[1]洪　毅,王　华.20例非ABO-HDFN血型血清学分析及临床干预结果比较[J].现代检验医学杂志,2021,36(06):120-123.[doi:10.3969/j.issn.1671-7414.2021.06.025]
　HONG Yi,WANG Hua.Comparison of Serological Analysis and Clinical Intervention Results of 20 Non-ABO-HDFN Serum Types[J].Journal of Modern Laboratory Medicine,2021,36(06):120-123.[doi:10.3969/j.issn.1671-7414.2021.06.025]
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20例非ABO-HDFN血型血清学分析及临床干预结果比较()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年06期
页码:
120-123
栏目:
论　著
出版日期:
2021-12-15

文章信息/Info

Title:
Comparison of Serological Analysis and Clinical Intervention Results of 20 Non-ABO-HDFN Serum Types
文章编号:
1671-7414（2021）06-120-04
作者:
洪　毅1; 王　华2
（1．西安高新医院输血科，西安 710075；2.陕西省人民医院，西安 710068）
Author(s):
HONG Yi;  WANG Hua
（1. Department of Blood Transfusion, Xi’an High-Tech Hospital ，Xi’an 710075，China; 2. Shaanxi Provincial People’s Hospital, Xi’an 710068，China）
关键词:
新生儿溶血病; 意外抗体; 非ABO-胎儿/新生儿溶血病
分类号:
R457.11
DOI:
10.3969/j.issn.1671-7414.2021.06.025
文献标志码:
A
摘要:
目的　探讨意外抗体致非ABO-胎儿/新生儿溶血病（non-ABO hemolytic disease of the fetus and newborn, non-ABO HDFN）血型血清学分析及临床干预结果比较，为临床准确诊治提供参考。方法　回顾性分析2015年1月~2020年8月期间新生儿科送检，陕西省血液中心血型参比室进行检测并最终证实的20例非ABO-HDFN病例，鉴定20例母亲血清及患儿红细胞放散液中的意外抗体及效价；并按照临床干预方式的不同，将患儿分为光疗组、光疗后换血组和光疗后输血组，采用Kruskal-Wallis检验比较三组之间平均住院天数的差异。结果　20例非ABO-HDFN涉及到4个血型系统的9种意外抗体。三组之间平均住院天数比较，输血组平均住院天数最高（15.8±6.94天），换血组次之（11.25±2.86天），光疗组最短（8.5±1.89天）,三组之间平均住院天数差异有统计学意义（χ2=8.046，P=0.018)。结论　血型血清学检测分析是提高由意外抗体致非ABO-HDFN重要检测手段，临床应根据检出抗体的特性及患儿的病情轻重来评估其风险，及时对患儿采取必要的干预手段，对改善患儿预后具有参考价值。
Abstract:
Objective　To explore the analysis of serological analysis and clinical intervention results of accidental antibody-to-non-ABO-HDFN, and to provide reference for clinical accuracy. Methods　Retrospective analysis of neonatal department delivery from January 2015 to August 2020, blood type reference room of Shaanxi Province Blood Center for testing and final confirmation of 20 cases of non-ABO-HDFN cases, identification of 20 cases of mother serum and children in red blood cell release fluid accidental antibodies and efficacy. According to the different clinical intervention methods, the children were divided into three groups of phototherapy group, phototherapy transfusion group and phototherapy transfusion group, and the difference of average hospital days between the tcompared by Kruskal-Wallis test. Results　Twenty cases of non-ABO fetal neonatal hemolysis involved 9 unexpected antibodies in 4 blood type systems. Compared with the average number of hospital days between the three groups, the blood transfusion group had the highest average number of hospital days (15.8±6.94day), the second-lowest number of blood transfusion groups (11.25±2.86day), and the shortest phototherapy group (8.5±1.89day), the difference in the average number of hospital days between the three groups was statistically significant (χ2=8.046, P = 0.018). Conclusion　Serological detection and analysis of blood type is an important detection method to improve the non-ABO-HDFN caused by accidental antibodies, and the clinical should evaluate the risk according to the characteristics of detected antibodies and the severity of the disease in the child, and take the necessary intervention measures for the child in time, which is of reference value to improve the prognosis of the child.

