[1]何 跃,梁 晶,文礼红,等.前列腺癌患者血清IL-17和IL-35水平表达与临床病理特征以及预后的关系研究[J].现代检验医学杂志,2021,36(04):96-100.[doi:10.3969/j.issn.1671-7414.2021.04.020]
 HE Yue,LIANG Jing,WEN Li-hong,et al.Study on the Relationship between Serum IL-17, IL-35 Levels andClinicopathological Features and Prognosis in Patients with Prostate Cancer[J].Journal of Modern Laboratory Medicine,2021,36(04):96-100.[doi:10.3969/j.issn.1671-7414.2021.04.020]
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前列腺癌患者血清IL-17和IL-35水平表达与临床病理特征以及预后的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
96-100
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Study on the Relationship between Serum IL-17, IL-35 Levels andClinicopathological Features and Prognosis in Patients with Prostate Cancer
文章编号:
1671-7414(2021)04-096-05
作者:
何 跃1梁 晶2文礼红1刘 宏1余文洪1孙 祯1
(1. 重庆北部宽仁医院泌尿疾病科, 重庆 401120; 2. 解放军联勤保障部队第九四零医院泌尿外科,兰州 730000)
Author(s):
HE Yue1 LIANG Jing2 WEN Li-hong1 LIU Hong1 YU Wen-hong1 SUN Zhen1
(1.Department of Urology,North Chongqing Kuanren Hospital, Chongqing 401120,China;2.Department of Urology,No. 940 Hospital of the Joint Logistics Support Force of the People’s Liberation Army, Lanzhou 730000,China)
关键词:
白细胞介素-17白细胞介素-35前列腺癌临床特征预后
分类号:
R737.25;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.04.020
文献标志码:
A
摘要:
目的 探讨血清白介素-17(IL-17)、白介素-35(IL-35)与前列腺癌(prostate cancer,PC)临床特征以及预后的关系。方法 选择2016 年3 月~2017 年6 月重庆北部宽仁医院和解放军联勤保障部队第九四零医院泌尿科收治的86 例前列腺癌患者(前列腺癌组)和60 例前列腺良性增生患者(对照组)。所有受试者检测血清IL-17 和IL-35 水平,比较不同临床特征患者血清IL-17 和IL-35 水平差异。Kaplan-Meier 生存分析不同血清IL-17,IL-35 水平前列腺癌患者无生化复发生存率和总生存率差异,Cox 回归分析影响前列腺患者预后的因素。结果 前列腺癌组血清IL-17,IL-35 水平(65.23±14.46pg/ml,132.15±23.65pg/ml)高于对照组(25.12±7.49pg/ml,61.42±10.58pg/ml),差异有统计学意义(t=19.707,21.684,均P < 0.001)。肿瘤分期pT3a,组织学分级Gleason 3-5 级,淋巴结转移和术前PSA ≥ 10 ng/ml 患者血清IL-17,IL-35水平高于肿瘤分期pT1-2,组织学分级Gleason 1-2 级,未发生淋巴结转移,术前PSA < 10ng/ml 患者,差异均有统计学意义(t=18.465,24.656,10.057,13.086;21.474,57.937,11.433,14.650,均P < 0.001)。Kaplan-Meier 生存曲线分析结果显示高血清IL-17 水平组,高血清IL-35 水平组无生化复发生存率,总生存率低于低血清IL-17 水平组,低血清IL-35水平组(Log-Rank χ2=7.031,4.701;7.832,5.483,均P < 0.05)。Cox 风险比例回归分析结果显示Gleason 3~5 级、淋巴结转移、高水平IL-17,IL-35 是前列腺癌患者不良预后的危险因素(P < 0.01)。结论 前列腺癌患者血清IL-17,IL-35水平明显升高,IL-17,IL-35 与前列腺癌的发生、发展和预后密切相关。

参考文献/References:

