[1]史心怡a,王一婷b,卢 梅a.双相情感障碍患者血清Hepcidin，LncRNA MIAT 和CRE 的水平表达及与病情程度关系研究[J].现代检验医学杂志,2024,39(03):24-28+36.[doi:10.3969/j.issn.1671-7414.2024.03.004]
　SHI Xinyia,WANG Yitingb,LU Meia.Study on the Diagnostic Value of Serum NPASDP-4 and MBP Level Expression with Cognitive Dysfunction and Severity in Parkinson’s Disease Patients[J].Journal of Modern Laboratory Medicine,2024,39(03):24-28+36.[doi:10.3969/j.issn.1671-7414.2024.03.004]
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双相情感障碍患者血清Hepcidin，LncRNA MIAT 和CRE 的水平表达及与病情程度关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年03期
页码:
24-28+36
栏目:
论著
出版日期:
2024-05-15

文章信息/Info

Title:
Study on the Diagnostic Value of Serum NPASDP-4 and MBP Level Expression with Cognitive Dysfunction and Severity in Parkinson’s Disease Patients
文章编号:
1671-7414（2024）03-024-06
作者:
史心怡a; 王一婷b; 卢 梅a
（宝鸡市中心医院 a. 精神卫生科；b. 检验科，陕西宝鸡 721000）
Author(s):
SHI Xinyia;  WANG Yitingb;  LU Meia
（a. Department of Mental Health; b. Department of Clinical Laboratory, Baoji Central Hospital, Shaanxi Baoji 721000, China）
关键词:
双相情感障碍; 铁调素; 长链非编码RNA 心肌梗死转录本; 肌酐
分类号:
R749.4；R392.11
DOI:
10.3969/j.issn.1671-7414.2024.03.004
文献标志码:
A
摘要:
目的 探究双相情感障碍（bipolar disorder，BPD）患者血清铁调素（Hepcidin）、血清长链非编码RNA 心肌梗死转录本（long non-coding RNA myocardial infarction-associated transcript，LncRNA MIAT）和肌酐（creatinine，CRE）表达及与病情程度的关系。方法 选取2021 年3 月～ 2023 年3 月宝鸡市中心医院收治的150 例BPD 患者作为研究对象并纳入BPD 组，另选取健康者150 例为对照组，采用汉密尔顿抑郁量表（Hamilton depression scale，HAMD）评价抑郁，采用杨氏躁狂量表（Young mania ratings scale，YMRS）评价躁狂程度，所有研究对象均接受血清Hepcidin，LncRNA MIAT 和CRE 水平的检测。对比对照组和BPD 组血清Hepcidin，LncRNA MIAT 和CRE 水平；对比不同抑郁、躁狂程度BPD 组血清Hepcidin，LncRNAMIAT 和CRE 水平；受试者工作特征（receiver operating characteristic，ROC）曲线分析血清Hepcidin，LncRNA MIAT 和CRE对BPD的诊断价值；分析血清Hepcidin，LncRNA MIAT和CRE与BPD病情程度的关系。结果 BPD组血清Hepcidin（46.17±9.17ng/L），LncRNA MIAT（11.92±2.65）和CRE（74.02±11.89 μmol/L）水平均明显高于对照组（22.16±5.23 ng/L，4.11±0.95，57.16±8.61μmol/L），差异具有统计学意义（t=-27.856，-43.079，-14.066，均P ＜ 0.05）；随着BPD 患者抑郁、躁狂程度的增加，血清Hepcidin，LncRNA MIAT 和CRE 水平呈现升高的趋势（F=22.036，25.463，17.499；19.552，15.791，18.335，均P ＜ 0.05）；血清Hepcidin，LncRNA MIAT 和CRE 联合检测（95%CI：0.866 ～ 0.949）对BPD 诊断ROC 曲线下面积为0.914，具有较高的特异度和敏感度，显著高于血清Hepcidin（95%CI：0.693 ～ 0.816），LncRNA MIAT（95%CI：0.696 ～ 0.819）和CRE（95%CI：0.587 ～ 0.701）单独检测（AUC=0.759，0.762，0.614，均P ＜ 0.05）；血清Hepcidin，LncRNA MIAT 和CRE 与BPD 患者抑郁严重程度呈显著正相关（r=0.784，0.771，0.826，均P ＜ 0.05）；血清Hepcidin，LncRNA MIAT 和CRE 与BPD 患者躁狂严重程度呈显著正相关（r=0.806，0.793，0.831，均P ＜ 0.05）。结论 BPD 患者血清Hepcidin，LncRNA MIAT 和CRE 水平相较正常人群更高，且与疾病严重程度呈显著正相关，联合检测对其具有较高诊断价值。
Abstract:
Objective To explore the expression of serum Hepcidin, long non-coding RNA myocardial infarction-associated transcript (LncRNA MIAT) and creatinine (CRE) in patients with bipolar disorder (BPD) and their relationship with the severity of the disease. Method In this study, 150 patients with BPD who were admitted to Baoji Central Hospital from March 2021 to March 2023 were selected as the study subjects and were included in the BPD group. Another 150 healthy subjects were selected as the control group. Hamilton Depression Scale (HAMD) was used to evaluate depression. Young mania ratings scale (YMRS) was used to evaluate the degree of mania. All subjects were tested for serum Hepcidin, LncRNA MIAT and CRE levels. The levels of serum Hepcidin, LncRNA MIAT and CRE were compared between control group and BPD group. The levels of serum Hepcidin，LncRNA MIAT and CRE in BPD groups with different depression/mania degrees were compared. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of serum Hepcidin, LncRNA MIAT and CRE in BPD. The relationship between serum Hepcidin, LncRNA MIAT and CRE and the severity of BPD was analyzed. Results The levels of serum Hepcidin（46.17±9.17 ng/L）, LncRNA MIAT（11.92±2.65） and CRE （74.02±11.89 μmol/L）in BPD group were higher than those in control group（22.16±5.23 ng/L, 4.11±0.95, 57.16±8.61μmol/L）, with significant differences (t=-27.856, -43.079, -14.066, all P<0.05). The levels of serum Hepcidin, LncRNA MIAT and CRE increased with the increase of depression/mania in BPD patients (F=22.036, 25.463, 17.499; 19.552, 15.791, 18.335, all P<0.05). The combined detection of serum Hepcidin, LncRNA MIAT and CRE (95%CI: 0.866～0.949) for BPD diagnosis had an area under the ROC curve of 0.914, with high specificity and sensitivity, which was significantly higher than that of serum Hepcidin alone (95%CI: 0.693 ～ 0.816), LncRNA MIAT (95%CI: 0.696 ～ 0.819) alone and CRE (95%CI: 0.587 ～ 0.701) detection alone (AUC=0.759, 0.762, 0.614, all P < 0.05). Serum Hepcidin, LncRNA MIAT and CRE were positively correlated with depression severity in BPD patients (r=0.784, 0.771, 0.826, all P<0.05). Serum Hepcidin, LncRNA MIAT and CRE were positively correlated with mania severity in BPD patients (r=0.806, 0.793, 0.831, all P < 0.05). Conclusion The levels of serum Hepcidin, LncRNA MIAT and CRE in BPD patients were higher than those in the normal population, and they were positively correlated with the severity of the disease. Combined detection may have a high diagnostic value.

