[1]罗晓琴,江 平,程时磊.青海地区育龄女性MTHFR基因C677位点的多态性研究[J].现代检验医学杂志,2021,36(02):89-91.[doi:doi:10.3969/j.issn.1671-7414.2021.02.021]
 LUO Xiao-qin,JIANG Ping,CHENG Shi-lei.Study on the Polymorphism Distribution of MTHFR Gene C677 in Women of Childbearing Age in Qinghai[J].Journal of Modern Laboratory Medicine,2021,36(02):89-91.[doi:doi:10.3969/j.issn.1671-7414.2021.02.021]
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青海地区育龄女性MTHFR基因C677位点的多态性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
89-91
栏目:
论 著
出版日期:
2021-04-30

文章信息/Info

Title:
Study on the Polymorphism Distribution of MTHFR Gene C677 in Women of Childbearing Age in Qinghai
文章编号:
1671-7414(2021)02-089-04
作者:
罗晓琴江 平程时磊
(青海省人民医院分子病理科,西宁 810007)
Author(s):
LUO Xiao-qin JIANG Ping CHENG Shi-lei
(Department of Molecular Pathology,Qinghai Provincial People’s Hospital ,Xining 810007,China)
关键词:
510-亚甲基四氢叶酸还原酶C677T基因多态性青海地区
分类号:
R714.1;Q786
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.021
文献标志码:
A
摘要:
目的 分析青海地区育龄女性叶酸代谢关键酶5,10亚甲基四氢叶酸还原酶(methylene tetra hydro folate reductase, MTHFR)基因C677多态性的分布特点,指导育龄女性合理补充叶酸。方法 实时荧光定量PCR检测技术分析叶酸代谢相关酶基因MTHFR位点C677的多态性。结果 青海地区孕前及孕早期女性TT纯合突变基因型频率(20.72%)与不孕症女性(18.68%)差异无统计学意义(χ2=2.52,P>0.05)。青海地区汉族女性MTHFR位点纯合突变基因型TT频率(20.70%)同青海地区藏族女性TT纯合基因型频率(11.65%)差异有统计学意义(χ2=25.06,P<0.05),而与回族(19.91%)和土族(20.72%)差异无统计学意义(χ2=1.56,1.14,均P>0.05)。青海地区汉族女性TT纯合基因型频率(20.70%)与西藏汉族女性(20.43%)差异无统计学意义(χ2=0.86,P>0.05),与低海拔地区[辽源(28.76%)、淄博(43.61%)、郑州(36.78%)、南宁(7.71%)、佛山(27.70%)和琼海(6.14%)]差异均有统计学意义(χ2=20.58~493,均P<0.05)。结论 青海地区育龄女性的叶酸代谢相关基因MTHFR的分布具有海拔特异性及民族特异性,且孕前及孕早期女性与不孕症女性无相关性(P>0.05)。

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备注/Memo

备注/Memo:
作者简介:罗晓琴(1990-),女,学士,检验技师,主要从事医学检验,E-mail:1178616179@qq.com。
更新日期/Last Update: 2021-04-10