[1]纪 栎,张学芳,翟兴荣.孕妇血清CXCL12 和CXCR4 水平检测联合多普勒超声检查在凶险性前置胎盘诊断中的应用价值研究[J].现代检验医学杂志,2024,39(04):161-164,169.[doi:10.3969/j.issn.1671-7414.2024.04.029]
　JI Li,ZHANG Xuefang,ZHAI Xingrong.Value of Serum CXCL12 and CXCR4 Levels Detection in Pregnant Women Combined with Doppler Ultrasound in the Diagnosis of Dangerous Placenta Previa[J].Journal of Modern Laboratory Medicine,2024,39(04):161-164,169.[doi:10.3969/j.issn.1671-7414.2024.04.029]
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孕妇血清CXCL12 和CXCR4 水平检测联合多普勒超声检查在凶险性前置胎盘诊断中的应用价值研究()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年04期
页码:
161-164,169
栏目:
论著
出版日期:
2024-07-15

文章信息/Info

Title:
Value of Serum CXCL12 and CXCR4 Levels Detection in Pregnant Women Combined with Doppler Ultrasound in the Diagnosis of Dangerous Placenta Previa
文章编号:
1671-7414（2024）04-161-05
作者:
纪 栎1，张学芳2，翟兴荣1
（1. 河北省沧州中西医结合医院超声二科，河北沧州 061000；2. 泊头市医院产科，河北沧州 062150）
Author(s):
JI Li1，ZHANG Xuefang2，ZHAI Xingrong1
（1.Department of Ultrasound, Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine in Hebei, Hebei Cangzhou 061000, China；2.Department of Obstetrics, Botou City Hospital, Hebei Cangzhou 062150，China）
关键词:
CXC 趋化因子配体12; CXC 趋化因子受体4; 多普勒超声; 胎盘植入; 凶险性前置胎盘
分类号:
R714.4；R392.11
DOI:
10.3969/j.issn.1671-7414.2024.04.029
文献标志码:
A
摘要:
目的 探讨孕妇血清CXC 趋化因子配体12（CXC chemokine ligand 12，CXCL12）和CXC 趋化因子受体4（CXCchemokine receptor 4，CXCR4）水平检测联合多普勒超声在凶险性前置胎盘诊断中的应用价值。方法 收集2020 年6月～ 2023 年1 月河北省沧州中西医结合医院收治的90 例凶险性前置胎盘患者作为研究对象，根据产后病理结果分为胎盘植入组（n=38）和无胎盘植入组（n=52），另选取同期于河北省沧州中西医结合医院孕检且孕周与患者相匹配的健康孕妇（胎盘附着于子宫前壁）90 例为对照组。比较各组血清CXCL12 和CXCR4 水平；ROC 曲线分析血清CXCL12，CXCR4，多普勒超声对胎盘植入的诊断效能；以术后病理结果为金标准，四表格法计算血清CXCL12，CXCR4 联合多普勒超声对发生胎盘植入的诊断效能。结果 对照组、无胎盘植入组、胎盘植入组血清CXCL12（2.75±1.26 ng/ml，5.82±2.14 ng/ml，10.24±3.58 ng/ml），CXCR4（1.84±0.78 ng/ml，4.47±1.83 ng/ml，8.32±2.763 ng/ml）表达水平依次升高，差异具有统计学意义（F=158.998，199.141，均P<0.05）。CXCL12，CXCR4 和多普勒超声联合检测诊断胎盘植入的AUC 为0.948，敏感度和特异度分别为92.11%，86.54%，优于CXCL12，CXCR4，多普勒超声各自单独预测（Z =2.266，2.682，3.472，P=0.023，0.007，0.001）。结论 凶险性前置胎盘患者血清CXCL12，CXCR4 表达水平显著升高，血清CXCL12 和CXCR4 联合多普勒超声对凶险性前置胎盘患者胎盘植入的发生具有较好的诊断效能。
Abstract:
Objective To explore the application value of serum CXC chemokine ligand 12 (CXCL12) and CXC chemokine receptor 4 (CXCR4) detection combined with Doppler ultrasound in the diagnosis of dangerous placenta previa. Methods A sum of 90 patients with dangerous placenta previa admitted to Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine in Hebei from June 2020 to January 2023 were collected as research subjects. According to the postpartum pathological results, they were grouped into the placental implantation group (n=38) and the non placental implantation group (n=52), while another 90 healthy pregnant women (with placenta attached to the anterior wall of the uterus) who underwent pregnancy examination in Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine in Hebei and matched with the patient’s gestational age were regarded as the control group. The serum levels of CXCL12 and CXCR4 in each group were compared. ROC curve was applied to analyze the diagnostic efficacy of serum CXCL12 and CXCR4 levels for placental implantation. Using postoperative pathological results as the gold standard, the fourfold table method was applied to calculate the diagnostic efficacy of serum CXCL12 and CXCR4 combined with Doppler ultrasound in the occurrence of placental implantation. Results The serum levels of CXCL12 (2.75±1.26 ng/ml, 5.82±2.14 ng/ml, 10.24±3.58 ng/ml) and CXCR4 (1.84±0.78 ng/ml, 4.47±1.83 ng/ml, 8.32±2.763 ng/ml) in the control group, non placental implantation group and placental implantation group were increased successively, and the differences were significant (F=158.998，199.141，all P<0.05). The detection of serum CXCL12 and CXCR4 combined with Doppler ultrasound in the diagnosis of placental implantation had an AUC of 0.948, and sensitivity and specificity were 92.11% and 86.54%, respectively, which was better than CXCL12, CXCR4, and Doppler ultrasound alone predicting separately (Z =2.266, 2.682, 3.472,P=0.023, 0.007, 0.001). Conclusion The expression levels of serum CXCL12 and CXCR4 in patients with dangerous placenta previa are increased. The combination of serum CXCL12 and CXCR4 with Doppler ultrasound may have good diagnostic efficacy for the occurrence of placental implantation in dangerous placenta previa patients.

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备注/Memo

备注/Memo:
基金项目：河北省医学科学研究课题计划项目（编号：20200615）。
作者简介：纪栎（1980-），女，本科，主治医师，研究方向：超声医学，E-mail：a0cwf3@163.com。
更新日期/Last Update: 2024-07-15