[1]利荣乔.血清Galectin-3和HDL-C水平检测对急性缺血性脑卒中预后的影响研究[J].现代检验医学杂志,2021,36(05):128-132.[doi:10.3969/j.issn.1671-7414.2021.05.029]
　LI Rong-qiao.Effect of Serum Galectin-3 and HDL-C Levels on Prognosis of AcuteIschemic Stroke[J].Journal of Modern Laboratory Medicine,2021,36(05):128-132.[doi:10.3969/j.issn.1671-7414.2021.05.029]
点击复制

血清Galectin-3和HDL-C水平检测对急性缺血性脑卒中预后的影响研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年05期
页码:
128-132
栏目:
检验与临床
出版日期:
2021-10-14

文章信息/Info

Title:
Effect of Serum Galectin-3 and HDL-C Levels on Prognosis of AcuteIschemic Stroke
文章编号:
1671-7414（2021）05-128-06
作者:
利荣乔
（广西壮族自治区江滨医院，南宁 530021）
Author(s):
LI Rong-qiao
（Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China）
关键词:
半乳糖蛋白-3; 高密度脂蛋白胆固醇; 缺血性脑卒中
分类号:
R743.3；R446.112
DOI:
10.3969/j.issn.1671-7414.2021.05.029
文献标志码:
A
摘要:
目的　探讨血清半乳糖蛋白-3（Galectin-3）和高密度脂蛋白胆固醇（high density lipoprotein cholesterol, HDL-C）浓度对急性缺血性脑卒中（acute ischemic stroke,AIS）预后的影响。方法　选择2014年1月～2019年6月广西壮族自治区江滨医院诊治的AIS患者1 104例进行前瞻性研究，按Galectin-3（<8.65ng/ml和≥8.65ng/ml）和HDL-C（<0.9mmol/L和≥0.9mmol/L）水平将其分为低Galectin-3/高HDL-C组，低Galectin-3/低HDL-C组，高Galectin-3/高HDL-C组和高Galectin-3/低HDL-C组，采用Kaplan-Meier及Cox风险模型分析Galectin-3/HDL-C水平对AIS患者随访6~12个月预后结局（心血管事件和死亡复合结局、复发性脑卒中、心血管事件、死亡），采用受试者工作特征曲线（receiver operating characteristic curve, ROC）分析Galectin-3/HDL-C水平对AIS患者心血管事件和死亡复合结局的预测价值。结果　1 104例患者中，失访36人，共1 068例患者入组，与低Galectin-3/高HDL-C组相比，高Galectin-3/低HDL-C组随访6~12个月内发生心血管事件和死亡的复合结局、复发性脑卒中、心血管事件的HR（95%CI）分别为1.56(1.08~2.22)，1.84(1.10~2.98)，1.95(1.26~2.98)和1.35(0.85~2.15)，主要结局和次要结局的发生率明显升高（均P<0.05）；Kaplan-Meier曲线示与低Galectin-3/高HDL-C组相比，高Galectin-3/低HDL-C组发生心血管事件和死亡复合结局发生率高（Log rank检验，χ2=4.189，P<0.001）；ROC曲线示Galectin-3和HDL-C对缺血性脑卒中患者不良预后具有预测价值（χ2=3.85，P=0.002）。结论　基线血清高Galectin-3/低HDL-C水平组与缺血性脑卒中后6~12个月内发生不良结局相关，对卒中不良预后具有预测价值。
Abstract:
Objective　To investigate the effects of serum Galectin-3 and high-density lipoprotein cholesterol (HDL-C)concentrations on the prognosis of acute ischemic stroke (AIS). Methods　A prospective study was conducted on 1 104 patientswith AIS treated in Jiangbin Hospital of Guangxi Zhuang Autonomous Region from January 2014 to June 2019. According toGalectin-3 (<8.65ng/ml and ≥ 8.65ng/ml) and HDL-C (<0.9mmol/L and ≥ 0.9mmol/L) levels could be divided into four groups(low Galectin-3/ high HDL-C, low Galectin-3/low HDL-C, high Galectin-3/high HDL-C and high Galectin-3/low HDL-C).Kakathr-Meier and Cox risk model were used to analyze the prognosis of Galectin-3 /HDL-C level in AIS patients followed upfor 6~12 months (compound outcome of cardiovascular events and death, recurrent stroke, cardiovascular events and death), andthe receiver operating Characteristic curve (ROC) was used to analyze the predictive value of Galectin-3/HDL-C level in complexoutcome of cardiovascular events and death in AIS patients. Results　Of 1 104 patients, 36 were lost to follow-up, a total of1 068 were enrolled. Compared with the low Galectin-3/ high HDL-C group, the combined outcome of cardiovascular events anddeath, recurrent stroke, and cardiovascular events [HR (95%CI)] in the high Galectin-3/ low HDL-C group were 1.56(1.08~2.22),1.84(1.10~2.98), 1.95(1.26~2.98) and 1.35(0.85~2.15) during 6~12 months of follow-up, respectively. The incidence of primaryand secondary outcomes was significantly higher in the high Galectin-3/ low HDL-C group (all P<0.05). Kaplan-Meier curveshowed a high incidence of cardiovascular events and death composite outcomes in the high Galectin-3/ low HDL-C group thanin the low Galectin-3/ high HDL-C group (Log rank test, χ2=4.189, P<0.001). ROC curve showed that Galectin-3 and HDL-Chad predictive value for poor prognosis of patients with ischemic stroke(χ2=3.85, P=0.002). Conclusion　Baseline serum highGalectin-3/ low HDL-C levels were associated with adverse outcomes within 6~12 months after ischemic stroke, which haspredictive value for poor prognosis of stroke.

