[1]李毓龙,朱紫衣,付　霞,等.血浆 S- 腺苷同型半胱氨酸水平检测与冠状动脉狭窄程度的关系研究[J].现代检验医学杂志,2021,36(03):92-96.[doi:10.3969/j.issn.1671-7414.2021.03.021]
　LI Yu-long,ZHU Zi-yi,FU Xia,et al.Study on the Relationship between Plasma S-adenosine Homocysteine Levels and Coronary Artery Stenosis[J].Journal of Modern Laboratory Medicine,2021,36(03):92-96.[doi:10.3969/j.issn.1671-7414.2021.03.021]
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血浆 S- 腺苷同型半胱氨酸水平检测与冠状动脉狭窄程度的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
92-96
栏目:
论　著
出版日期:
2021-05-31

文章信息/Info

Title:
Study on the Relationship between Plasma S-adenosine Homocysteine Levels and Coronary Artery Stenosis
文章编号:
1671-7414（2021）03-092-05
作者:
李毓龙; 朱紫衣; 付　霞; 等
（简阳市人民医院实验医学科，四川简阳 641400）
Author(s):
LI Yu-long;  ZHU Zi-yi;  FU Xia;  YU Jian-bo;  ZHONG Yuan-sheng
（Department of Laboratory Medicine, Jianyang Municipal People’s Hospital, Sichuan Jianyang 641400, China）
关键词:
S- 腺苷同型半胱氨酸 ;  冠状动脉粥样硬化性心脏病 ; Gensini 评分 ;  相关性
分类号:
R543.3；R446.112
DOI:
10.3969/j.issn.1671-7414.2021.03.021
文献标志码:
A
摘要:
目的 探讨血浆中 S- 腺苷同型半胱氨酸（S-adenosine homocysteine，SAH）与冠状动脉狭窄程度的关系。方法　选取 2018 年 1 月 ~2019 年 12 月于简阳市人民医院就诊的疑似冠状动脉粥样硬化性心脏病（coronary atherosclerotic heartdisease,CHD）患者 663 例作为研究对象，根据冠状动脉造影检查结果，将患者分为 CHD 组（经冠状动脉造影确诊）(n=386) 和对照组（n=277）。采集空腹静脉血标本检测血清总胆固醇（total cholesterol,TC）、三酰甘油（triglyceride,TG)、低密度脂蛋白胆固醇（low density lipoprotein cholesterol,LDL-C）、高密度脂蛋白胆固醇（high density lipoproteincholesterol,HDL-C）、脂蛋白 (a)[Lipoprotein a，LP(a)]、同型半胱氨酸（homocysteine,Hcy）和 SAH 水平，采用 Gensini积分法评估 CHD 组冠状动脉狭窄程度，并分析上述指标与其相关性。结果 CHD 组患者 LDL-C，LP(a)，Hcy 和 SAH水平高于对照组 , 而 HDL-C 水平低于对照组，差异均具有统计学意义（t=3.71~14.70, 均 P ＜ 0.05）；CHD 组患者冠状动脉狭窄程度 Genisini 积分与患者 LDL-C，LP(a)，Hcy 和 SAH 呈正相关（r=0.408~0.635, 均 P ＜ 0.05），而与 HDL-C呈负相关（r=-0.404，P ＜ 0.05）。结论 CHD 患者血浆 SAH 水平明显升高，与传统血清学指标相比，血浆 SAH 浓度水平与冠状动脉病变程度的相关性最高，血浆 SAH 可能是一种新的生物学标志物用于 CHD 的临床诊断，在临床诊疗过程中可将血浆 SAH 用于评估冠脉病变情况，对于 CHD 的预防和诊疗具有重要意义。

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备注/Memo

备注/Memo:
作者简介：李毓龙（1991-），男，本科，主管检验师，研究方向：临床生化检验与疾病发生发展关系研究，E-mail：kl734714158@126.com。
更新日期/Last Update: 1900-01-01