[1]陈丽媛.原发性高血压患者血清Ficolin-3,CysC和Hcy水平与颈动脉内膜中层厚度的相关性分析[J].现代检验医学杂志,2021,36(04):139-141.[doi:10.3969/j.issn.1671-7414.2021.04.030]
 CHEN Li-yuan.Analysis on the Correlation between Serum Ficolin 3, Cys C and Hcy Levelsand Carotid Intima-Media Thickness in Patients with Essential Hypertension[J].Journal of Modern Laboratory Medicine,2021,36(04):139-141.[doi:10.3969/j.issn.1671-7414.2021.04.030]
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原发性高血压患者血清Ficolin-3,CysC和Hcy水平与颈动脉内膜中层厚度的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
139-141
栏目:
检验与临床
出版日期:
2021-07-31

文章信息/Info

Title:
Analysis on the Correlation between Serum Ficolin 3, Cys C and Hcy Levelsand Carotid Intima-Media Thickness in Patients with Essential Hypertension
文章编号:
1671-7414(2021)04-139-04
作者:
陈丽媛
(河南科技大学第一附属医院中心实验室,河南洛阳 471003)
Author(s):
CHEN Li-yuan
(Department of Central Laboratory, the First Affiliated Hospital of Henan Science and TechnologyUniversity, Henan Luoyang 471003, China)
关键词:
原发性高血压颈动脉内膜中层厚度纤维胶凝蛋白3胱抑素C同型半胱氨酸
分类号:
R544.11;R446.112
DOI:
10.3969/j.issn.1671-7414.2021.04.030
文献标志码:
A
摘要:
目的 观察原发性高血压(essential hypertension,EH)患者血清纤维胶凝蛋白3(ficolin 3,FCN3)、胱抑素C(cystatin C,Cys C)、同型半胱氨酸(homocysteine,Hcy)水平与颈动脉内膜中层厚度(intima-mediathickness,IMT)的相关性,以此为临床诊断、治疗提供参考依据。方法 回顾性分析2018 年1 月~2019 年12 月于河南科技大学第一附属医院接受治疗的80 例EH 患者临床资料,根据彩色多普勒超声检测的IMT 结果将38 例IMT < 1.0mm 的患者作为正常组,将42 例IMT ≥ 1.0mm 患者作为异常组。比较两组患者血清FCN3,Cys C 和Hcy 水平,并分析血清FCN3,Cys C 和Hcy 水平与患者IMT 的相关性。结果 异常组患者血清FCN3 水平低于正常组,差异有统计学意义(t=5.930,P < 0.05);异常组患者血清Cys C 和Hcy 水平高于正常组,差异有统计学意义(t=12.469,33.204,均P < 0.05);相关性分析发现,EH 患者的血清FCN3 水平与IMT 呈负相关(r=-0.433,P < 0.05),血清Cys C,Hcy 水平与IMT呈正相关(r=0.825,0.887,均P < 0.05)。结论 EH 患者血清FCN3,Cys C 和Hcy 水平与IMT 密切相关,FCN3 低表达,Cys C 和Hcy 高表达提示了EH 患者存在心血管疾病的风险,可将其纳入对EH 心脑血管疾病发生风险的评估及防治中来。

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备注/Memo

备注/Memo:
作者简介:陈丽媛(1984-),女,硕士研究生,主管技师,研究方向:医学检验,E-mail:skrpr00qill20@163.com。
更新日期/Last Update: 1900-01-01