参考文献/References:

[1] 卢克红，潘旭东，马爱军，等．半乳糖凝集素-3 与脑动脉粥样硬化广泛程度及大动脉粥样硬化型脑卒中预后的关系[J]. 中华神经科杂志,2016,49(7):531-535.LU Kehong, PAN Xudong, MA Aijun, et al.Relationship between galectin-3 and the severity ofcerebral artery atherosclerosis and the prognosis ofpatients with large artery atherosclerotic stroke [J].Chinese Journal of Neurology, 2016,49 (7): 531-535.
[2] 葛冰磊，俞善春，金纪伟．急性缺血性脑卒中患者血清Hcy, GAL3, MCP-1 表达及其临床意义[J]. 中国医师杂志,2019,21(6):893-897.GE Binglei, YU Shanchun, JIN Jiwei. Expression ofserum Hcy, GAL3 and MCP-1 in patients with acuteischemic stroke and its clinical significance [J]. Journalof Chinese Physician, 2019,21 (6): 893-897.
[3] ZENG Nimei, WANG Aili, XU Tan, et al. Co-effectof serum Galectin-3 and high-density lipoproteincholesterol on the prognosis of acute ischemic stroke[J].Journal of Stroke & Cerebrovascular Diseases, 2019,28(7):1879-1885.
[4] VENKATRAMAN A, HARDAS S, PATEL N, etal. Galectin-3: an emerging biomarker in stroke andcerebrovascular diseases[J].European Journal ofNeurology, 2018, 25(2): 238-246.
[5] WANG Aili, ZHONG Chongke, ZHU Zhengbao,et al. Serum Galectin-3 and poor outcomes amongpatients with acute ischemic stroke[J]. STROKE, 2018,49(1):211-214.
[6] MARTINEZ-AGUILAR E, ORBE J, FERN?NDEZMONTEROA, et al. Reduced high-density lipoproteincholesterol: A valuable, Independent prognostic markerin peripheral arterial disease[J]. Journal of VascularSurgery, 2017, 66(5): 1527-1533,e1.
[7] TZIOMALO S K,KATRI N I K,PAPAGIANNIM, et al. Impaired antioxidative activity of highdensitylipoprotein is associated with more severeacute ischemic stroke.[J]. Metabolism: Clinical andExperimental, 2019, 98:49-52.
[8] ZENG Nimei, WANG Aili, ZHONG Chongke, et al.Association of serum Galectin-3 with risks of deathand vascular events in acute ischaemic stroke patients:the role of hyperglycemia[J]. European Journal ofNeurology, 2019, 26(3): 415-421.
[9] ARORA P, AGARWAL Z, VENKATRAMAN A, et al.Galectin-3 and risk of ischaemic stroke: Reasons forgeographic and racial differences in stroke cohort[J].European Journal of Neurology, 2017, 24(12): 1464-1470.
[10] FRENCH B, WANG Le, KY B, et al. Prognostic valueof Galectin-3 for adverse outcomes in chronic heartfailure[J]. Journal of Cardiac Failure, 2016, 22(4): 256-262.
[11] YAN Xinjing, YU Guofeng, JIE Yuanqing, et al. Roleof Galectin-3 in plasma as a predictive biomarker ofoutcome after acute intracerebral hemorrhage(Article)[J].Journal of the Neurological Sciences, 2016,368:121-127.
[12] HARA A, NIWA M, NOGUCHI K, et al. Galectin-3 asa Next-Generation biomarker for detecting early stageof various diseases[J]. Biomolecules, 2020, 10(3): 389.
[13] HAN Dong,WANG Zhihao,ZHANG Na, et al. Serumgalectin-3 level,not galectin-1,is associated with theclinical feature and outcome in patients with acuteischemic stroke[J]. Oncotarget, 2017, 8(65):109752-109761.
[14] DENG Qiwen, LI Shuo, WANG Huan, et al. The shorttermprognostic value of the triglyceride-to-highdensitylipoprotein cholesterol ratio in acute ischemicstroke[J]. Aging and Disease, 2018, 9(3): 498-506.
[15] 李友凤，王春慧，孙文先，等．总胆固醇/ 高密度脂蛋白胆固醇比值对脑卒中复发的预测价值[J]. 中国实用神经疾病杂志, 2020,23 (9): 771-775.LI Youfeng, WANG Chunhui, SUN Wenxian, et al.Association of total cholesterol/high density lipoproteincholesterol ratio and stroke recurrence[J].ChineseJournal of Practical Nervous Diseases, 2020,23 (9):771-775.
[16] TZIOMALOS K, GIAMPATZIS V, BOUZIANA S D,et al. Prognostic significance of major lipids in patientswith acute ischemic stroke[J]. Metabolic Brain Disease,2017, 32(2): 395-400.
[17] 刘辉, 樊凡, 杨翠, 等. 单核细胞与高密度脂蛋白胆固醇比值与缺血性心脑血管病预后研究进展[J]．中华老年心脑血管病杂志,2020,22(3):332-334.LIU Hui, FAN Fan, YANG Cui, et al. The relationshipbetween the ratio of monocyte to high densitylipoprotein cholesterol and the prognosis of ischemiccardio cerebrovascular disease [J]. Chinese Journal ofGeriatric Heart Brain and Vessel Diseases, 2020,22 (3):332-334.
[18] CHRONI A, KARDASSIS D. HDL dysfunctioncaused by mutations in apoA-I and other genes that arecritical for HDL biogenesis and remodeling[J]. CurrentMedicinal Chemistry, 2019, 26(9): 1544-1575.
[19] CERVELLATI C, VIGNA G B, TRENTINI A, et al.Paraoxonase-1 activities in individuals with differentHDL circulating levels: Implication in reversecholesterol transport and early vascular damage[J].Atherosclerosis, 2019, 285: 64-70.

