[1]颜宇飞,邓雪梅,刘明利,等.新型冠状病毒肺炎患者血液NLR，DD和 CRP水平联合检测对死亡风险的评估研究[J].现代检验医学杂志,2021,36(01):92-95.[doi:10.3969/j.issn.1671-7414.2021.01.023]
　YAN Yu-fei,DENG Xue-mei,LIU Ming-li,et al.Novel Coronavirus Pneumonia Patients’ Blood NLR, DD and CRP Levels Combined Detection for the Evaluation of Death Risk[J].Journal of Modern Laboratory Medicine,2021,36(01):92-95.[doi:10.3969/j.issn.1671-7414.2021.01.023]
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新型冠状病毒肺炎患者血液NLR，DD和 CRP水平联合检测对死亡风险的评估研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
92-95
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2021-02-05

文章信息/Info

Title:
Novel Coronavirus Pneumonia Patients’ Blood NLR, DD and CRP Levels Combined Detection for the Evaluation of Death Risk
文章编号:
1671-7414（2021）01-092-05
作者:
颜宇飞; 邓雪梅; 刘明利; 等
（1.上海市控江医院 a.检验科；b.急诊科；c.呼吸科 ,上海 200093；2.武汉市第三医院感染科，武汉 430000）
Author(s):
YAN Yu-fei;  DENG Xue-mei;  LIU Ming-li;  et al
(1a. Department of Laboratory Medicine; 1b.Emergency Department;1c.Department of Respiration, Shanghai Kongjiang Hospital, Shanghai 200093,China;2.Infectious Disease Department,the Third Hospital of Wuhan, Wuhan 430000,China)
关键词:
新型冠状病毒肺炎; 中性粒细胞 /淋巴细胞比值; D-二聚体; C反应蛋白; 死亡风险
分类号:
R373.19；R446.11
DOI:
10.3969/j.issn.1671-7414.2021.01.023
文献标志码:
A
摘要:
目的 探讨中性粒细胞 /淋巴细胞比值（ NLR）、D-二聚体（ DD）、C反应蛋白（ CRP）水平联合检测评估新型冠状病毒肺炎（ COVID-19）患者的死亡风险。方法 2020年 1月 28日～ 3月 5日在武汉第三医院救治的 COVID-19患者 146例，其中生存组 105例（普通型组 46例、重型组 25例、危重型组 34例），死亡组 41例，进行血细胞分析及 DD，CRP检测。采用 Mann-Whitney U检验、二元 Logistic回归、 Spearman相关分析、受试者工作特征（ROC）曲线等统计学方法，评估 NLR，DD，CRP单独及联合检测预测 COVID-19患者的死亡风险。结果 死亡组 NLR 13.18±23.31，DD 5.05±5.51 mg/L和 CRP102.84±120.99 mg/L明显高于生存组 (4.07±4.26,0.90±2.18 mg/ L ,34.33±92.40 mg/L)，差异均有统计学意义（ z=-5.682，-4.466，-4.350，均 P<0.05）；二元 Logistic回归分析显示 NLR，DD，CRP均是 COVID-19感染的独立危险因素（ OR=1.054，1.056，1.225），差异均有统计学意义（均 P<0.05）；相关分析显示 NLR与 DD（r=0.597）和 CRP（r=0.630）均呈正相关，差异均有统计学意义（均 P<0.05）； ROC曲线分析显示 NLR，DD，CRP联合检测的 AUC为 0.842，高于 NLR，DD和 CRP单独检测的 AUC（0.800，0.738和 0.732）。结论 NLR，DD和 CRP水平联合检测在预测 COVID-19患者的死亡风险中有较高的敏感度和特异度，弥补了单项检测的不足，在辅助诊断中有较高的价值。

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备注/Memo

备注/Memo:
作者简介：颜宇飞（1980-），男，本科，副主任技师，研究方向：临床检验、血液学检验， E-mail:597286712@qq.com。
刘明利（1984-），男，本科，副主任医师，研究方向：急诊临床医学 ,E-mail:395956184@qq.com,共同第一作者。
<br/>通讯作者：陈元菁，女，硕士，主任医师，Email:chenyj＿ 168@126.com。
更新日期/Last Update: