[1]褚小余,庄梅红,王 云.儿童特发性矮小症患儿血清C1qA和C1qB水平表达及临床意义[J].现代检验医学杂志,2025,40(01):59-63.[doi:10.3969/j.issn.1671-7414.2025.01.011]
　CHU Xiaoyu,ZHUANG Meihong,WANG Yun.Expression levels of Serum C1qA and C1qB in Children with Idiopathic Nanosomia and Its Clinical Significance[J].Journal of Modern Laboratory Medicine,2025,40(01):59-63.[doi:10.3969/j.issn.1671-7414.2025.01.011]
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儿童特发性矮小症患儿血清C1qA和C1qB水平表达及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年01期
页码:
59-63
栏目:
论著
出版日期:
2025-01-15

文章信息/Info

Title:
Expression levels of Serum C1qA and C1qB in Children with Idiopathic Nanosomia and Its Clinical Significance
文章编号:
1671-7414（2025）01-059-05
作者:
褚小余; 庄梅红; 王 云
（中国人民解放军联勤保障部队第九一零医院儿科，福建泉州 362000）
Author(s):
CHU Xiaoyu; ZHUANG Meihong; WANG Yun
(Department of Paediatrics，the 910th Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China, Fujian Quanzhou 362000,China)
关键词:
特发性矮小症; 补体1qA; 补体1qB; 炎症反应
分类号:
R725.8；R446.62
DOI:
10.3969/j.issn.1671-7414.2025.01.011
文献标志码:
A
摘要:
目的 探讨特发性矮小症（ISS）患儿血清C1qA 和C1qB 表达及临床意义。方法 选择2020 年5 月～ 2023年5 月中国人民解放军联勤保障部队第九一零医院儿科接诊的108 例ISS 患儿（ISS 组）和108 例健康儿童（对照组）。酶联免疫吸附试验（ELISA）检测血清C1qA，C1qB 水平。Pearson 分析ISS 患儿血清C1qA，C1qB 水平与生长发育指标和炎症指标的相关性；多因素Logistic 回归分析ISS 发病的危险因素；受试者工作特征（ROC）曲线分析C1qA，C1qB 诊断ISS 的价值。结果 ISS 组血清C1qA（1 206.35±275.15 ng/ml）和C1qB 水平（1 084.65±220.48 ng/ml）高于对照组（612.35±135.06 ng/ml，501.32±108.77 ng/ml），差异具有统计学意义（t=20.140，24.658，均P ＜ 0.05）。ISS 组身高、体质量、体质量指数（BMI）、骨龄指数低于对照组（t/χ2=2.092 ～ 10.661），ISS 家族遗传史、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平高于对照组（t/χ2=4.338，10.550，15.865），差异具有统计学意义（均P ＜ 0.05）。ISS 患儿血清C1qA 和C1qB 水平与身高、体质量、BMI，骨龄指数呈负相关（r=-0.502 ～ -0.352，均P＜ 0.05），与TNF-α，IL-6 水平呈正相关（r=0.326 ～ 0.411，均P ＜ 0.05）。低骨龄指数、高水平TNF-α、高水平IL-6、高水平C1qA、高水平C1qB 是ISS 发病的危险因素（waldχ2=4.979 ～ 7.328，均P ＜ 0.05）。ROC 曲线显示血清C1qA 和C1qB 诊断ISS 的曲线下面积分别为0.838，0.816，联合检测血清C1qA 和C1qB 诊断ISS 的曲线下面积为0.931，高于两指标单独诊断（Z=3.812，3.896，均P ＜ 0.05）。结论 ISS 患儿血清补体C1qA 和C1qB 水平增高，与ISS 身材矮小有关，联合检测血清C1qA 和C1qB 有助于诊断ISS 风险。
Abstract:
Objective To explore the expression and clinical significance of serum C1qA and C1qB in children with idiopathic short stature (ISS). Methods 108 children with ISS (ISS group) and 108 healthy children (control group) who were admitted to the pediatric department of the 910th Hospital of the Joint Logistics Support Force of the People’s Liberation Army of China from May 2020 to May 2023 were selected. An enzyme-linked immunosorbent assay was used to detect serum levels of C1qA and C1qB. Pearson correlation analysis was used to investigate the correlation between serum C1qA and C1qB levels, growth and development indicators, and inflammatory markers in children with ISS. Multivariate logistic regression analysis was used to identify the risk factors for the onset of ISS and the value of C1qA and C1qB in diagnosing ISS was analyzed based on the working characteristics of the subjects. Results The levels of C1qA (1 206.35±275.15 ng/ml) and C1qB (1 084.65±220.48 ng/ ml) in ISS group were higher than those in control group (612.35±135.06 ng/ml, 501.32±108.77 ng/ml)，the differences were statistically significant (t=20.140，24.658，all P < 0.05).The height, weight, body mass index(BMI ) and bone age index of the ISS group were lower than those of the control group（t/χ2=2.092 ～ 10.661）, and the ISS family history，tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) levels were higher than those of the control group（t/χ2=4.338，10.550，15.865）, the differences were statistically significant (all P < 0.05), respectively .The serum levels of C1qA and C1qB in children with ISS were negatively correlated with height, weight, BMI, and bone age index（r=-0.502 ～ -0.352，all P ＜ 0.05）, and positively correlated with TNF-α and IL-6 levels（r=0.326 ～ 0.411，all P ＜ 0.05）.Low bone age index , high level of TNF-α, high level of IL-6, high level of C1qA and high level of C1qB were risk factors for ISS (waldχ2=4.979 ～ 7.328, all P < 0.05).ROC curve showed that the area under the curve of serum C1qA and C1qB in the diagnosis of ISS was 0.838 and 0.816, respectively. The area under the curve of combined detection of serum C1qA and C1qB in the diagnosis of ISS was 0.931, which was higher than that of two indicators alone (Z=3.812, 3.896, all P < 0.05).Conclusion The serum levels of C1qA and C1qB are increased in children with ISS, which is related to short stature. Combined detection of serum C1qA and C1qB is helpful to diagnose the risk of ISS.

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[1]吴迎爽a,薛向东a,杜志辉a,等.特发性矮小症患儿血清Vaspin和SFRP5水平表达及其诊断价值研究[J].现代检验医学杂志,2024,39(01):95.[doi:10.3969/j.issn.1671-7414.2024.01.017]
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备注/Memo

备注/Memo:
基金项目：福建省卫生健康科技计划项目（2021QNA058）。
作者简介：褚小余（1975-），女，本科，副主任医师，研究方向：呼吸哮喘、消化，内分泌矮小症，E-mail：cxyu250326@163.com。
通讯作者：王云（1965-），男，本科，主任医师，研究方向：儿科重症，内分泌，新生儿，呼吸消化等，E-mail：doctwy@126.com。
更新日期/Last Update: 2025-01-15