[1]李婷婷,陈 凤,刘 然.阿尔茨海默病患者血清FGF23 和ZAG 水平表达与认知功能的相关性分析[J].现代检验医学杂志,2023,38(06):166-169.[doi:10.3969/j.issn.1671-7414.2023.06.030]
　LI Tingting,CHEN Feng,LIU Ran.Correlation Analysis between Serum FGF23 and ZAG Levels and Cognitive Function in Patients with Alzheimer’s Disease[J].Journal of Modern Laboratory Medicine,2023,38(06):166-169.[doi:10.3969/j.issn.1671-7414.2023.06.030]
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阿尔茨海默病患者血清FGF23 和ZAG 水平表达与认知功能的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年06期
页码:
166-169
栏目:
检验与临床
出版日期:
2023-11-15

文章信息/Info

Title:
Correlation Analysis between Serum FGF23 and ZAG Levels and Cognitive Function in Patients with Alzheimer’s Disease
文章编号:
1671-7414（2023）06-166-04
作者:
李婷婷; 陈 凤; 刘 然
（内江市第二人民医院精神科，四川内江 641000）
Author(s):
LI Tingting; CHEN Feng; LIU Ran
(Department of Psychiatry, the Second People’s Hospital of Neijiang, Sichuan Neijiang 641000, China)
关键词:
阿尔茨海默病; 成纤维细胞生长因子23; 锌-α-2- 糖蛋白; 认知功能
分类号:
749.16；R446.61
DOI:
10.3969/j.issn.1671-7414.2023.06.030
文献标志码:
A
摘要:
目的 探究阿尔兹海默病（Alzheimer’s disease, AD）患者血清成纤维细胞生长因子23（fibroblast growthfactor 23, FGF23）、锌-α-2- 糖蛋白（zin-α-2 glycoprotein，ZAG）水平与认知功能损伤的相关性。方法 选取2021年4 月～ 2022 年4 月在内江市第二人民医院精神科收治的90 例AD 患者为研究对象（AD 组），另外选取90 例同期在该院体检健康人员作为对照组。酶联免疫吸附法（enzyme linked immunosorbent assay ，ELISA）检测两组血清FGF23 和ZAG 水平。用简易精神状态量表（MMSE）对AD 患者进行认知功能评估。Pearson 法分析AD 患者血清FGF23，ZAG 表达水平与MMSE 评分的相关性。受试者工作特征（receiver operating characteristic, ROC）曲线分析血清FGF23 和ZAG 对AD 患者的诊断价值。结果 与对照组相比，AD 组患者血清FGF23（28.67±7.64 ng/ml vs18.75±4.23 ng/ml），ZAG（22.31±3.26 μg/ml vs 16.43±3.72 μg/ml）表达水平较高，MMSE 评分较低（13.67±1.72分vs 29.56±2.89 分），差异具有统计学意义（t=10.776, 11.278, 44.823, 均P ＜ 0.05）。Pearson 分析显示，AD 患者血清FGF23，ZAG 水平与MMSE 评分均呈负相关（r=-0.611，-0.480，均P ＜ 0.05）。ROC 曲线分析显示，血清FGF23和ZAG 水平诊断AD 的敏感度分别为76.70% 和75.60%，特异度分别为86.70% 和83.30%，曲线下面积（area undercurve, AUC）分别为0.870（95%CI: 0.814 ～ 0.927）和0.849（95%CI: 0.793 ～ 0.906），二者联合检测的敏感度、特异度和AUC 分别为86.70%，88.90%，0.938（95%CI: 0.905 ～ 0.972）。结论 AD 患者血清FGF23 和ZAG 水平升高，二者的表达水平与认知功能障碍呈负相关，可能与该病的发生发展相关。
Abstract:
Objective To investigate the correlation between serum levels of fibroblast growth factor 23 (FGF23), zinc-α-2- glycoprotein (ZAG) and cognitive impairment in patients with Alzheimer’s disease (AD). Methods A total of 90 AD patients admitted to Psychiatric Department of Neijiang Second People’s Hospital from April 2021 to April 2022 were selected as the study subjects, and they were set as the AD group. In addition, 90 healthy individuals who underwent physical examination in the hospital were collected as the control group. The serum levels of FGF23 and ZAG were detected by enzyme linked immunosorbent assay (ELISA). The cognitive function of AD patients was evaluated using the Mini-Mental State Evaluation (MMSE). Pearson method was applied to analyze the correlation between serum FGF23, ZAG expression levels and MMSE scores in AD patients. The evaluation value of serum FGF23 and ZAG in AD patients was analyzed by receiver operating characteristic (ROC) curve analysis. Results Compared with the control group, the expression levels of serum FGF23 (28.67±7.64 ng/ml vs 18.75±4.23 ng/ml) and ZAG (22.31±3.26 μg/ml vs 16.43±3.72 μg/ml) in AD group were higher, and the MMSE (13.67±1.72 points vs 29.56±2.89 points) score was lower, and the differences were statistically significant(t=10.776, 11.278, 44.823, all P ＜ 0.05). Pearson correlation analysis showed that there was a negative correlation between serum FGF23, ZAG levels and MMSE score in AD patients (r=-0.611, -0.480, all P<0.05). ROC analysis showed that serum FGF23 and ZAG levels was able to predict the occurrence of AD, sensitivity of 76.70% and 75.60%, specificity of 86.70% and 83.30%, and area under curve (AUC) of 0.870 (95% CI: 0.814 ～ 0.927) and 0.849 (95% CI: 0.793 ～ 0.906), respectively. The sensitivity, specificity and AUC of the combined detection were 86.70%, 88.90% and 0.938 (95% CI: 0.905 ～ 0.972), respectively.Conclusion The levels of FGF23 and ZAG in serum of AD patients increase, the both expression levels are negatively correlated with cognitive dysfunction, which may be related to the occurrence and development of the disease.

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备注/Memo

备注/Memo:
作者简介：李婷婷（1989-），女，本科，主治医师，研究方向：精神科相关临床研究，E-mail：tplxi21@163.com。
更新日期/Last Update: 2023-11-15