[1]宋秀英,樊阳阳,赵 莉,等.多囊卵巢综合征患者血清 Spexin 水平表达及其与多项生理生化指标的相关性分析[J].现代检验医学杂志,2021,36(03):80-82.[doi:10.3969/j.issn.1671-7414.2021.03.018]
 SONG Xiu-ying,ZHAO Li,CAO Yang-yang,et al.Expression of Serum Spexin in Patients with Polycystic Ovary Syndrome andIts Correlation with Multiple Physiological and Biochemical Indexes[J].Journal of Modern Laboratory Medicine,2021,36(03):80-82.[doi:10.3969/j.issn.1671-7414.2021.03.018]
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多囊卵巢综合征患者血清 Spexin 水平表达及其与多项生理生化指标的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
80-82
栏目:
论 著
出版日期:
2021-05-31

文章信息/Info

Title:
Expression of Serum Spexin in Patients with Polycystic Ovary Syndrome andIts Correlation with Multiple Physiological and Biochemical Indexes
文章编号:
1671-7414(2021)03-080-04
作者:
宋秀英樊阳阳赵 莉
(1. 西安高新医院妇科,西安 710075;2. 陕西省人民医院产科,西安 710068)
Author(s):
SONG Xiu-ying1 ZHAO Li1 CAO Yang-yang1 FAN Yang-yang2
(1.Department of Gynaecology, Xi’an Gaoxin Hospital, Xi’an 710075, China;2. Department of Obstetrics, ShaanxiProvincial People’s Hospital, Xi’an 710068, China)
关键词:
多囊卵巢综合征Spexin身体质量指数
分类号:
R711.75;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.03.018
文献标志码:
A
摘要:
目的 探究多囊卵巢综合征 (polycystic ovarian syndrome, PCOS) 患者血清 Spexin 水平表达及其与多项生理生化指标的相关性。方法 选取西安高新医院 2018 年 9 月~ 2019 年 10 月收治的 60 例 PCOS 患者为观察组,另选取同期体检健康者 60 例为对照组,采用全自动生化分析仪检测受试者的总胆固醇 (total cholesterol, TC) 和低密度脂蛋白胆固醇(low density lipoprotein-cholesterin, LDL-C),采用电化学发光免疫分析法 (ECLIA) 测定血清卵泡刺激素 (follicle-stimulatinghormone, FSH) 和雌二醇 (estradiol, E2) 的水平,采用酶联免疫吸附试验 (ELISA) 测定血清 Spexin 水平。根据血清 Spexin水平的不同将受试者又分为低表达组 (Spexin ≤ 2.8 ng/ml) 和高表达组 (Spexin>2.8 ng/ml) 两组。比较两组的一般资料,Spexin 高、低表达组多项生理生化指标并采用 Spearman 相关性检验分析其相关性。结果 两组的生化指标比较差异无统计学意义 (t=0.04~1.71,均 P > 0.05),观察组血清 Spexin 水平 5.26±0.37 ng/ml 显著高于对照组 2.74±0.21 ng/ml,差异具有统计学意义 (t=11.63,P < 0.05)。Spexin 高、低表达组的 TC,LDL-C,FSH 和 E2 的差异均无统计学意义(t=0.216~0.495,均 P > 0.05),Spexin 高、低表达组的 BMI 水平差异具有统计学意义,并且 Spexin 高表达组的 BMI 显著高于 Spexin 低表达组 (t=5.913,P < 0.05)。Spearman 相关性检验分析结果显示血清 Spexin 水平与 BMI 呈正相关关系 (rs值为 0.074,P < 0.05)。结论 Spexin 在 PCOS 中高表达并且其受 BMI 的影响。

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备注/Memo

备注/Memo:
作者简介:宋秀英(1983-),女,本科,主治医师,研究方向:女性生殖器官疾病的病因、病理、诊断及防治,E-mail:gaoxinsongxiuy@163.com。
通讯作者:赵莉(1977-),女,大专,主治医师,研究方向,女性生殖器官疾病的病因、病理、诊断及防治,E-mail:83964606@qq.com。
更新日期/Last Update: 1900-01-01