[1]段金利.原发性高血压并发肾病患者尿微量清蛋白 / 尿肌酐比值与心率变异性的相关性研究[J].现代检验医学杂志,2021,36(03):122-127.[doi:10.3969/j.issn.1671-7414.2021.03.028]
　DUAN Jin-li.Study on the Correlation between Heart Rate Variability and UrinaryMicroalbumin/Urinary Creatinine Ratio in Patients with EssentialHypertension and Kidney Disease[J].Journal of Modern Laboratory Medicine,2021,36(03):122-127.[doi:10.3969/j.issn.1671-7414.2021.03.028]
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原发性高血压并发肾病患者尿微量清蛋白 / 尿肌酐比值与心率变异性的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
122-127
栏目:
检验与临床
出版日期:
2021-05-31

文章信息/Info

Title:
Study on the Correlation between Heart Rate Variability and UrinaryMicroalbumin/Urinary Creatinine Ratio in Patients with EssentialHypertension and Kidney Disease
文章编号:
1671-7414（2021）03-122-06
作者:
段金利
(重庆市长寿区中医院检验科，重庆　401220)
Author(s):
DUAN Jin-li
(Department of Clinical Laboratory，Changshou District Hospital of Traditional Chinese Medicine,Chongqing 401220,China)
关键词:
尿微量清蛋白; 尿肌酐; 尿清蛋白 / 尿肌酐比值; 原发性高血压; 肾病; 心率变异性
分类号:
R544.11；R446.112
DOI:
10.3969/j.issn.1671-7414.2021.03.028
文献标志码:
A
摘要:
目的　探讨原发性高血压并发肾病患者心率变异性与尿微量清蛋白 / 尿肌酐比值（UACR）的相关性，分析UACR，心率变异性参数在原发性高血压肾功能损害的诊断价值。方法　选择重庆市长寿区中医院 2017 年 2 月 ~2019年 6 月收治的 106 例原发性高血压患者，根据是否并发肾病将其分为原发性高血压组（57 例）和并发肾病组（49 例），另选择 50 例健康志愿者为对照组。均检测 UACR，行动态心电图检测，记录心率变异性参数 [ 总体标准差 (SDNN) ，均值标准差 (SDANN) ，差值均方根（rrMSSD），差值 >50ms 百分比 (PNN50)，低频功率 (LF)，高频功率（HF）和 LF/HF]。Pearson 相关性分析 UACR 与心率变异性参数的相关性。受试者工作特征曲线（ROC）分析 UACR，心率变异性参数诊断原发性高血压并发肾病的价值。结果 SDNN，LF 和 LF/HF 在对照组、原发性高血压组、并发肾病组依次降低（F=37.420，17.342 和 23.616，均 P ＜ 0.05），UACR 依次升高（F=78.609，P ＜ 0.05），各组间差异显著（t=9.265~16.352，P 均＜ 0.05），SDANN，rMSSD，PNN50 和 HF 在各组间差异无统计学意义（F=0.017，0.175 和 0.078，0.471，均 P ＞0.05）。并发肾病组 UACR 与 SDNN，LF 和 LF/HF 呈负相关（r = -0.513、- 0.538 和 - 0.612，均 P ＜ 0.05），与SDANN，rMSSD，PNN50 和 HF 无关（r=0.115，0.171，0.182 和 0.162，均 P ＞ 0.05）。ROC 分析结果显示 UACR，SDNN，LF，LF/HF联合 UACR，SDNN，LF 与 LF/HF（以下简称联合诊断）诊断原发性高血压并发肾病的曲线下面积（AUC）分别为 0.731，0.749，0.683，0.772 和 0.885，联合诊断高于单独 UACR，SDNN，LF 和 LF/HF 诊断价值（Z=2.156，2.035，3.021 和2.013，均 P ＜ 0.05）。结论 UACR 与原发性高血压并发肾病患者心率变异性参数 SDNN，LF 和 LF/HF 存在显著相关性，UACR，SDNN，LF 和 LF/HF 可用作预测原发性高血压患者肾功能损伤的敏感指标。

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备注/Memo

备注/Memo:
作者简介：段金利 (1987-)，女，本科，主管检验师，研究方向：生化检验，E-mail：lhj6864@163.com。
更新日期/Last Update: 1900-01-01