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相似文献/References:

[1]左二冬,代　卫,陆　晔,等.放疗相关性贫血患者血清Hepcidin，EPO 表达特征[J].现代检验医学杂志,2020,35(02):43.[doi:10.3969/j.issn.1671-7414.2020.02.013]
　ZUO Er-dong,DAI Wei,LU Ye,et al.Expression Features of Serum Hepcidin and EPO in Tumor Patients withRadiotherapy-Related Anemia[J].Journal of Modern Laboratory Medicine,2020,35(03):43.[doi:10.3969/j.issn.1671-7414.2020.02.013]
[2]王秋云,严　敏,程　珍,等.肿瘤及血液病患者血清 sTRAIL表达及与 IL-6和 Hepcidin水平的相关性研究[J].现代检验医学杂志,2021,36(01):58.[doi:10.3969/j.issn.1671-7414.2021.01.015]
　WANG Qiu-yun,YAN Min,CHENG Zhen,et al.Study of the Expression of the Serum sTRAIL, and Its Correlation with Levels of Serum IL-6 and Hepcidin in the Patients with the Tumor and Hematological Diseases[J].Journal of Modern Laboratory Medicine,2021,36(03):58.[doi:10.3969/j.issn.1671-7414.2021.01.015]

备注/Memo

备注/Memo:
基金项目：陕西省重点研发计划 2020 SF-361：双相情感障碍患者血清因子的水平表达与病情程度关系研究。
作者简介：史心怡 （1993-），女，医学硕士，研究方向：心境障碍、睡眠障碍；E-mail：shixinyi93@21cn.com。
通讯作者：卢梅（1982-），女，医学学士，副主任医师，研究方向：儿童青少年精神障碍的诊疗，E-mail:213024279@qq.com。
更新日期/Last Update: 2024-05-15