[1]黄春明,潘 鑫,朱玺华.精神分裂症患者血清Zonulin和Claudin-5表达水平与临床精神症状严重程度的相关性研究[J].现代检验医学杂志,2025,40(01):90-93+104.[doi:10.3969/j.issn.1671-7414.2025.01.017]
　HUANG Chunming,PAN Xin,ZHU Xihua.Study on the Serum Expression Levels of Zonulin and Claudin-5 and Their Correlation with the Severity of Clinical Psychiatric Symptoms in Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2025,40(01):90-93+104.[doi:10.3969/j.issn.1671-7414.2025.01.017]
点击复制

精神分裂症患者血清Zonulin和Claudin-5表达水平与临床精神症状严重程度的相关性研究()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年01期
页码:
90-93+104
栏目:
论著
出版日期:
2025-01-15

文章信息/Info

Title:
Study on the Serum Expression Levels of Zonulin and Claudin-5 and Their Correlation with the Severity of Clinical Psychiatric Symptoms in Patients with Schizophrenia
文章编号:
1671-7414（2025）01-090-05
作者:
黄春明; 潘 鑫; 朱玺华
（黑龙江省第三医院精神科重症监护病房，黑龙江北安 164000）
Author(s):
HUANG Chunming; PAN Xin; ZHU Xihua
(Psychiatric Intensive Care Unit，the Third Hospital of Heilongjiang Province，Heilongjiang Bei’an 164000，China)
关键词:
精神分裂症; 连蛋白; 紧密连接蛋白5; 精神症状
分类号:
R749.3；R446.61
DOI:
10.3969/j.issn.1671-7414.2025.01.017
文献标志码:
A
摘要:
目的 探讨精神分裂症（SZ）患者血清连蛋白（Zonulin）、紧密连接蛋白5（Claudin-5）表达水平与精神症状严重程度的关系。方法 选择2019 年4 月～ 2022 年4 月于黑龙江省第三医院确诊的98 例SZ 患者为SZ 组，以50例体检的健康人为对照组。采用酶联免疫吸附实验（ELISA）检测血清Zonulin，Claudin-5 水平。采用Pearson 相关分析血清Zonulin，Claudin-5 与SZ 患者临床指标的关系；Logistic 回归分析SZ 发生的影响因素；采用受试者工作特征（ROC）曲线分析血清Zonulin，Claudin-5 对SZ 的诊断价值。结果 SZ 组血清Zonulin 水平（7.91±0.52μg/L）高于对照组（2.31±0.24 μg/L），血清Claudin-5 水平（12.17±2.34 ng/L）低于对照组（26.78±5.15ng/L），差异具有统计学意义(t=72.235，23.740，均P<0.05)。阳性和阴性症状量表（PANSS）评分总分、阳性和阴性症状评分、一般精神病理学症状评分与血清Zonulin 呈正相关（r=0.660 ～ 0.720，均P ＜ 0.05），与血清Claudin-5 水平呈负相关（r=-0.720 ～ -0.622，均P ＜ 0.05）。血清Zonulin 水平、PANSS 评分总分、阳性症状评分、一般精神病理学症状评分是影响SZ 发生的危险因素，Claudin-5是保护因素（均P ＜ 0.05）。血清Zonulin，Claudin-5 联合诊断SZ 的AUC（95%CI）为0.932(0.891 ～ 0.959)，高于血清Zonulin，Claudin-5 单项诊断的0.814(0.779 ～ 0.847)，0.846(0.811 ～ 0.882)，差异具有统计学意义(Z=5.145，4.210，均P<0.001)。结论 SZ 患者血清Zonulin 水平升高和Claudin-5 水平降低与SZ 患者精神症状的程度有关，血清Zonulin和Claudin-5 联合检测对SZ 具有较高的诊断价值。
Abstract:
Objective To investigate serum levels of Zonulin and Claudin-5 in patients with schizophrenia (SZ) and their relationship with the severity of psychiatric symptoms. Methods 98 patients with SZ treated in the Third Hospital of Heilongjiang Province form April 2019 to April 2022 were selected as the SZ group, and 50 healthy people who underwent physical examination were selected as the control group. Enzyme-linked immunosorbent assay was used to detect serum levels of Zonulin and Claudin-5. Pearson correlation analysis was used to analyze the relationship between serum Zonulin and Claudin-5 levels and clinical parameters in patients with SZ. Logistic regression was used to analyze the risk factors for SZ. Receiver operating characteristic curve was used to analyze the diagnostic value of serum Zonulin and Claudin-5 for SZ. Results The serum level of Zonulin in SZ group（7.91±0.52μg/L）was higher than that in control group (2.31±0.24μg/L), and the serum level of Claudin-5(12.17±2.34ng/L）was lower than that in control group（26.78±5.15 ng/L)，the differences were statistically significant (t=72.235，23.740，all P<0.05).The total scores of Positive and Negative Symptom Scale (PANSS) score, positive and negative symptom scores, general psychiatric symptom scores was positively correlated with serum Zonulin (r = 0.660 ～ 0.720，all P < 0.05), and negatively correlated with serum Claudin - 5 (r= -0.720 ~ -0.622，all P < 0.05).Serum Zonulin , PANSS total score, positive symptom score and general psychopathology symptom score were risk factors for SZ, and Claudin-5 was a protective factor (all P < 0.05).The AUC（95%CI）of serum Zonulin and Claudin-5 combined for SZ diagnosis was 0.932(0.891 ～ 0.959)，which was higher than that of serum Zonulin and Claudin-5 single diagnosis were 0.814(0.779 ～ 0.847)，0.846(0.811 ～ 0.882)，respectively, and the differences were statistically significant (Z=5.145, 4.210, all P<0.05). Conclusion The increase in serum Zonulin levels and the decrease in Claudin-5 levels in SZ patients are related to the severity of their mental symptoms. The combined detection of serum Zonulin and Claudin-5 has high diagnostic value for SZ.

