[1]龙 琴,石安惠,黄佳蓉.四川宜宾地区不同孕期妇女血浆可溶性纤维蛋白单体复合物水平参考范围的建立[J].现代检验医学杂志,2024,39(01):166-169.[doi:10.3969/j.issn.1671-7414.2024.01.031]
　LONG Qin,SHI Anhui,HUANG Jiarong.Establishment of Reference Ranges for Plasma Soluble Fibrin Monomer Complex Level at Different Gestational Periods of Women in Yibin Area of Sichuan[J].Journal of Modern Laboratory Medicine,2024,39(01):166-169.[doi:10.3969/j.issn.1671-7414.2024.01.031]
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四川宜宾地区不同孕期妇女血浆可溶性纤维蛋白单体复合物水平参考范围的建立()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年01期
页码:
166-169
栏目:
检验与临床
出版日期:
2024-01-15

文章信息/Info

Title:
Establishment of Reference Ranges for Plasma Soluble Fibrin Monomer Complex Level at Different Gestational Periods of Women in Yibin Area of Sichuan
文章编号:
1671-7414（2024）01-166-04
作者:
龙 琴; 石安惠; 黄佳蓉
（宜宾市妇幼保健院，四川宜宾 644000）
Author(s):
LONG Qin;  SHI Anhui;  HUANG Jiarong
（Yibin Maternal and Child Health Care Hospital, Sichuan Yibin 644000, China）
关键词:
可溶性纤维蛋白单体复合物; 妊娠; 参考范围; 四川宜宾地区
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2024.01.031
文献标志码:
A
摘要:
目的　探究四川宜宾地区不同孕期健康孕妇血浆可溶性纤维蛋白单体复合物（soluble fibrin monomer complex，SFMC）水平的变化，建立不同孕期SFMC 的参考范围。方法　选取2021 年05 月～ 2022 年01 月在宜宾市妇幼保健院就诊的377 例健康孕妇及120 例健康体检者作为研究对象，分为孕早期、孕中期、孕晚期和对照组四组。采用胶乳免疫比浊法检测其血浆SFMC 和D- 二聚体（D-D）水平，建立各组SFMC 的参考范围，同时对二者进行相关性分析。结果　对照组、孕早期组、孕中期组和孕晚期组SFMC 的参考范围分别为<7.3μg/ml，＜ 18.4μg/ml，＜ 20.4μg/ml 和＜ 58.5μg/ml，组间比较，差异具有统计学意义（F=55.989，P ＜ 0.001），且随着孕期的增长，血浆SFMC 水平呈上升趋势。受试者血浆SFMC 水平与D-D 水平呈正相关（r2=0.468 8）。结论　孕妇血浆SFMC 水平随孕期的增加明显上升，正常人群的参考范围不能满足各妊娠期妇女的静脉血栓风险评估。初步建立了孕早期、孕中期和孕晚期妇女血浆SFMC 的参考范围，对孕妇静脉血栓栓塞预防监测具有重要的临床意义。
Abstract:
Objective　To explore the changes in plasma soluble fibrin monomer complex (SFMC) levels at different gestation periods of healthy women in Yibin area of Sichuan and establish reference ranges for SFMC at different gestational stages. Methods　A total of 377 healthy pregnant women and 120 health examinees who received antenatal examination in Yibin Maternal and Child Health Care Hospital from May 2021 to January 2022 were enrolled in this study and grouped into the early pregnant group, the second trimester group, the late pregnant group and control group. The plasma SFMC and D-dimer (D-D) of all groups were detected using the latex immunoturbidimetry and reference ranges of SFMC were established for each group. Meanwhile, the correlation between SFMC and D-D was analyzed at the same time. Results　The reference ranges of SFMC in the control group, the early pregnant group, the second trimester group and the late pregnant group were <7.3μg/ml, <18.4μg/ ml, <20.4μg/ml and <58.5μg/ml, respectively. The difference between groups was statistically significant (F=55.989, P＜0.001), and the plasma SFMC levels showed an upward trend as pregnancy progressed. The SFMC level in plasma was positively correlated with the D-D level (r2=0.468 8). Conclusion　The plasma SFMC levels in pregnant women significantly increased with the progression of pregnancy, and the reference range of the normal population cannot meet the risk assessment of venous thrombosis in pregnant women. This study preliminary established reference ranges for plasma SFMC in women at different gestation periods, which has important clinical significance for monitoring and preventing venous thromboembolism in pregnant population.

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备注/Memo

备注/Memo:
基金项目：宜宾市卫生健康委员会科研项目（编号：2020YW117）：妊娠期D- 二聚体与可溶性纤维蛋白的参考范围建立。
作者简介：龙琴（1982-），女，硕士研究生，副主任技师，研究方向：临床医学检验，E-mail：1079413533@qq.com。
更新日期/Last Update: 2024-01-15