相似文献/References:

[1]闫　欣,商素亮,李　娜,等.血浆S1P和HDL-C表达水平与帕金森病患者临床症状的相关性研究[J].现代检验医学杂志,2022,37(03):182.[doi:10.3969/j.issn.1671-7414.2022.03.038]
　YAN Xin,SHANG Su-liang,LI Na,et al.Correlation between Plasma S1P, HDL-C Expressions Levels and Clinical Symptoms in Patients with Parkinson’s Disease[J].Journal of Modern Laboratory Medicine,2022,37(05):182.[doi:10.3969/j.issn.1671-7414.2022.03.038]
[2]赵 莹,欧阳雅帆,杨晓燕,等.高脂血症患者血清TC, TG 和HDL-C 水平与精液质量相关性研究[J].现代检验医学杂志,2022,37(04):174.[doi:10.3969/j.issn.1671-7414.2022.04.034]
　ZHAO Ying,OUYANG Ya-fan,YANG Xiao-yan,et al.Study on Correlation between the Level of Serum TC, TG and HDL-C and Semen Quality of Patients with Hyperlipidemia[J].Journal of Modern Laboratory Medicine,2022,37(05):174.[doi:10.3969/j.issn.1671-7414.2022.04.034]
[3]何建建a,李海婧a,王 彬b,等.中青年急性冠脉综合征患者TyG 指数、HCY 和HDL-C 表达水平及临床价值研究[J].现代检验医学杂志,2022,37(06):119.[doi:10.3969/j.issn.1671-7414.2022.06.022]
　HE Jian-jiana,LI Hai-jinga,WANG Binb,et al.Study on TyG Index, HCY and HDL-C Expression Levels and Clinical Value in Young and Middle-aged Patients with Acute Coronary Syndrome[J].Journal of Modern Laboratory Medicine,2022,37(05):119.[doi:10.3969/j.issn.1671-7414.2022.06.022]

备注/Memo

备注/Memo:
作者简介：利荣乔（1984-），男，本科，主管技师，研究方向：临床血液学检验、生化检验，E-mail：ganlang896760@163.com。
更新日期/Last Update: 1900-01-01