[1]许凤婷,杜佳繁,蒋 颖.带状疱疹患者血清STAT3，LncRNA XIST水平表达与疱疹后遗神经痛发生的相关性研究[J].现代检验医学杂志,2025,40(01):73-77+89.[doi:10.3969/j.issn.1671-7414.2025.01.014]
　XU Fengting,DU Jiafan,JIANG Ying.Expression and Clinical Value of Serum STAT3 and LncRNA XIST in Patients with Postherpetic Neuralgia[J].Journal of Modern Laboratory Medicine,2025,40(01):73-77+89.[doi:10.3969/j.issn.1671-7414.2025.01.014]
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带状疱疹患者血清STAT3，LncRNA XIST水平表达与疱疹后遗神经痛发生的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年01期
页码:
73-77+89
栏目:
论著
出版日期:
2025-01-15

文章信息/Info

Title:
Expression and Clinical Value of Serum STAT3 and LncRNA XIST in Patients with Postherpetic Neuralgia
文章编号:
1671-7414（2025）01-073-06
作者:
许凤婷; 杜佳繁; 蒋 颖
（绵阳市中心医院疼痛科，四川绵阳 621000）
Author(s):
XU Fengting; DU Jiafan; JIANG Ying
（Department of Pain, Mianyang Central Hospital, Sichuan Mianyang 621000, China）
关键词:
带状疱疹后遗神经痛; 信号转导和转录激活因子3; 长链非编码RNA X 染色体失活特异转录物
分类号:
R373.11；R392.11
DOI:
10.3969/j.issn.1671-7414.2025.01.014
文献标志码:
A
摘要:
（绵阳市中心医院疼痛科，四川绵阳 621000）
Abstract:
Objective To investigate the expression levels of signal transduction and transcriptional activator 3 (STAT3) and long non-coding RNA X chromosome inactivation specific transcript (LncRNA XIST) in postherpetic neuralgia (PHN) patients and its correlation with PHN disease. Methods From April 2021 to March 2023, 179 patients with postherpetic neuralgia who were admitted to Mianyang Central Hospital were retrospectively regarded as the research objects. According to the occurrence of PHN, they were separated into PHN group (n=43) and non PHN group (n=136). According to the degree of pain, 43 patients with PHN were separated into mild group (n=20)，moderate group (n=16) and severe group (n=7). Meanwhile, 120 patients who had received physical examination in Mianyang Central Hospital were as the control group. Serum STAT3 level was detected using ELISA, and the level of LncRNA XIST was detected using RT-qPCR. Multivariate logistic regression analysis method was applied to analyze the factors that affected the occurrence of PHN. Receiver operating characteristic (ROC) curve was applied to analyze the predictive value of serum STAT3 and LncRNA XIST levels for the occurrence of PHN. Results Compared with the control group, the serum levels of STAT3 (1.44±0.38 ng/L, 2.13±0.51 ng/L vs 0.86±0.20 ng/L) and LncRNA XIST (1.79±0.47, 2.82±0.66 vs 1.05±0.24) in the non PHN group and PHN group were obviously increased (t=14.986, 15.549, 22.894, 25.197), in which the PHN group were higher than the non PHN group (t=9.514, 11.292), and the differences were statistically significant（all P<0.05)．Compared with the mild group, the serum levels of STAT3 (2.21±0.53ng/L, 3.04±0.59 ng/L vs 1.72±0.42 ng/L) and LncRNA XIST (2.96±0.68, 4.15±0.76 vs 2.24±0.51) in the moderate and severe groups were obviously increased (t=3.097, 3.632, 6.443, 7.500), in which the severe group were obviously higher than the moderate group (t=3.343, 3.731)，and the differences were statistically significant (all P<0.05)．Compared with non PHN group, the levels of T helper cell (Th17)/regulatory T cells (Treg) (0.60±0.12 vs 0.54±0.08) and interleukin-10 (IL-10) (29.69±4.58 pg/ml vs 23.57±3.62 pg/ml) in PHN group were obviously higher, and the differences were statistically significant (t/χ2=3.765, 9.040, all P<0.05)．Multivariate Logistic regression analysis showed that STAT3, LncRNA XIST, Th17/Treg, and IL-10 were all independent risk factors affecting the occurrence of PHN (OR=1.157, 1.149, 1.153, 1.125, all P<0.05)．The ROC curve results showed that AUC(95%CI) of serum STAT3 and LncRNA XIST level alone predicted the occurrence of PHN were 0.807 （0.741 ～ 0.862), 0.787 (0.720~0.845), respectively, while the combined prediction AUC(95%CI) of serum STAT3 and LncRNA XIST for PHN was 0.881 (0.824~0.924), which was higher than the AUC predicted by the two alone, and the differences were statistically significant (Z=1.994, 2.175, P=0.046, 0.030). The sensitivity and specificity of the combined prediction were 81.82% and 84.56%, respectively. Conclusion STAT3 and LncRNA XIST are increased in serum of patients with PHN, and the higher the pain degree of patients with PHN, the higher the STAT3 and LncRNA XIST are. The combined detection of the two has high predictive value for PHN, and has certain clinical reference value.

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备注/Memo

备注/Memo:
基金项目：四川省卫生健康委员会科研课题(19PJ015)。
作者简介：许凤婷（1990-），女，本科，主治医师，研究方向：带状疱疹，E-maill：x02tbo@163.com。
更新日期/Last Update: 2025-01-15