[1]赵　莉,白延平,谢园媛.急性冠状动脉综合征（ACS）患者血清 miR-186-5p，miR-23 和 miR-652 水平检测的临床意义[J].现代检验医学杂志,2020,35(06):64-67.[doi:doi:10.3969/j.issn.1671-7414.2020.06.016]
　ZHAO Li,BAI Yan-ping,XIE Yuan-yuan.Clinical Value of Serum miR-186-5p, miR-23b and miR-652 Levels in Patientswith Acute Coronary Syndrome (ACS)[J].Journal of Modern Laboratory Medicine,2020,35(06):64-67.[doi:doi:10.3969/j.issn.1671-7414.2020.06.016]
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急性冠状动脉综合征（ACS）患者血清 miR-186-5p，miR-23 和 miR-652 水平检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
64-67
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Clinical Value of Serum miR-186-5p, miR-23b and miR-652 Levels in Patientswith Acute Coronary Syndrome (ACS)
文章编号:
1671-7414（2020）06-064-05
作者:
赵　莉; 白延平; 谢园媛
（延安大学附属医院，陕西延安 716000）
Author(s):
ZHAO Li ;  BAI Yan-ping ;  XIE Yuan-yuan
（ Affiliated Hospital of Yan’an University, Shaanxi Yan’an 716000, China ）
关键词:
急性冠状动脉综合征;  miR-186-5p; miR-23b; miR-652; 诊断价值
分类号:
R543.3；R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.016
文献标志码:
A
摘要:
目的　探讨急性冠状动脉综合征（acute coronary syndrome，ACS）患者血清 miR-186-5p， miR-23b 和 miR-652水平检测的临床意义。方法　选择 2016 年 1 月 ~2018 年 1 月在延安大学附属医院行经皮冠状动脉介入治疗 (percutaneouscoronary intervention，PCI) 手术的 ACS 患者 68 例作为观察组，另外选取同期做冠脉造影符合冠心病诊断，但排除 ACS的患者 68 例作为对照组。收集两组受试对象外周血，检测血清中 miR-186-5p, miR-23b 和 miR-652 水平，并进行相关性分析。绘制 ROC 曲线分析 miR-186-5p, miR-23b 和 miR-652 单个指标及联合使用诊断 ACS 的临床价值。结果　与对照组比较，观察组患者血清中 miR-186-5p，miR-23b 和 miR-652 水平均提高，差异有统计学意义（Z=3.312~6.451，均P<0.05）。不同病变支数的 ACS 患者血清中 miR-186-5p， miR-23b 和 miR-652 的水平比较不全相同，差异有统计学意义（F=6.017~8.151，均 P<0.05）。与术前比较，术后患者血清中 miR-186-5p，miR-23b 和 miR-652 水平显著降低，差异有统计学意义（Z=2.090~3.036，均 P<0.05）。ACS 患者血清中 miR-186-5p，miR-23b 和 miR-652 水平与 cTnI 呈显著相关（r=0.689，0.779，0.746，均 P=0.000)。其临界值、AUC，灵敏度和特异度，miR-186-5p 依次为 0.110，0.775，61.8% 和 91.2%；miR-23b 依次为 0.133，0.799，69.1% 和 88.2%；miR-652 依次为 0.164，0.789，67.6% 和 91.2%。三者联用 AUC，灵敏度和特异度分别为 0.941，91.2% 和 83.8%。cTnI 的 AUC 灵敏度和特异度分别为 0.857，76.5% 和79.4%。miRNAs 联合 AUC 显著高于 cTnI（Z=2.243, P<0.05）。结论　ACS 患者血清中 miR-186-5p, miR-23b 和 miR-652 水平升高，联合使用诊断 ACS 具有一定的临床价值。

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更新日期/Last Update: 2020-12-20