[1]俞 娟,黄 琦,张 亮,等.急性脑梗死患者血清SLC7A11和ACSL4表达水平与神经功能损害程度及预后的关系研究[J].现代检验医学杂志,2025,40(01):153-157.[doi:10.3969/j.issn.1671-7414.2025.01.029]
　YU Juan,HUANG Qi,ZHANG Liang,et al.Study on the Relationship between the Expression Levels of Serum SLC7A11 and ACSL4 and the Degree of Neurological Impairment and Prognosis in Patients with Acute Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2025,40(01):153-157.[doi:10.3969/j.issn.1671-7414.2025.01.029]
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急性脑梗死患者血清SLC7A11和ACSL4表达水平与神经功能损害程度及预后的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年01期
页码:
153-157
栏目:
论著
出版日期:
2025-01-15

文章信息/Info

Title:
Study on the Relationship between the Expression Levels of Serum SLC7A11 and ACSL4 and the Degree of Neurological Impairment and Prognosis in Patients with Acute Cerebral Infarction
文章编号:
1671-7414（2025）01-153-05
作者:
俞 娟; 黄 琦; 张 亮; 沈 慧; 沈李奎
（上海交通大学医学院苏州九龙医院神经内科，江苏苏州215028）
Author(s):
YU Juan; HUANG Qi; ZHANG Liang; SHEN Hui; SHEN Likui
（Department of Neurology，Suzhou Jiulong Hospital，School of Medicine, Shanghai Jiaotong University，Jiangsu Suzhou 215028，China）
关键词:
急性脑梗死; 溶质载体家族7 成员11; 酰基辅酶A 合成酶长链家族成员4; 神经功能损害
分类号:
R743.33；R392.11
DOI:
10.3969/j.issn.1671-7414.2025.01.029
文献标志码:
A
摘要:
目的 探讨急性脑梗死（ACI）患者血清溶质载体家族7 成员11（SLC7A11）和酰基辅酶A 合成酶长链家族成员4（ACSL4）表达与神经功能损害程度及预后的关系。方法 将2019 年10 月～ 2022 年12 月上海交通大学医学院苏州九龙医院神经内科收治的60 例ACI 患者记为ACI 组，将同期体检的60 例健康者作为对照组；采用酶联免疫吸附法（ELISA）检测两组受试者血清SLC7A11 和ACSL4 水平。根据患者神经功能损害程度［美国国立卫生研究院卒中量表（NIHSS）评估］将60 例ACI 患者分为轻症组（n=41）和重症组（n=19），根据患者出院三个月后的预后情况［采用改良Rankin 量表(mRS) 评分评估］将60 例ACI 患者分为良好组（n=47）和不良组（n=13），比较不同组别ACI 患者血清SLC7A11 和ACSL4 水平。采用Pearson 相关性分析血清SLC7A11，ACSL4 水平与神经功能损害程度和预后的相关性；受试者工作特征（ROC）曲线分析血清SLC7A11，ACSL4 及两者联合对ACI 患者预后不良的预测价值。结果 ACI 组血清SLC7A11 水平（16.88±3.19 ng/ml）低于对照组（25.13±5.61 ng/ml），ACSL4 水平（40.01±4.23 ng/ml）高于对照组（23.29±5.72 ng/ml），差异具有统计学意义（t=9.902，18.205，均P<0.05）。重症组ACI 患者血清SLC7A11 水平（15.16±3.91 ng/ml）低于轻症组（17.68±2.41 ng/ml），ACSL4（42.08±5.02 ng/ml）水平高于轻症组（39.05±3.40 ng/ml），不良组ACI 患者血清SLC7A11 水平（14.25±2.95 ng/ml）低于良好组（17.61±2.85 ng/ml），ACSL4 水平（43.54±3.87 ng/ml）高于良好组（39.03±3.78 ng/ml），差异具有统计学意义（t=3.070，2.747；3.735，3.789，均P<0.05）。Pearson 相关性分析显示，血清SLC7A11 水平与ACI 患者NISS 及mRS 评分均呈负相关（r=-0.416，-0.378，均P<0.05），而血清ACSL4 水平与NISS 及mRS 评分均呈正相关（r=0.351，0.415，均P<0.05）。血清SLC7A11 和ACSL4 两者联合预测ACI 患者预后不良的AUC（95%CI）为0.810（0.688~0.900），敏感度和特异度分别为68.09%，92.31%，优于各自单独检测（Z=2.176，1.974，P=0.030，0.048）。结论 血清SLC7A11 和ACSL4 两者联合对ACI 患者预后不良的预测效能较高。
Abstract:
