[1]吕晓丽,张 喆,王 希,等.西安地区临床患者EBV 感染血清学特征及疾病谱分析[J].现代检验医学杂志,2023,38(02):136-139+154.[doi:10.3969/j.issn.1671-7414.2023.02.025 ]
　Lü Xiao-li,ZHANG Zhe,WANG Xi,et al.Serological Characteristics and Disease Spectrum Analysis of Epstein-Barr Virus Infection in Clinical Patients in Xi’an[J].Journal of Modern Laboratory Medicine,2023,38(02):136-139+154.[doi:10.3969/j.issn.1671-7414.2023.02.025 ]
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西安地区临床患者EBV 感染血清学特征及疾病谱分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年02期
页码:
136-139+154
栏目:
论著
出版日期:
2023-03-15

文章信息/Info

Title:
Serological Characteristics and Disease Spectrum Analysis of Epstein-Barr Virus Infection in Clinical Patients in Xi’an
文章编号:
1671-7414（2023）02-136-05
作者:
吕晓丽; 张 喆; 王 希; 林 芳; 黄 晶; 郝 婷; 宁 静; 董 轲
（空军军医大学第二附属医院检验科，西安 710038）
Author(s):
Lü Xiao-li; ZHANG Zhe; WANG Xi; LIN Fang; HUANG Jing; HAO Ting; NING Jing; DONG Ke
(Department of Clinical Laboratory, the Second Affiliated Hospital of Air Force Military Medical University, Xi’an 710038, China)
关键词:
Epstein-Barr病毒; 血清学特征; 疾病谱; 感染状态
分类号:
R373.1；R446.5
DOI:
10.3969/j.issn.1671-7414.2023.02.025
文献标志码:
A
摘要:
目的 分析西安地区临床患者Epstein-Barr病毒 (EBV)感染的血清学特征及临床疾病构成，为临床诊疗提供依据。方法 以 2016 ~2021年空军军医大学第二附属医院就诊的 7 455例有不明原因发热、皮疹、肝脾及淋巴结肿大等感染症状的临床患者作为研究对象，酶联免疫吸附法检测患者血清 EBV抗衣壳抗原抗体 IgM（VCA-IgM）、抗衣壳抗原抗体 IgG（VCA-IgG）、抗核抗原抗体 IgG（EBNA-IgG）及抗早期抗原抗体 IgG（EA-IgG）。回顾性分析患者血清四种抗体检测结果，分析 EBV感染的性别及年龄差异、患者的感染状态及疾病的临床分布。结果 VCA-IgG和 EA-IgG在女性患者中的阳性率均高于男性（92.93% vs 91.23%, 15.93% vs 11.16%），差异具有统计学意义（χ2= 7.269，36.360，均 P<0.05）。随着年龄的增长， VCA-IgG，EBNA-IgG和 EA-IgG占比逐渐增高，均在 41~65岁达高峰分别为 41.16%，42.33%和 44.48%；VCA-IgM在 0~3岁患儿中占比最高，达 24.62%。EA-IgG，VCA-IgM，EBNA-IgG和 VCA-IgG在不同年龄段所占比例不同，差异具有统计学意义（χ2=66.424， 539.576， 1 770.513，2 618.477，均 P <0.05）。临床患者 EBV以既往感染为主，占比 85.88%，急性感染占比 7.78%，无感染占比 6.34%。疾病谱中典型传染性单核细胞增多症（简称传单）69例，占比 6.18%，其余非典型感染中占比最多的是自身免疫性疾病（22.38%），其次是消化系统和呼吸系统疾病，分别占比 16.29%和 13.97%。结论 VCA-IgG和 EA-IgG阳性率在女性患者中大于男性；学龄前患儿为 EBV现症感染的多发人群；临床患者 EBV感染以既往感染为主，急性感染者中疾病分布广泛，多抗体联合检测可为临床诊断提供更详细和可靠的信息。
Abstract:
Objective To investigate the infection situation and serological characteristics of Epstein-Barr virus（EBV）in Xi’an, so as to provide basis for clinical diagnosis and treatment. Methods Taking 7 455 clinical patients with symptoms of infection such as fever, rash, hepatosplenomegaly and lymphadenopathy in the Second Affiliated Hospital of Air Force Military Medical University in 2016~2021 as the research object. Serum EBV anti-capsid antigen antibody IgM (VCA-IgM), anti-capsid antigen antibody IgG (VCA-IgG), anti-nuclear antigen antibody IgG (EBNA-IgG) and anti-early antigen antibody IgG (EA-IgG) were detected by enzyme-linked immunosorbent assay. Results The positive rates of VCA-IgG and EA-IgG in female patients were higher than those in men(92.93% vs 91.23%. 15.93 vs 11.16%), and the differences were statistically significant (χ2=7.269， 36.360, all P<0.05). With the increase of age, the proportion of VCA-IgG, EBNA-IgG and EA-IgG gradually increased, and the peaks were 41.16%, 42.33% and 44.48% at the age of 41~65, respectively. VCA-IgM accounted for the highest proportion among children aged 0~3 years, reaching 24.62%. The proportions of EA-IgG, VCA-IgM, EBNA-IgG and VCA-IgG in different age groups were statistically significant (χ2=66.424, 539.576, 1770.513, 2618.477, all P< 0.05). EBV in clinical patients was mainly previous infection, accounting for 85.88%, acute infection accounted for 7.78%, and no infection accounted for 6.34%. Among the disease spectrum, 69 cases were typical infectious mononucleosis, accounting for 6.18%. Among the other atypical infections, autoimmune diseases accounted for 22.38%, followed by digestive system diseases and respiratory system diseases, accounting for 16.29% and 13.97% respectively. Conclusion Among the four antibodies, the positive rates of VCA-IgG and EA-IgG were higher in female patients than in male patients. Preschoolers were the most prone to EBV infection. EBV infection in clinical patients is mainly previous infection, and the disease was widely distributed in acute infected patients. Combined detection of multi-antibody can provide more detailed and reliable information for clinical diagnosis.

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备注/Memo

备注/Memo:
收稿日期：2022-08-05修回日期：2022-11-28
作者简介：吕晓丽（1985-），女，硕士，主管技师，主要从事免疫学及分子生物学检验工作， E-mail：unkindlxl@163.com。
通讯作者：董轲，男，主任医师，E-mail：drdongke@163.com。

更新日期/Last Update: 2023-03-15