[1]蔡文灿,刘熙君,刘彦明,等.血清PLGF和sFLT-1水平联合检测对急性ST段抬高型心肌梗死患者PCI术后MACE复发的诊断价值研究[J].现代检验医学杂志,2021,36(02):66-69.[doi:doi:10.3969/j.issn.1671-7414.2021.02.016]
　CAI Wen-can,LIU Xi-jun,LIU Yan-ming,et al.Combined Detection of Serum PLGF and SFLT-1 Levels in the Diagnosis of MACE Recurrence after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction[J].Journal of Modern Laboratory Medicine,2021,36(02):66-69.[doi:doi:10.3969/j.issn.1671-7414.2021.02.016]
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血清PLGF和sFLT-1水平联合检测对急性ST段抬高型心肌梗死患者PCI术后MACE复发的诊断价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
66-69
栏目:
论　著
出版日期:
2021-04-30

文章信息/Info

Title:
Combined Detection of Serum PLGF and SFLT-1 Levels in the Diagnosis of MACE Recurrence after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction
文章编号:
1671-7414（2021）02-066-04
作者:
蔡文灿; 刘熙君; 刘彦明; 等
（粤北人民医院a.输血科；b.检验科，广东韶关 512026）
Author(s):
CAI Wen-can; LIU Xi-jun; LIU Yan-ming;  et al
（a. Department of Blood Transfusion；b. Department of Clinical Laboratory, Yuebei People’s Hospital , Guangdong Shaoguan 512026, China）
关键词:
胎盘生长因子; 可溶性fms样酪氨酸激酶-1; 急性ST段抬高型心肌梗死
分类号:
R541.6；R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.016
文献标志码:
A
摘要:
目的　探讨血清胎盘生长因子（PLGF）和可溶性fms样酪氨酸激酶-1(sFLT-1)在急性ST段抬高型心肌梗死（ST-AMI）患者经皮冠状动脉介入治疗（PCI）后心血管不良事件（MACE）复发中的价值。方法　选取2018年1月~2019年1月收治的ST-AMI患者230例作为研究对象，入院后均及时进行PCI治疗，入院后第12日检测PLGF和sFLT-1水平并随访一年。根据随访期间内是否复发MACE，研究对象被分为MACE组（68例）和对照组（162例），比较两组间血清PLGF和sFLT-1水平并分析其对ST-AMI患者PCI术后MACE复发的价值。结果　MACE组的PLGF和sFLT-1检测水平分别为22.56±5.99 pg/ml和189.58±69.94 pg/ml；对照组的PLGF和sFLT-1检测水平分别为32.71±7.90 pg/ml和141.52±59.76 pg/ml，结果显示MACE组的PLGF表达水平明显低于对照组，差异具有统计学意义（t=10.57，P<0.000 1）；而sFLT-1表达水平明显高于对照组，差异具有统计学意义（t=5.372，P<0.000 1）。血清PLGF和sFLT-1单独检测的灵敏度、特异度和ROC曲线下面积（AUROC）分别为80.25%，53.47%，0.766 和74.07%，58.82%，0.697，联合检测的灵敏度、特异度和AUROC分别为77.90%，72.8%和0.820。结论　血清PLGF和sFLT-1检测可用于ST-AMI患者PCI术后MACE复发的早期诊断且联合检测的灵敏度和特异度更高。

参考文献/References:

