[1]汪学耀,张 波,荆成宝.胸腔积液ADA,ADA2 及ACE 水平检测对结核性和恶性胸腔积液的鉴别诊断价值[J].现代检验医学杂志,2020,35(04):57-60.[doi:10.3969/j.issn.1671-7414.2020.04.014]
 WANG Xue-yao,ZHANG Bo,JING Cheng-bao.Differential Diagnosis Value of Pleural Effusion ADA, ADA2 and ACE Levels in Tuberculous and Malignant Pleural Effusion[J].Journal of Modern Laboratory Medicine,2020,35(04):57-60.[doi:10.3969/j.issn.1671-7414.2020.04.014]
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胸腔积液ADA,ADA2 及ACE 水平检测对结核性和恶性胸腔积液的鉴别诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年04期
页码:
57-60
栏目:
论 著
出版日期:
2020-09-05

文章信息/Info

Title:
Differential Diagnosis Value of Pleural Effusion ADA, ADA2 and ACE Levels in Tuberculous and Malignant Pleural Effusion
文章编号:
1671-7414(2020)04-057-04
作者:
汪学耀1张 波2荆成宝3
(1. 安康市汉滨区第三人民医院,陕西安康 725000;2. 安康市中医医院,陕西安康 725000;3. 安康市中心医院,陕西安康 725000)
Author(s):
WANG Xue-yao1ZHANG Bo2JING Cheng-bao3
(1. Hanbin District Third People’s Hospital of Ankang, Shaanxi Ankang 725018, China;2. Ankang Hospital of Traditional Chinese Medicine, Shaanxi Ankang 725000, China;3. Ankang Central Hospital, Shaanxi Ankang 725000, China)
关键词:
胸腔积液腺苷脱氨酶腺苷脱氨酶同工酶2血管紧张素转化酶
分类号:
R446.19
DOI:
10.3969/j.issn.1671-7414.2020.04.014
文献标志码:
A
摘要:
目的 探讨胸腔积液腺苷脱氨酶(adenosine deaminase,ADA)、腺苷脱氨酶同工酶2(adenosine deaminaseisozyme 2,ADA2)及血管紧张素转化酶(angiotensin converting enzyme,ACE)水平检测对结核性和恶性胸腔积液的鉴别诊断价值。方法 选取安康市汉滨区第三人民医院2018 年1 月~2019 年12 月52 例胸腔积液确诊患者,采用酶显色测定法测定ADA,ADA2,采用连续监测法测定ACE。使用受试者工作特征(ROC)曲线,并计算曲线下面积(AUC)评估ADA,ADA2 和ACE 活性水平对结核性与恶性胸腔积液鉴别诊断的意义。结果 ADA2,ACE 和ADA 活性水平,结核性胸腔积液患者分别为47.17±26.22,52.73±30.07 和59.90±35.72 U/L,恶性胸腔积液患者分别为17.70±7.82,24.18±8.94 和20.48±6.91 U/L,结核性胸腔积液患者胸腔积液中ACE,ADA2 和ADA 活性水平高于恶性胸腔积液患者,差异均有统计学意义(t=4.85 ~ 5.808,均P < 0.001);ACE,ADA 和ADA2 曲线下面积分别为0.865,0.881 和0.899,对鉴别结核性与恶性胸腔积液均有意义,ADA2 的鉴别诊断效能较高;ADA2 联合ADA,ADA2 联合ACE,ADA 联合ACE 的曲线下面积依次为0.875,0.942 和0.952,ADA 联合ACE 的鉴别诊断效能较高。结论 ADA,ADA2 和ACE对鉴别诊断结核性与恶性胸腔积液均有意义;单指标中ADA2 和联合指标中ADA 联合ACE 的鉴别诊断效能较高。

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备注/Memo

备注/Memo:
收稿日期:2020-06-29修回日期:2020-07-17作者简介:汪学耀(1980-),男,在读研究生,副主任检验技师,主要从事细胞形态学研究。通讯作者:荆成宝,E-mail:jykjcb@126.com。
更新日期/Last Update: 2020-10-08