[1]张　鹏,迟　洁,白香妮,等.临床患者血清CK-MB活性大于总肌酸激酶活性的生物学特征及原因分析[J].现代检验医学杂志,2021,36(06):116-119.[doi:10.3969/j.issn.1671-7414.2021.06.024]
　ZHANG Peng,CHI Jie,BAI Xiang-ni,et al.Biological Characteristics and Cause Analysis of Clinical Patients with Serum CK-MB-to-Total-CK Ratio More Than 1.0[J].Journal of Modern Laboratory Medicine,2021,36(06):116-119.[doi:10.3969/j.issn.1671-7414.2021.06.024]
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临床患者血清CK-MB活性大于总肌酸激酶活性的生物学特征及原因分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年06期
页码:
116-119
栏目:
论　著
出版日期:
2021-12-15

文章信息/Info

Title:
Biological Characteristics and Cause Analysis of Clinical Patients with Serum CK-MB-to-Total-CK Ratio More Than 1.0
文章编号:
1671-7414（2021）06-116-04
作者:
张　鹏1; 迟　洁2; 白香妮3; 王银坤2; 郑　霄2; 刘文康2
（1.西安工会医院检验科，西安710100；2.陕西省人民医院检验科，西安 710068；3.西电集团医院，西安 710077）
Author(s):
ZHANG Peng;  CHI Jie;  BAI Xiang-ni;  et al
（1.Department of Clinical Laboratory, Xi’an Trade Union Hospital, Xi’an 710100, China；2.Department of Clinical Laboratory, Shaanxi Provincial People’s Hospital, Xi’an 710068, China；3.Department of Clinical Laboratory, Xi’an XD Group Hospital, Xi’an 710077，China）
关键词:
肌酸激酶活性（CK）; 肌酸激酶同工酶（CK-MB）; 生物学特征
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2021.06.024
文献标志码:
A
摘要:
目的　回顾性分析血清肌酸激酶同工酶（creatine kinase-MB，CK-MB）活性大于总肌酸激酶(creatine kinase，CK)活性的患者生物学特征及其原因。方法　选取2017～2018年陕西省人民医院住院部29 993例住院患者为研究对象，使用全自动生化分析仪速率法检测血清CK活性和免疫抑制法检测血清CK-MB活性，用统计学方法分析CK-MB>CK患者的生物学特征及产生的原因。结果　在29 993例患者中血清CK-MB>CK占0.81%（242/29 993）。总体上在各年龄段中血清CK-MB>CK患者人数差异有统计学意义（χ2=60.626，P=0.000），而且在各年龄段之间血清CK-MB>CK的男性和女性患者人数差异均有统计学意义（χ2=24.787，46.206，均P=0.000）；＜15岁患者中血清CK-MB＞MB人数最多。血清CK-MB＞CK男性患者人数少于女性患者人数（45.87% vs 54.13%），差异具有统计学意义（χ2=13.099，P=0.022），其中15~30岁组男性患者人数明显少于女性患者，差异有统计学意义（χ2=6.962，P=0.008），其他年龄段男女患者人数差异无统计学意义（χ2=0.249~3.931，均P＞0.05）。血清CK-MB＞CK患者所患疾病中，感染性疾病占44.2%（107/242），恶性肿瘤占20.7%（50/242），其他疾病共占35.1%（85/242）。结论　明确血清CK-MB＞CK患者生物学特征及与所患疾病的关系，有助于临床鉴别诊断相关疾病。
Abstract:
Objective　Retrospective analysis on biological characteristics of patients with serum CK-MB-to-total-CK ratio more than 1.0 (CK-MB>CK) was performed. Methods　29 993 patients were recruited from inpatient departments of Shaanxi Provincial Hospital from January 2017 to December 2018. Serum CK activity and CK-MB activity were detected by automatic biochemical analyzer with rate method and immunosuppression methods, respectively. Results　The patients with serum CK-MB>CK accounted for 0.81% (242/29 993). Generally, there existed statistical differences for the number of patients with serum CK-MB>CK between age groups（χ2=60.626, P=0.000）. There existed significantly statistical difference between age groups for male patients with serum CK-MB>CK (χ2=24.787，P=0.000) as well as female ones （χ2=46.206，P=0.000）.There were the most male patients with CK-MB>CK younger than 15 years old as well as female ones（45.87% vs 54.13%）. The male patients with CK-MB>CK was statistically less than that of female ones，the difference was significantly statistical（χ2=13.099，P=0.022）. The female patients aged from 10 to 15 years old with CK-MB>CK were more than those of male ones (χ2=6.962，P=0.008) and there were no statistical differences between other age groups（χ2=0.249~3.931，all P>0.05）. 44.2% (107/242) of patients with serum CK-MB>CK had infectious diseases, 20.7% (50/242) malignant tumors and 35.1% (85/242) other diseases. Conclusion　The investigation was helpful for further understanding biological characteristics of patients with serum CK-MB>CK and clinical differential diagnosis.

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更新日期/Last Update: 1900-01-01