参考文献/References:

[1] 屈柯暄，周丽华，王淑霞，等. 新生儿ABO 溶血病微柱凝集法放散试验中放散液剂量优化研究[J]. 现代检验医学杂志, 2019,34(3):121-123，127.QU Kexuan, ZHOU Lihua, WANG Shuxia, et al.Study on different doses of diffuser in serological testof ABO-hemolytic disease of newborns[J]. Journal ofModern Laboratory Medicine，2019,34(3):121-123，127.
[2] MUNDY C A, BHATIA J. Immunoglobulin transfusionin hemolytic disease of the newborn: place intherapy[J]. International Journal of Clinical TransfusionMedicine, 2015, 3 (default) : 41-45.
[3] METCALF R A，KHAN J，ANDREWS J，etal. Severe ABO hemolytic disease of the newbornrequiring exchange transfusion[J]. Journal of PediatricHematology/Oncology, 2019, 41(8) : 632-634.
[4] 尚红, 王毓三, 申子瑜. 全国临床检验操作规程[S].4 版. 北京: 人民卫生出版社，2015:118-143.SHANG Hong, WANG Yusan, SHEN Ziyu. NationalGuide to Clinical Laboratory Procedures[M]. 4th ed.Beijing: People’s Health Press, 2015:118-143.
[5] 中华医学会儿科学分会新生儿学组,《中华儿科杂志》编辑委员会. 新生儿高胆红素血症诊断和治疗专家共识[J]. 中华儿科杂志, 2014,52(10):745-748.The Group of Neonatology,Society of Pediatrics,Chinese Medical Association, The Editorial Board ofChinese Journal of Pediatrics. There is a consensusamong experts in the diagnosis and treatment ofneonatal high bililinemia[J]. Chinese Journal ofPediatrics, 2014,52(10):745-748.
[6] 刘曦, 范亮峰, 郑皆炜, 等.306 例不规则抗体致新生儿溶血病回顾性研究[J]. 中国输血杂志,2018,31(11):1261-1264.LIU Xi, FAN Liangfeng, ZHENG Jiewei, et al. 306fetus and newborncases with haemolytic disease causedby irregular antibodies: A retrospective study[J].ChineseJournal of Blood Transfusion，2018,31(11):1261-1264.
[7] 杨茹, 李刚, 何欣, 等.Rh，MNS 等血型系统不规则抗体导致新生儿溶血病的实验室检测分析[J]. 临床血液学杂志,2019,32(2):109-112.YANG Ru, LI Gang, HE Xin, et al. Analysis ofneonatal hemolytic disease caused by Rh,MNS bloodtype system irregular antibodies[J]. Journal of ClinicalHematology ,2019,32(2):109-112.
[8] 李璐.280 例新生儿溶血病血清学检测结果分析[J].医学食疗与健康，2020, 18(7): 172，175.LI Lu.Analysis of serological test results of 280 casesof neonatal hemolytic disease[J]. Medical Diet andHealth, 2020, 18(7): 172，175.
[9] 许志远, 林裕翔, 刘亚庆, 等. 罕见抗-JK3 引起新生儿溶血病及家系Kidd 血型基因研究[J]. 北京医学,2017, 39(8):876-879.XU Zhiyuan, LIN Yuxiang, LIU Yaqing, et al. Unusualanti-JK3 causes hemolytic neonatal diseases and geneof Kidd blood group study in their family memebers[J].Beijing Medical Journal, 2017, 39(8):876-879.
[10] HEATHCOTE D J，CARROLL T E，FLOWER RL. Sixty years of antibodies to MNS system hybridglycophorins: what have we learned[J]. TransfusionMedicine Reviews, 2011, 25(2):111-124.
[11] ROBACK J D，FUNG M K, GROSSMAN B J, etal. Technical Manual (Aabb) [M]. 18th Ed. Bethesda:American Association of Blood Banks, 2014：579.

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更新日期/Last Update: 1900-01-01