修回日期:2020-04-05作者简介:马苑真(1995-),女,在读硕士研究生,学士学位,专业:临床疾病检验诊断学,E-mail:327498342@qq.com。 通讯作者:董莉(1964-),女,主任检验师,硕士研究生导师,E-mail:dongsuanzhi@163.com。
更新日期/Last Update: 2020-07-20