[1]杨 婷a,赵茜茜,褚 杰a,等.慢性心力衰竭患者血清MCP-3，NRG-1β 和CF6 水平表达与疾病严重程度的相关性研究[J].现代检验医学杂志,2022,37(05):139-142+175.[doi:10.3969/j.issn.1671-7414.2022.05.027]
　YANG Tinga,ZHAO Qian-qian,CHU Jiea,et al.Study on the Correlation between the Expression of Serum MCP-3, NRG-1β and CF6 Levels in Patients with Chronic Heart Failure and the Severity of the Disease[J].Journal of Modern Laboratory Medicine,2022,37(05):139-142+175.[doi:10.3969/j.issn.1671-7414.2022.05.027]
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慢性心力衰竭患者血清MCP-3，NRG-1β 和CF6 水平表达与疾病严重程度的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年05期
页码:
139-142+175
栏目:
论著
出版日期:
2022-09-15

文章信息/Info

Title:
Study on the Correlation between the Expression of Serum MCP-3, NRG-1β and CF6 Levels in Patients with Chronic Heart Failure and the Severity of the Disease
文章编号:
1671-7414（2022）05-139-05
作者:
杨 婷1a; 赵茜茜2; 褚 杰1a; 崔晓博1b
1. 张家口市第一医院a. 心内科；b. 感染科，河北张家口 075041；2. 张家口市第一医院东院区检验科，河北张家口 075041
Author(s):
YANG Ting1a; ZHAO Qian-qian2; CHU Jie1a; CUI Xiao-bo1b
1a.Department of Cardiology；1b.Department of Infectious Disease, the First Hospital of Zhangjiakou City, Hebei Zhangjiakou 075041，China; 2. Department of Clinical Laboratory, East Campus of the First Hospital of Zhangjiakou, Hebi Zhangjiakou 075041, China
关键词:
慢性心力衰竭; 单核细胞趋化蛋白-3; 神经调节蛋白1β; 偶联因子6
分类号:
R541.6；R392.11
DOI:
10.3969/j.issn.1671-7414.2022.05.027
文献标志码:
A
摘要:
目的　分析慢性心力衰竭（chronic heart failure，CHF）患者血清单核细胞趋化蛋白-3（monocyte chemoattractantprotein-3，MCP-3），神经调节蛋白1β（neuregulin 1β，NRG-1β）和偶联因子6（coupling factor 6，CF6）水平表达及与疾病严重程度的相关性。方法　选取2019 年8 月～ 2020 年8 月张家口市第一医院收治的慢性心力衰竭患者120 例作为慢性心力衰竭组，另外选取70 例健康人作为健康组，采用酶联免疫吸附（enzyme-linked immunoassay, ELISA）法检测MCP-3，NRG-1β 和CF6 水平，分析MCP-3，NRG-1β 和CF6 在健康组与慢性心力衰竭组的表达及与疾病严重程度的关系。结果　慢性心力衰竭组MCP-3（0.52±0.05 ng/L ），NRG-1β（6.01±0.62 ng/ml）和CF6（304.64±30.58pg/ml）表达相对于健康组升高(0.10±0.01 ng/L, 3.25±0.32 ng/ml，201.62±21.36 pg/ml)，差异均具有统计学意义（t=69.400，34.630，24.860，均P ＜ 0.05）。MCP-3，NRG-1β 和CF6 随着慢性心力衰竭严重程度的加重升高加剧，差异具有统计学意义（F=15.117 ～ 41.816，均P ＜ 0.05）。ROC 曲线显示，与MCP-3（AUC=0.842，95% CI=0.701~0.984），NRG-1β（AUC=0.851，95% CI=0.718~0.984）和CF6（AUC=0.873，95% CI=0.746~1.000）单项诊断相比，三项联合检测对慢性心力衰竭的诊断价值较高（AUC=0.899, 95% CI=0.766~1.030），差异有统计学意义（均P ＜ 0.05）。相关性分析显示MCP-3 与NRG-1β 和CF6 均呈正相关（r=0.593，0.516，0.549, 均P=0.001）。结论　MCP-3，NRG-1β 和CF6在慢性心力衰竭患者中表达升高，且MCP-3，NRG-1β 和CF6 表达升高与患者疾病严重程度相关，可参与慢性心力衰竭的发展。临床可参考上述指标对此病进行早期评估。
Abstract:
Objective　To analyze the serum monocyte chemoattractant protein-3 (MCP-3), neuregulin 1β (NRG-1β) and coupling factor 6 (CF6) levels in patients with chronic heart failure（CHF） and their correlation with the severity of the disease. Methods　From August 2019 to August 2020, 120 patients with chronic heart failure admitted to the eastern district of the First Hospital of Zhangjiakou City as the CHF group, and 70 healthy people were selected as the healthy group, using enzyme-linked immunoassay (ELISA) method to detect the levels of MCP-3, NRG-1β and CF6, and analyzed the expression of MCP-3, NRG- 1β and CF6 in the healthy group and the CHF group and the relationship with the severity of the disease. Results　The expressions of MCP-3 (0.52±0.05 ng/L), NRG-1β (6.01±0.62 ng/ml), and CF6 (304.64±30.58 pg/ml) in the CHF group were higher than those in the healthy group(0.10±0.01 ng/L, 3.25±0.32 ng/ml，201.62±21.36 pg/ml),the differences were statistically significant(t=69.400, 34.630, 24.860, all P ＜ 0.05).MCP-3, NRG-1β and CF6 increased with the severity of CHF the differences were statistically significant(F=15.117 ～ 41.816, all P ＜ 0.05).The ROC curve showed that compared with the single diagnosis of MCP-3(AUC=0.842，95% CI=0.701~0.984), NRG-1β(AUC=0.851，95% CI=0.718~0.984) and CF6(AUC=0.873，95% CI=0.746~1.000), the combination of the three had a higher diagnostic value for CHF (AUC=0.899,95%CI=0.766~1.030), the differences were statistically significant (all P ＜ 0.05). Correlation analysis showed that MCP-3 was positively correlated with NRG-1β and CF6 and NRG-1β was positively correlated with CF6(r=0.593，0.516，0.549, all P=0.001). Conclusion　The expression of MCP-3, NRG-1β and CF6 were increased in patients with CHF, and the increased expression of MCP-3, NRG-1β and CF6 was related to the severity of the patient’s disease, and may participate in the development of CHF . Clinical can refer to the above indicators for early evaluation of the disease.

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备注/Memo

备注/Memo:
基金项目：张家口市科学技术研究项目（1521041D）。
作者简介：杨婷（1981-），女，本科，副主任医师，研究方向：心内科，E-mail：qdi791078@21cn.com。
更新日期/Last Update: 2022-09-15