[1]李一帆,王 丹,王瑞琳,等.革兰氏阴性菌外膜囊泡在抗肿瘤治疗中的研究进展[J].现代检验医学杂志,2023,38(04):201-204.[doi:10.3969/j.issn.1671-7414.2023.04.037]
　LI Yifan,WANG Dan,WANG Ruilin,et al.Research Progress of Gram-negative Bacterial Outer Membrane Vesicles in Anti-tumor Therapy[J].Journal of Modern Laboratory Medicine,2023,38(04):201-204.[doi:10.3969/j.issn.1671-7414.2023.04.037]
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革兰氏阴性菌外膜囊泡在抗肿瘤治疗中的研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年04期
页码:
201-204
栏目:
综述
出版日期:
2023-07-15

文章信息/Info

Title:
Research Progress of Gram-negative Bacterial Outer Membrane Vesicles in Anti-tumor Therapy
文章编号:
1671-7414（2023）04-201-04
作者:
李一帆1; 王 丹1; 王瑞琳1; 费 冰1; 刘 莹1; 任彦颖1; 郭梦雨1; 刘心伟2; 李永伟2
（1. 河南中医药大学，郑州 450046；2. 河南中医药大学第二附属医院，郑州 450002）
Author(s):
LI Yifan1; WANG Dan1; WANG Ruilin1; FEI Bing1; LIU Ying1; REN Yanying1; GUO Mengyu1; LIU Xinwei2; LI Yongwei2
（1.Henan University of Chinese Medicine, Zhengzhou 450046，China； 2.the Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002,China）
关键词:
外膜囊泡; 肿瘤靶向治疗; 肿瘤免疫; 药物载体; 肿瘤疫苗
分类号:
R730.43
DOI:
10.3969/j.issn.1671-7414.2023.04.037
文献标志码:
A
摘要:
革兰氏阴性菌释放的细胞外囊泡源于细胞最外层膜，被称为外膜囊泡（outer membrane vesicles，OMVs），含有磷脂、脂多糖（lipopolysaccharide，LPS）、外膜蛋白（outer membrane proteins，OMPs）和细菌特异性抗原等细菌外膜成分。鉴于OMVs 的纳米中空结构、高度的免疫原性以及有效激活宿主免疫系统等功能，其作为免疫佐剂、肿瘤免疫治疗剂及抗肿瘤药物递送载体和肿瘤疫苗方面具有良好的应用前景。从OMVs 的结构组成、形成机制和抗肿瘤应用等方面综述OMVs 进行靶向和免疫治疗肿瘤的潜力，为临床上抗肿瘤治疗开发新的策略。
Abstract:
Gram-negative bacteria release extracellular vesicles originating from the outermost membrane of the cell, called outer membrane vesicles (OMVs), which contain bacterial outer membrane components such as phospholipids, lipopolysaccharide (LPS), outer membrane proteins (OMPs), and bacterial-specific antigens. In view of the nano hollow structure, high immunogenicity and effectively activate the host immune system, OMVs have good application prospects as immune adjuvants, tumor immunotherapeutic agents, and delivery vectors for anti tumor drugs and tumor vaccines. The potential of OMVs for targeting and immunotherapy of tumors is reviewed in terms of their structural composition, formation mechanism, and antitumor applications, and develops new strategies for clinical anti-tumor therapy.

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备注/Memo

备注/Memo:
作者简介：李一帆（1998-），女，在读硕士，研究方向：医学技术，E-mail:m18437236705@163.com。
通讯作者： 李永伟（1969-），男，博士，主任技师，主要从事医学检验工作，E-mail:lyw@hactcm.edu.cn。
刘心伟（1983-），男，硕士，副主任技师，主要从事微生物检验工作，E-mail:43154727@qq.com。
更新日期/Last Update: 2023-07-15