[1]胡　艺,何熙国,周琮凯.血清sFlt-1，PTX-3，D-二聚体水平对ERCP术后胰腺炎严重程度的相关性及预测价值研究[J].现代检验医学杂志,2021,36(04):142-146.[doi:10.3969/j.issn.1671-7414.2021.04.031]
　HU Yi,HE Xi-guo,ZHOU Cong-kai.Study on the Correlation and Predictive Value of Serum sFlt-1, PTX-3,D-dimer Levels and the Severity of Post-ERCP Pancreatitis[J].Journal of Modern Laboratory Medicine,2021,36(04):142-146.[doi:10.3969/j.issn.1671-7414.2021.04.031]
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血清sFlt-1，PTX-3，D-二聚体水平对ERCP术后胰腺炎严重程度的相关性及预测价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
142-146
栏目:
检验与临床
出版日期:
2021-07-31

文章信息/Info

Title:
Study on the Correlation and Predictive Value of Serum sFlt-1, PTX-3,D-dimer Levels and the Severity of Post-ERCP Pancreatitis
文章编号:
1671-7414（2021）04-142-05
作者:
胡　艺; 何熙国; 周琮凯
（江油市人民医院消化内科，四川江油 621700）
Author(s):
HU Yi;  HE Xi-guo;  ZHOU Cong-kai
（Department of Gastroenterology, Jiangyou People’s Hospital，Sichuan Jiangyou 621700，China）
关键词:
经内镜逆行胰胆管造影术; 胰腺炎; 可溶性Fms 样酪氨酸激酶-1; 穿透素3; D- 二聚体
分类号:
R576；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.031
文献标志码:
A
摘要:
目的　探讨血清可溶性Fms 样酪氨酸激酶-1(soluble FMs-like tyrosine kinase-1，sFlt-1)、穿透素3(pentraxin-3，PTX-3)、D- 二聚体(D-dimer，D-D) 与ERCP 术后胰腺炎(post-ERCP pancreatitis，PEP) 严重程度的相关性及预测价值。方法　选取江油市人民医院消化内科(2018 年1 月～ 2020 年1 月) 收治的150 例行经内镜逆行胰胆管造影术(endoscopicretrograde cholangiopancreatography，ERCP) 治疗的胆管结石患者，根据术后48h 内是否发生PEP 分为PEP 组(n=42)和NPEP 组(n=108) 例，并根据修订版亚特兰大分类标准(revised atlanta classification standard，RACS) 将PEP 患者分为SAP 组(n=12)、MSAP 组(n=11) 和MAP 组(n=19)。对比各组血清淀粉酶(amylase，AMY)，sFlt-1，PTX-3 和D-D水平，点二列相关系数分析PEP 患者血清sFlt-1 和PTX-3，D-D 水平与RACS 分级的相关性，ROC 曲线分析血清sFlt-1，PTX-3 和D-D 水平对PEP 的预测价值。结果　PEP 组血清AMY，sFlt-1，PTX-3 和D-D 水平明显高于NPEP 组，差异均有统计学意义（t=51.591，5.429，25.301 和35.040，均P ＜ 0.05）；不同严重程度PEP 患者血清AMY，sFlt-1，PTX-3 和D-D 水平随着病情严重程度增加而提升，差异均有统计学意义(F=63.482，62.125，45.218 和70.612，均P＜ 0.05)；ROC 曲线显示，血清sFlt-1+PTX-3+D-D 预测PEP 的AUC 明显大于各指标单独及两两联合预测，敏感度、特异度、准确度也更高。结论　PEC 患者血清sFlt-1，PTX-3，D-D 水平明显提升，与病情严重程度密切相关，联合检测有助于PEP 诊断。

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备注/Memo

备注/Memo:
作者简介：胡艺（1984-），男，本科，主治医师，从事消化内科研究工作，E-mail：shenli066@126.com。
更新日期/Last Update: 1900-01-01