[1]薛飞肖,李琼阁,宁 可,等.MTHFR 基因多态性与糖尿病周围神经病发生风险的meta 分析[J].现代检验医学杂志,2023,38(05):142-147.[doi:10.3969/j.issn.1671-7414.2023.05.027]
　XUE Feixiao,LI Qiongge,NING Ke,et al.Risk of MTHFR Gene Polymorphism and Diabetic Peripheral Neuropathy： A Meta-Analysis[J].Journal of Modern Laboratory Medicine,2023,38(05):142-147.[doi:10.3969/j.issn.1671-7414.2023.05.027]
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MTHFR 基因多态性与糖尿病周围神经病发生风险的meta 分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年05期
页码:
142-147
栏目:
论著
出版日期:
2023-09-15

文章信息/Info

Title:
Risk of MTHFR Gene Polymorphism and Diabetic Peripheral Neuropathy： A Meta-Analysis
文章编号:
1671-7414（2023）05-142-06
作者:
薛飞肖1; 李琼阁2; 宁 可1; 王 威1; 王海峰1
（1. 西安市第三医院检验科， 西安710018；2. 西安市人民医院/ 西安市第四医院药剂科，西安 710004）
Author(s):
XUE Feixiao1; LI Qiongge2; NING Ke1; WANG Wei1; WANG Haifeng1
（1. Department of Clinical Laboratory, the Third Hospital of Xi’an，Xi’an 710018，China；2. Department of Pharmacy, Xi’an People’s Hospital/the Fourth Hospital of Xi’an，Xi’an 710004，China）
关键词:
亚甲基四氢叶酸还原酶; 糖尿病周围神经病; 基因多态性; Meta 分析
分类号:
R587.2；Q786
DOI:
10.3969/j.issn.1671-7414.2023.05.027
文献标志码:
A
摘要:
目的 分析亚甲基四氢叶酸还原酶（methylenetetrahydrofolate reductase，MTHFR）基因多态性与糖尿病周围神经病（diabetic peripheral neuropathy，DPN）发生风险的关系。方法 计算机检索PubMed，the Cochrane Library，Embase，中国知网和万方医学网数据库自建库～ 2021 年11 月发表的关于MTHFR C677T 基因多态性与DPN 相关的病例对照研究，采用纽卡斯尔- 渥太华评价表(Newcastle-Ottawa Scale ，NOS) 评价文献质量。以比值比(odds ratio，OR)为效应指标，统计学分析采用RevMan5.3 软件。结果 共纳入9 项病例对照研究，包括751 例病例组和854 例对照组。Meta 分析显示，T 等位基因（R=1.54，95%CI: 1.08 ～ 2.18）与DPN 发生风险相关，差异有统计学意义（Z=2.41，P=0.02）。亚组分析显示，中国MTHFR C677T 基因多态性与DPN 发生风险相关（T vs C：OR=2.04，95%CI：1.21 ～ 3.44；TT vs CC：OR=3.90，95%CI：1.46 ～ 10.37；TC vs CC：OR=1.59，95%CI：1.05 ～ 2.40；TT+TC vs CC：OR=2.19，95%CI：1.03 ～ 4.66；CC+TC vs TT：OR=0.36，95%CI：0.19 ～ 0.68），差异有统计学意义（Z=2.68，2.72，2.21，2.03，3.12，均P<0.05）。土耳其TT 基因型与DPN 风险相关（TT vs CC：OR=3.58，95%CI：1.59 ～ 8.03；CC+TC vs TT：OR=0.31，95%CI：0.14 ～ 0.69），差异有统计学意义（Z=3.09，2.87，P=0.002，0.004）。伊朗CC+TC 基因型与DPN风险增加有关（CC+TC vs TT：OR=2.84，95%CI：1.03 ～ 7.84），差异有统计学意义（Z=2.02，P=0.04）。德国、意大利MTHFR C677T 基因多态性与DPN 发病风险未见相关性，差异无统计学意义（Z=0.05 ～ 1.05，均P >0.05）。结论 MTHFR C677T 基因多态性与DPN 发生风险可能与国家地区有关，检测该基因有助于中国、土耳其和伊朗人群DPN 发病风险的预判，以期为临床诊疗提供参考。
Abstract:
Objective To analyze the risk of methylenetetrahydrofolate reductase（MTHFR） gene polymorphisms and diabetic peripheral neuropathy (DPN). Methods PubMed, the Cochrane Library, Embase, CNKI, Wanfang Medical databases were searched by computer to the case-control study on the correlation between MTHFR C677T gene polymorphism and DPN until November 2021. The quality of the literature was evaluated by Newcastle-Ottawa Scale （NOS). Statistical analysis was performed using RevMan5.33 and the odds ratio (OR) was used as the effect index. Results A total of 9 case-control studies were included, including 751 cases and 854. Meta-analysis showed that the T allele (OR=1.54,95%CI :1.08 ~ 2.18) was associated with the risk of DPN, and the difference was statistically significant (Z=2.41, P=0.02). Subgroup analysis showed that the polymorphism of MTHFR C677T gene was associated with the risk of DPN in China (T vs C: OR=2.04, 95%CI: 1.21 ~ 3.44, TT vs CC: OR=3.90, 95%CI: 1.46 ~ 10.37 ，TC vs CC: OR=1.59, 95%CI: 1.05 ~ 2.40 ，TT+TC vs CC: OR=2.19, 95%CI: 1.03 ~ 4.66) ，CC+TC vs TT: OR=0.36, 95%CI: 0.19 ~ 0.68), the differences were statistically significant (Z=2.68，2.72，2.21，2.03， 3.12， all P<0.05). Turkish TT genotype was associated with DPN risk (TT vs CC: OR=3.58, 95%CI: 1.59 ～ 8.03，CC+TC vs TT: OR=0.31, 95%CI: 0.14 ～ 0.69), the differences were statistically significant (Z=3.09，2.87，P=0.002, 0.004).The Iranian CC+TC genotype was associated with increased risk of DPN (CC+TC vs TT: OR=2.84, 95%CI: 1.03 ~ 7.84), and the difference was statistically significant (Z=2.02, P=0.04). There was no correlation between MTHFR C677T gene polymorphism and DPN publication risk in Germany and Italy, and the difference was not statistically significant（Z=0.05 ～ 1.05，all P>0.05）. Conclusion MTHFR C677T gene polymorphism and the risk of DPN would be related to countries and regions. Detection of this gene is helpful to predict the risk of DPN in China, Turkey and Iran, so as to provide reference for clinical diagnosis and treatment.

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备注/Memo

备注/Memo:
基金项目：陕西省科技厅重点研发计划项目（NO. 2018SF-090）：ApoE4 基因引起内质网应激促tau 蛋白磷酸化机制研究。
作者简介：薛飞肖（1990-），女，硕士，主管检验技师。研究方向：临床检验诊疗技术，E-mail: aixx0225@sina.com。
通讯作者：王海峰（1971-），男，硕士，主任技师，研究方向：临床检验管理与诊断，E-mail: xasyjykwhf@sina.com。
更新日期/Last Update: 2023-09-15