[1] ANDERSON J L, MORROW D A. Acute myocardial infarction[J]. New England Journal of Medicine, 2017, 376(21): 2053-2064.
[2] 宋倩，张雯．急性心肌梗死患者血浆PCSK9水平对临床不良事件发生的预测价值分析[J].现代检验医学杂志, 2020, 35(3):72-77. SONG Qian, ZHANG Wen. Analysis of the predictive value of plasma PCSK9 level on clinical adverse events in patients with acute myocardial infarction [J]. Journal of Modern Laboratory Medicine, 2020,35(3):72-77.
[3] OZAKI Y, KATAGIRI Y, ONUMA Y, et al. CVIT expert consensus document on primary percutaneous coronary intervention(PCI)for acute myocardial infarction(AMI) in 2018[J]. Cardiovascular Intervention and Therapeutics, 2018, 33(2): 178-203.
[4] ROSELL O F, MELLADO V J, FERNáNDEZ V P, et al. Initial complications and factors related to prehospital mortality in acute myocardial infarction with ST segment elevation[J]. Emergency Medicine Journal, 2015, 32(7): 559-563.
[5] ZHANG Fucheng, SU Shuhong, HOU Yuyan, et al. Effects (MACE and bleeding events) of ticagrelor combined with omeprazole on patients with acute myocardial infarction undergoing primary PCI [J]. Hellenic Journal of Cardiology, 2020,61（5）：306-310.
[6] HUPFELD C，MUDALIAR S . Navigating the “MACE” in cardiovascular outcomes trials and decoding the relevance of atherosclerotic cardiovascular disease benefits versus heart failure benefits[J]. Diabetes Obesity & Metabolism, 2019, 21(8): 1780-1789.
[7] VAN BERGEN T, ETIENNE I, CUNNINGHAM F, et al. The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases [J]. Progress in Retinal and Eye Research, 2019, 69: 116-136.
[8] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会, 《中国循环杂志》编辑委员会. 急性心肌梗死诊断和治疗指南 [J]. 中华心血管病杂志, 2001, 29(12):710-725. Chinese Society of Cardiovascular of Chinese Medical Association, Editorial Board of the Chinese Journal of Cardiovascular Diseases, the Editorial Board of the Chinese Journal of Circulation. The guidelines for diagnosis and treatment of acute myocardial infarction [J]. Chinese Journal of Cardiovascular Disease, 2001, 29(12):710-725.
[9] DODSON J A, GEDA M, KRUMHOLZ H M, et al. Design and rationale of the comprehensive evaluation of risk factors in older patients with AMI (SILVER-AMI) study [J]. BMC Health Services Research, 2014, 14(1):506.
[10] 刘亚东, 冯莉莉, 王海晶, 等．冠心病患者血清Lp-PLA2与HCY检测及其与冠状动脉病变程度的相关性分析[J]．现代检验医学杂志，2018，33（6）：83-87． LIU Yadong, FENG Lili, WANG Haijing, et al. Detection of serum Lp-PLA2 and HCY in patients with coronary heart disease and its correlation with the degree of coronary artery disease [J]. Journal of Modern Laboratory Medicine, 2018,33(6):83-87.
[11] LEA.OS-MIRANDA A, NOLASCO-LEA.OS A G, CARRILLO-JUáREZ R I, et al . Usefulness of the sFlt-1/PlGF (Soluble fms-Like Tyrosine Kinase-1/Placental Growth Factor) ratio in diagnosis or misdiagnosis in women with clinical diagnosis of preeclampsia[J]. Hypertension (Dallas, Tex. : 1979), 2020, 76(3):892-900.
[12] NGUYEN J T,VAKIL K, ADABAG S,et al. Hospital Readmission rates following AMI: potential interventions to improve efficiency[J]. Southern Medical Journal, 2018, 111(2):93-97.
[13] DO.AN C, BAYRAM1 Z, .AP M,et al. Comparison of 30-day MACE between immediate versus staged complete revascularization in acute myocardial infarction with multivessel disease, and the effect of coronary lesion complexity[J]. Medicina, 2019, 55(2):51.
[14] STROBL F F, KUHLIN B, STAHL R, et al. Intracranial arterial calcifications as a prognostic factor for subsequent major adverse cardiovascular events(MACE)[J]. La Radiologia Medica, 2018, 123(6): 456-462.
[15] HUDSON M. In suspected AMI,an extended algorithm increased sensitivity and decreased specificity for predicting 30-day MACE[J]. Annals of Internal Medicine, 2020, 172(2): JC11.
[16] HUNTER B R. Nice algorithms based on high sensitivity troponin assays ruled out AMI but>8.5% had MACE at 30 d[J].Ann Intern Med, 2016, 165(8): JC47.
[17] ROMERO J, LUPERCIO F, DíAZ J C,et al. Microvascular obstruction detected by cardiac MRI after AMI for the prediction of LV remodeling and MACE: A meta-analysis of prospective trials[J]. International Journal of Cardiology, 2016, 202:344-348.
[18] DEWERCHIN M,CARMELIET P. PlGF: A multitasking cytokine with disease-restricted activity[J]. Cold Spring Harbor Perspectives in Medicine, 2012, 2(8) : a011056.
[19] NEJABATI H R, LATIFI Z, GHASEMNEJAD T, et al. Placental growth factor(PlGF) as an angiogenic/inflammatory switcher:lesson from early pregnancy losses[J]. Gynecological Endocrinology, 2017, 33(9): 668-674.
[20] LECARPENTIER E, TSATSARIS V. Angiogenic balance(sFlt-1/PlGF)and preeclampsia[J]. Annales d’ Endocrinologie, 2016, 77(2): 97-100.
[21] ZEISLER H, HUND M, VERLOHREN S. The sFlt-1:PlGF ratio in women with suspected preeclampsia[J]. New England Journal of Medicine, 2016, 374(18): 1785-1786.
[22] 史静怡, 丁邵祥, 赵志林, 等.冠状动脉慢血流与外周血淋巴细胞和单核细胞比值之间的关联性分析[J].现代检验医学杂志, 2020, 35(1): 139-142, 145. SHI Jingyi, DING Shaoxiang, ZHAO Zhilin, et al. Association of slow coronary flow with peripheral blood lymphocyte-to-monocyte ratio[J]. Journal of Modern Laboratory Medicine,2020,35(1):139-142,145.
[23] 雷新宇，张志岗．胎盘生长因子在急性ST段抬高心肌梗死中的临床意义及与左室功能关系的研究[J].中国药物与临床, 2018, 18(8): 1362-1363. LEI Xinyu, ZHANG Zhigang. The clinical significance of placental growth factor in acute ST-segment elevation myocardial infarction and its relationship with left ventricular function[J]. Chinese Remedies & Clinics ,2018,18(8):1362-1363.
[24] 彭雪，王文娟，牛洁婷．慢性心力衰竭病人PLGF和sFlt-1水平变化及与短期预后的关系探讨[J]．中西医结合心脑血管病杂志，2019，17（24）：3995-3999． PENG Xue, WANG Wenjuan, NIU Jieting. Study on the relationship between PLGF and SFLT-1 levels and short-term prognosis in patients with chronic heart failure[J]. Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease, 2019,17(24):3995-3999.
[25] KODAMA Y, KITTA Y, NAKAMURA T,et al. Atorvastatin increases plasma soluble Fms-like tyrosine kinase-1 and decreases vascular endothelial growth factor and placental growth factor in association with improvement of ventricular function in acute myocardial infarction[J]. Journal of the American College of Cardiology, 2006, 48(1):43-50.
[26] HOCHHOLZER W, REICHLIN T, STELZIG C,et al. Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratification and early diagnosis in patients with suspected acute myocardial infarction[J]. European Heart Journal, 2011, 32(3):326-335.

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备注/Memo

备注/Memo:
基金项目：韶关市卫生和计划生育委员会科研项目（Y19041）。
作者简介：蔡文灿（1964-），男，学士，副主任技师，研究方向：心脏标志物，E-mail：wencancai@126.com。
更新日期/Last Update: 2021-04-10