[1] WANG Guocan, ZHAO Di, SPRING D J,et al.Geneticsand biology of prostate cancer[J].GenesDev,2018,32(17/18):1105-1140.
[2] 高瑞松, 周青, 张晓波, 等. 湖南部分地区2877 例前列腺癌患者临床流行病学特征及流行学趋势分析[J]. 中华男科学杂志,2020,26(4):309-315.GAO Ruisong, ZHOU Qing, ZHANG Xiaobo, et al.Clinical features and epidemiological trend of prostatecancer in the Changsha area of Hunan Province: Analysisof 2 877 cases[J].National Journal of Andrology,2020,26(4):309-315.
[3] 苏欢, 陈明. 炎症反应与肿瘤微环境对前列腺癌作用机制的研究进展[J]. 东南大学学报( 医学版),2017,36(5):847-851.SU Huan, CHEN Ming. Research progress on themechanism of inflammatory response and tumormicroenvironment on prostate cancer[J].J SoutheastUniv(Med Sci Edi), 2017,36(5):847-851.
[4] MCGEACHY M J,CUA D J, GAFFEN S L.The IL-17family of cytokines in health and disease[J]. Immunity.2019,50(4):892-906.
[5] WANG Ke, LIU Jiaming, LI Jiansheng. IL-35-producing B cells in gastric cancer patients. Medicine(Baltimore). 2018,97(19):e0710.
[6] PLOUSSARD G, STAERMAN F, PIER-REVELCINJ, et al. Predictive factors of oncologic outcomes inpatients who do not achieve undetectable prostatespecific antigen after radical prostatectomy[J]. TheJournal of urology, 2013, 190(5);1750-1756.
[7] SINGH N, BABY D,RAJGURU J P, et al.Inflammationand cancer[J].Ann Afr Med,2019,18(3):121-126.
[8] YANG Keqin, LIU Yan, HUANG Qinghua, et al. Bonemarrow-derived mesenchymal stem cells inducedby inflammatory cytokines produce angiogeneticfactors and promote prostate cancer growth[J].BMCCancer,2017,17(1):878.
[9] CHEN Dandan,TANG Ping, LIU Linxiang, et al. Bonemarrow-derived mesenchymal stem cells promote cellproliferation of multiple myeloma through inhibitingT cell immune responses via PD-1/PD-L1 pathway[J].Cell Cycle,2018,17(7):858-867.
[10] PORTER C M, SHRESTHA E,PEIFFER L B,et al.Themicrobiome in prostate inflammation and prostatecancer[J].Prostate Cancer Prostatic Dis,2018,21(3):345-354.
[11] RICH H E, ALCORN J F.IL-17 strikes a chord inchronic obstructive pulmonary disease exacerbation[J].Am J Respir Cell Mol Biol,2018,58(6):669-670.
[12] SONG Yang, YANG Jianming. Role of interleukin(IL)-17 and T-helper (Th)17 cells in cancer[J].BiochemBiophys Res Commun,2017,493(1):1-8.
[13] 徐锐, 王莉, 李满祥. 白细胞介素-17 在前列腺癌组织中的表达及临床意义[J]. 宁夏医科大学学报,2017,39(7):756-759.XU Rui,WANG Li, LI Manxiang. Expression andclinical significance of interleukin-17 in prostatticcancer[J].Journal of Ningxia Medical University,2017,39(7):756-759.
[14] WANG Xun, YANG Lingyun, HUANG Feng, et al.Inflammatory cytokines IL-17 and TNF-α up-regulatePD-L1 expression in human prostate and colon cancercells[J].Immunol Lett,2017,184:7-14.
[15] GUO Na, SHEN Ge, ZHANG Ying,et al. Interleukin-17promotes migration and invasion of human cancer cellsthrough upregulation of MTA1 Expression[J].FrontOncol,2019,9:546.
[16] CHEN Chong, ZHANG Qiuyang, LIU Sen, et al. IL-17 and insulin/IGF1 enhance adhesion of prostatecancer cells to vascular endothelial cells through CD44-VCAM-1 interaction[J].Prostate,2015,75(8):883-895.
[17] TEYMOURI M,PIRRO M,FALLARINO F,et al.IL-35,a hallmark of immune-regulation in cancer progression,chronic infections and inflammatory diseases[J].Int JCancer,2018,143(9):2105-2115.
[18] FRIEDMAN A, LIAO K L.The role of the cytokinesIL-27 and IL-35 in cancer[J].Math Biosci Eng,2015,12(6):1203-1217.
[19] LEE C C, LIN J C, HWANG W L,et al.Macrophagesecretedinterleukin-35 regulates cancer cellplasticity to facilitate metastatic colonization[J].NatCommun,2018,9(1):3763.
[20] ZHANG Jian, MAO Tao, WANG Shuyun, et al. Interleukin-35 expression is associated with colon cancerprogression[J].Oncotarget,2017,8(42):71563-71573.
[21] ZHU Jialin, YANG Xueling, WANG Yan, et al.Interleukin-35 is associated with the tumorigenesis and progressionof prostate cancer[J].Oncol Lett,2019,17(6):5094-5102.
[22] OLSON B M, JANKOWSKA-GAN E, BECKER J T,etal. Human prostate tumor antigen-specific CD8+ regulatoryT cells are inhibited by CTLA-4 or IL-35 blockade[J].J Immunol,2012,189(12):5590-601.

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备注/Memo

备注/Memo:
作者简介:何跃(1983-),男,博士研究生,主治医师,研究方向:移植免疫耐受及肿瘤免疫,E-mail:heyuec198300@163.com。
通讯作者:余文洪(1981-),男,硕士,副主任医师,研究方向:自身免疫性疾病,E-mail:yuwh198122@163.com。
更新日期/Last Update: 1900-01-01