[1]宋婷阁,张鹏举,耿　彪,等.新生儿急性呼吸窘迫综合征患者血清miR-183-5p的表达及与IL-1β，IL-6和TNF-α水平的相关性[J].现代检验医学杂志,2021,36(05):55-57.[doi:10.3969/j.issn.1671-7414.2021.05.012]
　SONG Ting-ge,ZHANG Peng-ju,GENG Biao,et al.Expression of Serum miR-183-5p in Patients with Neonatal Acute RespiratoryDistress Syndrome and Its Correlation with IL-1 β, IL-6 and TNF-α[J].Journal of Modern Laboratory Medicine,2021,36(05):55-57.[doi:10.3969/j.issn.1671-7414.2021.05.012]
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新生儿急性呼吸窘迫综合征患者血清miR-183-5p的表达及与IL-1β，IL-6和TNF-α水平的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年05期
页码:
55-57
栏目:
论　著
出版日期:
2021-10-14

文章信息/Info

Title:
Expression of Serum miR-183-5p in Patients with Neonatal Acute RespiratoryDistress Syndrome and Its Correlation with IL-1 β, IL-6 and TNF-α
文章编号:
1671-7414（2021）05-055-04
作者:
宋婷阁; 张鹏举; 耿　彪; 等
（保定市第二中心医院检验科，河北涿州 072750）
Author(s):
SONG Ting-ge;  ZHANG Peng-ju;  GENG Biao;  YAO Wei-li
（Department of Clinical Laboratory，the Second Central Hospital of Baoding，Hebei Zhuozhou 072750，China）
关键词:
急性呼吸窘迫综合征; 新生儿; miR-183-5p; 白细胞介素-1β; 白细胞介素-6; 肿瘤坏死因子-α
分类号:
R722.12；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.05.012
文献标志码:
A
摘要:
目的　探讨新生儿急性呼吸窘迫综合征（acute respiratory distress syndrome, ARDS）患者血清miR-183-5p的表达及其与白细胞介素-1β(IL-1β)、白细胞介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）的相关性。方法　选取保定市第二中心医院收治的87例ARDS新生儿为研究对象。根据ARDS患儿出院时生存情况分为生存组（n=68）和死亡组（n=24），按照新生儿危重评分结果分为非危重组（n=53，>90 分）、危重组（n=24, 70～90 分）、极危重组（n=15, <70 分），比较各组血清miR-183-5p，IL-1β，IL-6及TNF-α水平差异。ARDS患儿miR-183-5p与IL-1β，IL-6及TNF-α的相关性采用Pearson相关分析。结果　与生存组比较，死亡组血清miR-183-5p（2.15±0.94 vs 0.96±0.38），IL-1β（168.20±30.62 vs 110.25±19.30，pg/mL），IL-6（217.28±44.27 vs 151.30±32.46，pg/mL）及TNF-α（81.16±19.24 vs 48.27±14.30，pg/mL）水平均明显升高（P<0.001）。随着病情加重ARDS患儿血清miR-183-5p，IL-1β，IL-6及TNF-α水平逐渐升高，极危重组>危重组>非危重组（P<0.001）。相关分析显示，ARDS患儿血清miR-183-5p表达水平与IL-1β，IL-6及TNF-α均呈正相关（P<0.001）。结论　ARDS患儿血清miR-183-5p高表达与IL-1β，IL-6，TNF-α水平及病情严重程度相关，可能是预测ARDS患儿病情严重程度的生物学指标。
Abstract:
Objective　To investigate the expression of serum miR-183-5p in patients with neonatal acute respiratory distresssyndrome (ARDS) and its correlation with interleukin-1 β (IL-1 β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).Methods　The 87 newborns with ARDS admitted to the Second Central Hospital of Baoding City were selected as the researchobjects. According to the survival status of ARDS children, they were divided into survival group (n=68) and death group (n=24).According to NCIS score, they were divided into non critical group (n=53, > 90 score), critical group (n=24, 70~90 score), andextremely critical group (n=15, <70 score). The serum levels of miR-183-5p, IL-1β, IL-6 and TNF-α were compared in eachgroup. Pearson correlation analysis were used to analyze the correlation between miR-183-5p and IL-1β, IL-6 and TNF-α inchildren with ARDS. Results　Compared with the survival group,the serum levels of miR-183-5p (2.15±0.94 vs 0.96±0.38),IL-1β (168.20±30.62pg/ml vs 110.25±19.30pg/ml), IL-6 (217.28±44.27pg/ml vs 151.30±32.46 pg/ml) and TNF-α(81.16±19.24pg/ml vs 48.27±14.30 pg/ml) were significantly increased in the death group (P<0.001). The levels of serum miR-183-5p, IL-1 β, IL-6 and TNF-α increased gradually with the aggravation of ARDS, and the most dangerous recombinant >dangerous recombinant > non dangerous recombinant (P< 0.001). Correlation analysis showed that serum miR-183-5p expressionlevel were positively correlated with IL-1β, IL-6 and TNF-α in ARDS children (P<0.001). Conclusion　The high expressionof serum miR-183-5p in children with ARDS were related to the levels of IL-1 β, IL-6, TNF-α and the severity of the disease,which may be a biological indicator to predict the severity of the disease in children with ARDS.

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备注/Memo

备注/Memo:
作者简介：宋婷阁（1983-）, 女，本科，主管检验师，主要从事临床检验诊断研究,E-mail: stg43665391@163.com。
更新日期/Last Update: 1900-01-01