[1]刘昌贺,李 衡,徐圣杰,等.肝硬化伴肝性脑病与血清IL-6表达水平相关性的meta分析[J].现代检验医学杂志,2022,37(03):56-61.[doi:10.3969/j.issn.1671-7414.2022.03.012]
 LIU Chang-he,LI Heng,XU Sheng-jie,et al.Meta Analysis of the Correlation between Serum Interleukin-6 and Hepatic Encephalopathy in Liver Cirrhosis[J].Journal of Modern Laboratory Medicine,2022,37(03):56-61.[doi:10.3969/j.issn.1671-7414.2022.03.012]
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肝硬化伴肝性脑病与血清IL-6表达水平相关性的meta分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年03期
页码:
56-61
栏目:
论 著
出版日期:
2022-05-15

文章信息/Info

Title:
Meta Analysis of the Correlation between Serum Interleukin-6 and Hepatic Encephalopathy in Liver Cirrhosis
文章编号:
1671-7414(2022)03-056-07
作者:
刘昌贺12李 衡1徐圣杰1郭晶晶3吴清华12
(1. 贵州医科大学, 贵阳 550004;2. 江南大学附属医院, 江苏无锡 214062;3. 南通大学医学院, 江苏南通 226001)
Author(s):
LIU Chang-he12 LI Heng1 XU Sheng-jie1 GUO Jing-jing3WU Qing-hua12
(1. Guizhou Medical University, Guiyang 550004, China;2. Affiliated Hospital of Jiangnan University, Jiangsu Wuxi 214062, China;3.Medical College of Nantong University, Jiangshu Nantong 226001,China)
关键词:
血清白细胞介素-6肝硬化肝性脑病Meta 分析
分类号:
R575.2;R392.11
DOI:
10.3969/j.issn.1671-7414.2022.03.012
文献标志码:
A
摘要:
目的 评价肝硬化伴肝性脑病( hepatic encephalopathy,HE)与血清白细胞介素 -6(serum interleukin-6, sIL-6)水平表达的关系。方法 计算机检索中国生物医学文献( CBM)、知网( CNKI)、维普 (VIP)、万方 (WAN FANG),PubMed,Embase,Web of Science和 Cochrane Library数据库,搜集肝硬化患者中关于 sIL-6水平与 HE相关的病例对照研究,检索时间均为建库至 2021年 4月。根据纳入和排除标准,最终纳入 13个研究,包括 1 479例研究对象,采用 Review Manager Version 5.3进行 meta分析。结果 sIL-6的含量在肝硬化伴 HE组与肝硬化无 HE组比较 [SMD=1.29,95%CI(0.51,2.08),P=0.001],肝硬化伴显性肝性脑病( overt hepatic encephalopathy,OHE)组与肝硬化无 HE组比较 [SMD=2.77,95%CI(1.64,3.89),P< 0.000 01],肝硬化伴轻微肝性脑病( minimal hepatic encephalopathy, MHE)组与肝硬化无 HE组比较 [SMD=2.82,95%CI(1.05,4.58),P=0.002],肝硬化伴 OHE与肝硬化伴 MHE组比较 [SMD=1.82,95%CI(1.30,2.33),P< 0.000 01],肝硬化伴Ⅲ~Ⅳ级 HE组与肝硬化伴Ⅰ~Ⅱ级 HE组比较 [SMD=0.95,95%CI(0.52,1.37),P< 0.000 1],肝硬化伴 MHE与健康对照组比较 [SMD=4.32,95%CI(2.86,5.77), P< 0.000 01],肝硬化无 HE组与健康对照组比较 [SMD=2.23,95%CI(1.34,3.12),P< 0.000 01],差异均有统计学意义。结论 sIL-6的表达水平可能与肝性脑病的发病机制有关,有望成为诊断肝性脑病及判定预后疗效的重要炎症指标,还需要更多高质量、多中心的研究验证。
Abstract:
Objective To evaluate the relationship between Hepatic encephalopathy (HE) and serum interleukin-6 (sIL-6) in liver cirrhosis. Methods Computer retrieval of CBM, CNKI, VIP, WanFang, PubMed, Embase, Web of Science and Cochrane Library database were conducted to retrieve case-control studies related to sIL-6 level and HE. The retrieval time was from the establishment of the database to April 2021. According to inclusion and exclusion criteria, 13 studies were included, including 1 479 subjects, and meta-analysis was performed using Review Manager Version 5.3. Results The levels of sIL-6 were compared between liver cirrhosis with HE group and liver cirrhosis without HE group[SMD=1.29, 95%CI(0.51,2.08), P=0.001]. Comparison between cirrhosis with OHE group and cirrhosis without HE group[SMD=2.77, 95%CI(1.64,3.89), P < 0.000 01]. Comparison of cirrhosis with MHE group and cirrhosis without HE group[SMD=2.82, 95%CI(1.05,4.58), P=0.002]. Cirrhosis with OHE group and cirrhosis with MHE group[SMD=1.82,95%CI(1.30, 2.33), P < 0.000 01]. Comparison of cirrhosis with grade Ⅲ~Ⅳ HE group and cirrhosis with grade Ⅰ~Ⅱ HE group[SMD=0.95,95%CI(0.52,1.37), P < 0.000 1]. Comparison of cirrhosis with MHE group and Healthy control group[SMD=4.32, 95%CI(2.86,5.77), P < 0.000 01]. Comparison of liver cirrhosis without HE group and healthy control group[SMD=2.23, 95%CI(1.34,3.12), P < 0.000 01], the differences among the above groups were statistically significant. Conclusion The increase of sIL-6 may be related to the pathogenesis of hepatic encephalopathy. It is expected to be an important inflammatory indicator for diagnosing hepatic encephalopathy and determining its prognosis. However, more high-quality and multi-center studies are needed to verify the level of sIL-6.

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备注/Memo

备注/Memo:
基金项目:太湖高层次人才项目(编号BJ2020048),无锡市卫健委妇幼科研面上项目(FYKY201902),资助单位:无锡市卫生健康委员会。
作者简介:刘昌贺(1993-),男,在读硕士,住院医师,研究方向:肝性脑病的诊治,E-mail:2421513783@qq.com。
通讯作者:吴清华,男,博士,主任医师,硕士生导师,E-mail:wqhsusan@126.com。
更新日期/Last Update: 1900-01-01