Objective To investigate the relationship between the expression of serum solute carrier family member 11 (SLC7A11) and acyl CoA synthase long-chain family member 4 (ACSL4) and the degree of neurological impairment and prognosis in patients with acute cerebral infarction (ACI). Methods 60 ACI patients admitted to the Department of Neurology, Suzhou Jiulong Hospital, School of Medicine，Shanghai Jiaotong University from October 2019 to December 2022 were selected as the ACI group, and 60 healthy people in the same period were taken as a control group. Serum SLC7A11 and ACSL4 levels were detected by enzyme-linked immunosorbent assay(ELISA). According to the degree of neurological impairment [assessed by the National Institutes of Health Stroke Scale (NIHSS)], 60 patients with ACI were divided into a mild grou（p n=41） and a severe group（ n=19）. According to the prognosis of patients 3 months after discharge [assessed by the modified Rankin scale (mRS) score], 60 patients with ACI were divided into good group（n=47） and bad group（n=13）, and the serum SLC7A11 and ACSL4 levels of ACI patients in different groups were compared. Pearson correlation was used to analyze the correlation between serum SLC7A11 and ACSL4 levels and the degree of neurological impairment and prognosis, and receiver operating characteristic(ROC) curve was used to analyze the value of serum SLC7A11 and ACSL4 levels in predicting poor prognosis of ACI patients．Results The serum SLC7A11 (16.88 ± 3.19ng/ml）level in ACI group was lower than that in the control group（25.13 ± 5.61ng/ml)， and the ACSL4(40.01 ± 4.23ng/ml）level was higher than that in the control group（23.29 ± 5.72ng/ml), with statistical significance (t=9.902，18.205，all P<0.05)．Serum SLC7A11(15.16 ± 3.91ng/ml）level in ACI patients in the severe group was lower than that in the mild group（17.68 ± 2.41ng/ml)，and ACSL4 (42.08 ± 5.02ng/ml） level was higher than that in a mild group（39.05 ± 3.40ng/ml)，the serum SLC7A11(14.25 ± 2.95 ng/ml）level of ACI patients in the bad group was lower than that in the good group（17.61 ± 2.85 ng/ml)，and the ACSL4 (43.54 ± 3.87 ng/ml）level was higher than that in the good group（39.03 ± 3.78 ng/ml)，and the differences were statistical significance (t= 3.070, 2.747；3.735, 3.789, all P<0.05). Pearson correlation analysis showed that serum SLC7A11 level was negatively correlated with NISS and mRS scores of ACI patients (r=-0.416，-0.378，all P < 0.05). The serum ACSL4 level was positively correlated with NISS and mRS scores (r=0.351， 0.415，all P<0.05). The AUC (95% CI) of serum SLC7A11 and ACSL4 in predicting the poor prognosis of ACI patients was 0.810 (0.688 ～ 0.900), and the sensitivity and specificity were 68.09% and 92.31%, respectively, which were better than those of individual detection (Z=2.176，1.977，P=0.030，0.048). Conclusion The combination of serum SLC7A11 and ACSL4 has a high predictive efficiency for the poor prognosis of ACI patients.

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备注/Memo

备注/Memo:
基金项目：江苏省医院协会医院管理创新研究课题（JSYGY-3-2021-455）。
作者简介：俞娟（1979-），女，硕士，副主任医师，研究方向：脑血管病及癫痫，E-mail：you0768684@163.com。
通讯作者：沈慧（1980-），女，硕士研究生，副主任医师，研究方向：脑血管病及神经内科重症感染相关性疾病，E-mail：shenhui0504@sina.com。
更新日期/Last Update: 2025-01-15