参考文献/References:

[1] JAUHAR S, JOHNSTONE M, MCKENNA P J. Schizophrenia [J]. Lancet(London,England), 2022,399(10323):473-486.
[2] SAFIRI S, KOLAHI A A, CROSS M, et al. Prevalence, incidence, and years lived with disability due to gout and its attributable risk factors for 195 countries and territories 1990-2017: a systematic analysis of the global burden of disease study 2017 [J]. Arthritis Rheumatology, 2020, 72(11): 1916-1927.
[3] TANIR Y, CAHID ?RENG?L A, ESAD ?ZDEMIR Y,transfer of plasma membrane ATP5B and TFR2 to mitochondria triggers hepatic insulin resistance under PFOS exposure [J]. Ecotoxicology and Environmental Safety, 2023, 253: 114662.
[13] L? Tingting, XIONG Xiaofeng, YAN Wei, et al. Mitochondrial general control of amino acid synthesis 5 like 1 promotes nonalcoholic steatohepatitis development through ferroptosis-induced formation of neutrophil extracellular traps[J]. Clinical and Translational Medicine, 2023, 13(7): e1325.
[14] LI Ya’nan, LI Shujing, WU Huijian. Ubiquitinationproteasome system (UPS) and autophagy two main protein degradation machineries in response to cell stress[J]. Cells, 2022, 11(5): 851.
[15] SUN Lin, PAN Xiaomin, WADA Jun, et al. Withdrawal: isolation and functional analysis of mouse UBA52 gene and its relevance to diabetic nephropathy[J]. Journal of Biological Chemistry, 2019, 294(26): 10382.

相似文献/References:

[1]段侠霞,陈英,沈德华,等.儿童及青少年精神分裂症患者血清同型半胱氨酸、叶酸水平与PANSS评分的关系研究[J].现代检验医学杂志,2019,34(01):104.[doi:10.3969/j.issn.1671-7414.2019.01.027]
　DUAN Xia-xia,CHEN Ying,SHEN De-hua,et al.Correlation Study between Serum Homocysteine，Folic Acid Levels and PANSS Score in Children and Adolescents Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2019,34(01):104.[doi:10.3969/j.issn.1671-7414.2019.01.027]
[2]刘亚平a,唐小伟b,冯旭薇a.精神分裂症患者血清降钙素原表达水平与BPRS 量表值及症状的关系分析[J].现代检验医学杂志,2020,35(02):116.[doi:10.3969 ／ j.issn.1671-7414.2020.02.032]
　LIU Ya-pinga,TANG Xiao-weib,FENG Xu-weia.Analysis of the Relationship between Serum Procalcitonin Expression Leveland BPRS Scale and Symptoms in Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2020,35(01):116.[doi:10.3969 ／ j.issn.1671-7414.2020.02.032]
[3]钱博文,王 皓,钟志延,等.精神分裂症患者血清miR-132-3p 和miR-34a-5p 表达水平与认知功能以及诊断的相关性研究[J].现代检验医学杂志,2023,38(01):33.[doi:10.3969/j.issn.1671-7414.2023.01.007]
　QIAN Bo-wen,WANG Hao,ZHONG Zhi-yan,et al.Correlation Study of Serum miR-132-3p and miR-34a-5p Expression Levels with Cognitive Function and Diagnosis in Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2023,38(01):33.[doi:10.3969/j.issn.1671-7414.2023.01.007]
[4]桂 秀,陶璃娜,乔 娟,等.精神分裂症患者血清P2X7R和CTGF水平表达与临床症状评分及认知功能的相关性研究[J].现代检验医学杂志,2024,39(01):61.[doi:10.3969/j.issn.1671-7414.2024.01.011]
　GUI Xiu,TAO Lina,QIAO Juan,et al.Correlation between the Expression of Serum P2X7R and CTGF Levels and Clinical Symptom Scores and Cognitive Function in Patients with Schizophrenia[J].Journal of Modern Laboratory Medicine,2024,39(01):61.[doi:10.3969/j.issn.1671-7414.2024.01.011]

备注/Memo

备注/Memo:
基金项目：黑龙江省卫生健康委科研课题（2019570）。
作者简介：黄春明（1986-），男，本科，主治医师，研究方向：精神疾病诊治，E-mail：huangchunming2580@163.com。
更新日期/Last Update: 2025-01-15