[1]古 红,王 静.血管性老年痴呆患者血清Sestrin 2，sFlt-1 水平与认知功能及预后的关系研究[J].现代检验医学杂志,2024,39(05):92-95+119.[doi:10.3969/j.issn.1671-7414.2024.05.017]
　GU Hong,WANG Jing.Study on the Relationship between Serum Sestrin 2, sFlt-1 Levels and Cognitive Function and Prognosis in Patients with Gerontic Vascular Dementia[J].Journal of Modern Laboratory Medicine,2024,39(05):92-95+119.[doi:10.3969/j.issn.1671-7414.2024.05.017]
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血管性老年痴呆患者血清Sestrin 2，sFlt-1 水平与认知功能及预后的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年05期
页码:
92-95+119
栏目:
论著
出版日期:
2024-09-15

文章信息/Info

Title:
Study on the Relationship between Serum Sestrin 2, sFlt-1 Levels and Cognitive Function and Prognosis in Patients with Gerontic Vascular Dementia
文章编号:
1671-7414（2024）05-092-05
作者:
古 红1; 王 静2
（1. 四川大学华西医院老年医学中心/ 干部医疗科，成都 610041；2. 成都市第二人民医院呼吸与危重医学科，成都 610021）
Author(s):
GU Hong1;  WANG Jing2
（1. Geriatrics Center/Department of Cadre Medical, West China Hospital of Sichuan University, Chengdu 610041, China; 2. Department of Respiratory and Critical Care Medicine, Chengdu Second People’s Hospital, Chengdu 610021, China）
关键词:
Sestrin 2; 可溶性血管内皮生长因子受体-1; 血管性痴呆; 认知功能
分类号:
R749.16；R392.11
DOI:
10.3969/j.issn.1671-7414.2024.05.017
文献标志码:
A
摘要:
目的 探索血管性老年痴呆患者血清Sestrin 2，可溶性血管内皮生长因子受体-1（soluble vascular endothelialgrowth factor receptor-1，sFlt-1）水平与认知功能及预后的关系。方法 选取2021 年1 月~2023 年1 月在四川大学华西医院治疗的107 例血管性老年痴呆患者作为研究组，选择同期107 例健康体检者作为对照组。采用酶联免疫吸附法（ELISA）对血清Sestrin 2，sFlt-1 表达水平进行检测，比较不同简易精神状态量表（MMSE）评分患者血清Sestrin 2，sFlt-1 水平；Spearman 法分析血清Sestrin 2，sFlt-1 水平与MMSE 评分的相关性。比较不同预后功能障碍分级血管性老年痴呆患者血清Sestrin 2，sFlt-1 水平；受试者工作特征（ROC）曲线分析血清Sestrin 2，sFlt-1 检测对血管性老年痴呆患者预后功能障碍的预测价值。结果 研究组血清Sestrin2（15.57±1.56ng/ml），sFlt-1（35.68±1.56pg/ml）表达水平高于对照组（11.68±1.46ng/ml, 25.48±2.32pg/ml），差异具有统计学意义（t=18.833，21.363，均P<0.05）。随着MMSE 评分的升高，研究组患者血清Sestrin 2，sFlt-1 水平逐渐降低，差异具有统计学意义（F=134.682，29.284，均P<0.05）。研究组患者血清Sestrin 2，sFlt-1 水平与MMSE 评分呈负相关（r=-0.587，-0.554，均P<0.05）；预后功能障碍分级Ⅲ级患者血清Sestrin 2，sFlt-1 水平高于Ⅰ ~ Ⅱ级患者（t=8.745，10.018，均P<0.05）。Sestrin 2 ，sFlt-1 联合预测的AUC 显著大于Sestrin 2，sFlt-1 单独预测的AUC（Z=2.348，2.059，P=0.019，0.040）。结论 血管性老年痴呆患者血清Sestrin 2，sFlt-1 水平升高，与患者的认知功能密切相关，二者联合具有一定的预后预测价值。
Abstract:
Objective To explore the relationship between serum Sestrin 2, soluble vascular endothelial growth factor receptor-1 (sFlt-1) levels and cognitive function and prognosis in patients with Gerontic Vascular Dementia. Methods A total of 107 patients with vascular dementia treated in West China Hospital of Sichuan University from January 2021 to January 2023 were selected as the study group, and 107 healthy individuals who underwent physical examinations during the same period were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) method was used to detect the expression level of serum Sestrin 2 and sFlt-1. Different Minimum Mental State Examination (MMSE) scores were used to compare the serum Sestrin 2 and sFlt-1 levels of patients. Correlation between the serum Sestrin 2, sFlt-1 levels and the MMSE scores was analyzed by Spearman method. The differences in serum Sestrin 2 and sFlt-1 levels in patients with Gerontic Vascular Dementia with different prognostic dysfunction grades were compared, and the predictive value of serum Sestrin 2, sFlt-1 for prognostic dysfunction in patients with Gerontic Vascular Dementia was analyzed by the receiver operating characteristic (ROC) curve. Results Serum Sestrin 2 (15.57±1.56ng/ml) and sFlt-1(35.68±1.56pg/ml) expression levels were higher in the study group than those in the control group(11.68±1.46ng/ml, 25.48±2.32pg/ml), the differences were statistically significant (t=18.833, 21.363, all P<0.05). Serum Sestrin 2 and sFlt-1 levels were decreased in the patients in study group as the MMSE score increased, and the differences were statistically significant (F=134.682, 29.284, all P<0.05). Serum Sestrin 2 and sFlt-1 levels were negatively correlated with MMSE scores (r=-0.587, -0.554, all P<0.05). Serum Sestrin 2 and sFlt-1 levels of patients with prognostic dysfunction grading III were higher than those in patients with grades I-II (t=8.745, 10.018, all P<0.05). AUC predicted by combination of Sestrin2 and sFlt-1 was greater than AUC predicted by Sestrin 2 and sFlt-1 alone (Z=2.348, 2.059, P=0.019, 0.040). Conclusion Serum levels of Sestrin 2 and sFlt-1 are elevated in patients with vascular dementia, and they are closely related to cognitive function. The combination of the two may have certain prognostic value.

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备注/Memo

备注/Memo:
基金项目：四川省自然科学基金项目（2022NSFSC1463）。
作者简介：古红（1990-），女，本科，研究方向：老年呼吸系统、心血管系统、消化系统疾病等，E-mail：gzxpg5hd@163.com。
更新日期/Last Update: 2024-09-15