[1]肖二明,金晓艳,杨常栓.新生儿坏死性小肠结肠炎患儿血清Galectin 3 和IGF-1 表达及临床意义[J].现代检验医学杂志,2023,38(02):166-170.[doi:10.3969/j.issn.1671-7414.2023.02.031 ]
　XIAO Er-ming,JIN Xiao-yan,YANG Chang-shuan.Expression and Clinical Significance of Serum Galectin-3 and IGF-1 in Children with Neonatal Necrotizing Enterocolitis[J].Journal of Modern Laboratory Medicine,2023,38(02):166-170.[doi:10.3969/j.issn.1671-7414.2023.02.031 ]
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新生儿坏死性小肠结肠炎患儿血清Galectin 3 和IGF-1 表达及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年02期
页码:
166-170
栏目:
检验与临床
出版日期:
2023-03-15

文章信息/Info

Title:
Expression and Clinical Significance of Serum Galectin-3 and IGF-1 in Children with Neonatal Necrotizing Enterocolitis
文章编号:
1671-7414（2023）02-166-05
作者:
肖二明1; 金晓艳2; 杨常栓2
(1.廊坊市妇幼保健院新生儿科 ,河北廊坊 065000；2.解放军总医院第七医学中心，北京 100700）
Author(s):
XIAO Er-ming1;  JIN Xiao-yan2;  YANG Chang-shuan2
(1. Department of Neonatology, Langfang Maternal and Child Health Hospital, Hebei Langfang 065000,China;2. the Seventh Medical Center of PLA General Hospital, Beijing 100700, China)
关键词:
新生儿坏死性小肠结肠炎; 半乳糖凝集素 3; 胰岛素样生长因子 -1
分类号:
R574.5；R392.11
DOI:
10.3969/j.issn.1671-7414.2023.02.031
文献标志码:
A
摘要:
目的 研究坏死性小肠结肠炎 (necrotizing enterocolitis ，NEC)患儿血清半乳糖凝集素 3(Galectin-3，Gal-3) 和胰岛素样生长因子 -1（insulin-like growth factor-1，IGF-1）的表达及临床意义。方法 选取 2019年 1月～2021年 2月廊坊市妇幼保健院诊治的 80例 NEC患儿为研究对象（NEC组），根据 NEC严重程度分为轻度 NEC组（n =50）和重度 NEC组（n =30），同期诊治的 50例非 NEC患儿为对照组。应用酶联免疫吸附实验检测血清 Gal 3和 IGF-1水平，比较各组间血清 Gal-3和 IGF-1表达差异。多因素 Logistic回归分析影响重度 NEC发生的因素，受试者工作曲线分析血清 Gal-3和IGF-1及联合检测对重度NEC的诊断价值。结果 NEC组血清 Gal-3（5.24±0.79ng/ml）和 IGF 1（51.67±16.34ng/ ml）水平显著高于对照组（2.13±0.47ng/ml，117.42±31.73ng/ml），差异具有统计学意义（t=7.685，13.884，均 P＜ 0.001）。重度 NEC组新生儿气腹征发生率 (53.33%)，MODS发生率 (46.67%)及 Gal-3水平 (5.94±0.71ng/ml)明显高于轻度 NEC组 (4.00%，6.00%，4.82±0.79ng/ml)，重度 NEC组血清 IGF-1水平 (37.60±16.67ng/ml )明显低于轻度组 (60.11±18.35ng/ ml)，差异均有统计学意义（t/χ2=5.493～26.170，均 P＜ 0.001）。并发气腹征、并发 MODS、Gal-3升高、 IGF-1降低是影响重度 NEC发生的独立危险因素（均 P＜ 0.05）。血清 Gal-3，IGF-1联合检测对重度 NEC诊断的曲线下面积 (95%CI)为 0.856（0.813～0.904），显著高于血清 Gal-3和 IGF-1单一指标检测的 0.794（0.740～0.848）和 0.760（0.713～0.809），差异具有统计学意义（Z=2.314，3.173，P=0.021，0.002）。结论 NEC患儿血清 Gal-3水平升高， IGF-1水平降低，两者与 NEC疾病严重程度有关，是影响重度 NEC发生的独立因素。
Abstract:
Objective To study the serum Galectin-3(Gal-3) and insulin-like growth factor-1(IGF-1) in children with necrotizing enterocolitis (NEC) expression and clinical significance. Methods From January 2019 to February 2021, 80 NEC children diagnosed and treated in Langfang Maternal and Child Health Hospital were selected as the research objects (NEC group). According to the severity of NEC, it was divided into mild group (n=50) and severe group (n=30). 50 non-NEC children diagnosed and treated during the same period were selected as the control group. Serum Gal-3 and IGF-1 levels were detected by enzyme-linked immunosorbent assay. The expression difference of serum Gal-3 and IGF-1 among the three groups was compared. Multivariate Logistic regression analysis were used to analyze factors affecting the occurrence of severe NEC. Receiver operating curve analysis were used to analyze the diagnostic value of serum Gal-3, IGF-1 and combined detection in severe NEC. Results The levels of serum Gal-3 (5.24±0.79 ng/ml) and IGF-1 (51.67±16.34ng/ml ) in NEC group were significantly higher than those in control group (2.13±0.47ng/ml, 117.42±31.73ng/ml), with statistically significant differences (t=7.685, 13.884, all P<0.001). The incidence of pneumoperitoneum (53.33%), MODS (46.67%) and Gal-3 level (5.94±0.71ng/ ml) in severe NEC group were significantly higher than those in mild NEC group (4.00%, 6.00%, 4.82±0.79ng/ml), and the serum IGF-1 level (37.60± 16.67ng/ml) in severe NEC group was significantly lower than that in mild NEC group (60.11±18.35ng/ml), with statistically significant differences(t/χ2=5.493～26.170, all P＜ 0.001). Combined pneumoperitoneum, combined MODS, increased Gal-3, and decreased IGF-1 were independent risk factors for the occurrence of severe NEC. The area under the curve (95% CI) of the combined detection of serum Gal-3 and IGF-1 for the diagnosis of severe NEC was 0.856 (0.813～0.904), which was significantly higher than that of serum Gal-3 and IGF-1 single indicator detection 0.794 (0.740～0.848) and 0.760 (0.713～0.809) (Z=2.314, 3.173, P=0.021, 0.002). Conclusion Serum Gal-3 level increased and IGF-1 level decreased in children with NEC, both of which were related to the severity of NEC disease and were independent factors affecting the occurrence of severe NEC.

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备注/Memo

备注/Memo:
收稿日期：2022-09-21 修回日期：2022-11-13
基金项目：河北省重点科技研究计划（20180052）。
作者简介：彭凤翔（1969-），女，本科，副主任医师，主要从事临床病理诊断及相关研究， E-mail:dongyandf@163.com。

更新日期/Last Update: 2023-03-15