[1]宋林立a,楚淑芳b,袁 瑞a,等.深圳地区非甲状腺疾病人群促甲状腺激素分泌生物节律性的大数据研究[J].现代检验医学杂志,2022,37(04):154-158.[doi:10.3969/j.issn.1671-7414.2022.04.030]
　SONG Lin-lia,CHU Shu-fangb,YUAN Ruia,et al.Study on the Biorhythm of Thyroid-stimulating Hormone Secretion in Shenzhen Population with Non-thyroid Disease Using Big Data[J].Journal of Modern Laboratory Medicine,2022,37(04):154-158.[doi:10.3969/j.issn.1671-7414.2022.04.030]
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深圳地区非甲状腺疾病人群促甲状腺激素分泌生物节律性的大数据研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年04期
页码:
154-158
栏目:
研究简报·实验技术
出版日期:
2022-07-15

文章信息/Info

Title:
Study on the Biorhythm of Thyroid-stimulating Hormone Secretion in Shenzhen Population with Non-thyroid Disease Using Big Data
文章编号:
1671-7414（2022）04-154-05
作者:
宋林立a; 楚淑芳b; 袁 瑞a; 余文辉a; 何进才a; 吴 嘉c; 张书楠a; 张春雷a
广州中医药大学第四临床医学院深圳市中医院a. 检验科；b. 内分泌科；c. 计算机中心，广东深圳 518033
Author(s):
SONG Lin-lia;  CHU Shu-fangb;  YUAN Ruia;  YU Wen-huia;  HE Jin-caia;  WU Jiac;  ZHANG Shu-nana;  ZHANG Chun-leia
a. Department of Clinical Laboratory；b. Department of Endocrinology and Metabolism；c. Computer Center， Shenzhen Traditional Chinese Medicine Hospital Affiliated to the Fourth Clinical College of Guangzhou University of Chinese Medicine, Guangdong Shenzhen 518033,China
关键词:
促甲状腺激素; 生物节律; 深圳人群; 大数据
分类号:
R581；R446
DOI:
10.3969/j.issn.1671-7414.2022.04.030
文献标志码:
A
摘要:
目的 研究深圳地区非甲状腺疾病人群促甲状腺激素(thyroid-stimulating hormone, TSH) 分泌的节律性，为甲状腺疾病的诊治提供新的思路。方法 利用大数据技术挖掘2020 年1 月1 日～ 2021 年11 月31 日深圳市中医院计算机中心数据库的促甲状腺激素检验结果108 071 例。剔除具有明确诊断的甲状腺癌、原发性甲状腺功能亢进或甲状腺功能减退患者3 393 例，缺失值7 289 例和离群值4 040 例后，余下93 349 例为研究总体，其中男性30 547 例，女性62 802 例，平均年龄35 (42±15) 岁。首先，对总体进行正态检验，再根据血液样本采集时间（5:00 ～ 16:00）及时间间隔1h 将其分成12 组，分析TSH 分泌的生物节律。多组间比较采用单因素方差分析。结果 TSH 值呈偏态分布。不同组间TSH中位值的最大偏差为31.4%。峰值出现于上午8:00，谷值出现于下午3:00。单因素方差分析显示，各组TSH 值的差异具有统计学意义（F=99.09, P ＜ 0.01）。TSH 值的周期性变化，总体上呈现上午高、下午低。结论 深圳地区非甲状腺疾病人群TSH 分泌具有明显的生物节律性。
Abstract:
Objective To study the biorhythm of thyroid stimulating hormone (TSH) secretion in people with non thyroid diseases in Shenzhen, so as to provide new ideas for the diagnosis and treatment of thyroid diseases. Methods A total of 108 071 cases with TSH test results were collected in the database of Computer Center of Shenzhen Traditional Chinese Medicine Hospital Affiliated to the Fourth Clinical College of Guangzhou University of Chinese Medicine from January 1, 2020 to November 31, 2021,excluding 3 393 patients with thyroid cancer, primary hyperthyroidism or hypothyroidism, 7 289 missing values and 4 040 outliers, the remaining 93 349 patients were the study population, including 30 547 males and 62 802 females, with an average age of 35 (42 ± 15) years. Firstly, the normality test was excuted on the total cases, and then the blood samples were divided into 12 groups according to the sampling time (5:00 ～ 16:00) and the time interval of 1h, and the biorhythm of TSH secretion among different groups were analyzed.Comparison between multiple groups was performed by one-way ANOVA. Results The distribution of TSH values showed a skewness. The maximum deviation of median TSH between different groups was 31.4%. The acrophase appeared at 8:00 a.m. and the trough appeared at 3:00 p.m.One-way ANOVA showed that TSH values were significantly different among groups (F=99.09, P ＜ 0.01). Generally, there was a periodical variation of TSH values, higher in a.m. and lower in p.m. Conclusion There was an obvious biorhythm of TSH secretion in Shenzhen population with nonthyroid diseases.

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相似文献/References:

[1]王　玲,王　健,赵寅生,等.甲状腺乳头状癌患者血清促甲状腺激素水平和组织促甲状腺激素受体检测的临床应用价值[J].现代检验医学杂志,2021,36(01):61.[doi:10.3969/j.issn.1671-7414.2021.01.016]
　WANG Ling,WANG Jian,ZHAO Yin-sheng,et al.Clinical Application Value of Serum Thyrotropin Level and Tissue Thyrotropin Receptor Detection in Patients with Thyroid Papillary Carcinoma[J].Journal of Modern Laboratory Medicine,2021,36(04):61.[doi:10.3969/j.issn.1671-7414.2021.01.016]

备注/Memo

备注/Memo:
基金项目：深圳市科技计划项目（JCYJ20180302173821841）。
作者简介：宋林立（1980-），男，本科，主管技师，研究方向：临床生化检验与质量控制，E-mail: songlinli1980@163.com。
通讯作者：余文辉（1964-），男，本科，主任技师，硕士生导师，研究方向：临床生化检验与内分泌疾病，E-mail: whyuchina@163.com。
更新日期/Last Update: 1900-01-01