[1]王 嘉,朱志国,秦凤玲.糖尿病足患者血清PlGF，TREM1水平检测与临床分级和预后的相关性分析[J].现代检验医学杂志,2025,40(01):163-168.[doi:10.3969/j.issn.1671-7414.2025.01.031]
　WANG Jia,ZHU Zhiguo,QIN Fengling.Correlation Analysis of Serum PlGF, TREM1 Levels with Clinical Grading and Prognosis in Patients with Diabetes Foot[J].Journal of Modern Laboratory Medicine,2025,40(01):163-168.[doi:10.3969/j.issn.1671-7414.2025.01.031]
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糖尿病足患者血清PlGF，TREM1水平检测与临床分级和预后的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年01期
页码:
163-168
栏目:
论著
出版日期:
2025-01-15

文章信息/Info

Title:
Correlation Analysis of Serum PlGF, TREM1 Levels with Clinical Grading and Prognosis in Patients with Diabetes Foot
文章编号:
1671-7414（2025）01-163-06
作者:
王 嘉1; 朱志国2; 秦凤玲1
（1．桂林医学院附属医院内分泌科，广西桂林541000；2．桂林医学院第二附属医院肿瘤科，广西桂林541100）
Author(s):
WANG Jia1; ZHU Zhiguo2; QIN Fengling1
（1．Department of Endocrinology，Affiliated Hospital of Guilin Medical University，Guangxi Guilin 541000，China；2．Department of Oncology，the Second Affiliated Hospital of Guilin Medical University，Guangxi Guilin 541100，China）
关键词:
糖尿病足病; 胎盘生长因子; 髓系细胞表达触发受体1
分类号:
R587.2；R392.11
DOI:
10.3969/j.issn.1671-7414.2025.01.031
文献标志码:
A
摘要:
目的 探究糖尿病足患者血清胎盘生长因子（PlGF）、髓系细胞表达触发受体1（TREM1）水平及二者与患者临床分级和预后的相关性。方法 收集2021 年1 月～ 2023 年1 月桂林医学院附属医院收治的97 例糖尿病足患者作为研究对象（糖尿病足组），另选取同期在该院体检的102 例健康者作为健康对照组；糖尿病足患者按照Wanger 分级标准分为0 ～ 1 级（n=33）、2 ～ 3 级（n=39）和4 ～ 5 级（n=25）；糖尿病足患者进行6 个月随访，将其分为预后良好组（n=72）和预后不良组（n=25）；比较各组血清PlGF，TREM1 水平；采用Spearman 相关分析血清PlGF，TREM1 水平与患者临床分级的相关性；Logistic 回归分析糖尿病足患者预后的影响因素；采用受试者工作特征（ROC）曲线分析血清PlGF，TREM1 对糖尿病足患者预后情况的预测效能。结果 糖尿病足组患者血清PlGF 水平显著低于健康对照组（53.86 ± 15.13 pg/ml vs 87.57 ± 18.28 pg/ml），TREM1 水平显著高于健康对照组（279.56 ± 32.25 ng/L vs195.37 ± 26.28 ng/L），差异具有统计学意义（t=14.133，20.232，均P ＜ 0.05）；临床分级为4 ～ 5 级患者血清PlGF表达低于0 ～ 1 级、2 ～ 3 级患者（39.41 ± 13.28 pg/ml vs 66.13 ± 16.30 pg/ml，52.75 ± 15.32 pg/ml），TREM1 表达高于0 ～ 1 级、2 ～ 3 级患者（326.66 ± 35.75 ng/L vs 248.21 ± 29.83 ng/L，275.89 ± 32.06 ng/L），临床分级为2 ～ 3级患者血清PlGF 表达低于0 ～ 1 级患者，TREM1 表达高于0 ～ 1 级患者，差异具有统计学意义（q=4.852 ～ 12.945，均P ＜ 0.05）.Spearman 相关性分析，糖尿病足患者血清PlGF 水平与其临床分级呈现负相关（r=-0.696，P ＜ 0.001），TREM1 水平与其临床分级呈现正相关（r=0.657，P ＜ 0.001）。多因素Logistic 回归分析，PlGF 是影响糖尿病足患者预后的独立保护因素[OR（95%CI）：0.725（0.531 ～ 0.990）]，TREM1 是独立危险因素[OR（95%CI）：2.308（1.284 ～ 4.147）]；PlGF，TREM1 水平和二者联合预测糖尿病足患者预后情况的AUC（95%CI）分别为0.898（0.820 ～ 0.950），0.817（0.725 ～ 0.888）和0.949（0.885 ～ 0.984），二者联合预测临床效能优于血清PlGF，TREM1 单独预测（Z=2.150， 2.713，P=0.032，0.007）。结论 糖尿病足患者血清PlGF 表达降低，TREM1 表达升高，二者与患者临床分级紧密相关，应用二者预测患者预后情况具有较好的临床效能。
Abstract:
Objective To explore the serum placental growth factor (PlGF) and triggering receptors expressed on myeloid cell-1 (TREM1)levels in patients with diabetes foot, and the correlation between them and clinical grading and prognosis of patients. Methods From January 2021 to January 2023, 97 patients with diabetes foot who were admitted to Affiliated Hospital of Guilin Medical University were collected as the study object (diabetes foot group), and 102 healthy people who were examined in the hospital were collected as the healthy control group. The patients with diabetic foot were categorized into 33 cases of grade 0～1, 39 cases of grade 2 ～ 3, and 25 cases of grade 4 ～ 5 according to Wanger grading criteria. Patients with diabetes foot were followed up for 6 months and divided into good prognosis group (n=72) and poor prognosis group (n=25)．Serum PlGF and TREM1 levels were compared between groups. Spearman correlation analysis was applied to explore the correlation between serum PlGF and TREM1 levels and clinical grading in patients, factors influencing the prognosis of patients with diabetic foot was analyzed by Logistic regression . Receiver operating characteristic (ROC) curve was applied to investigate the predictive effect of serum PlGF and TREM1 on the prognosis of patients with diabetes foot. Results The expression level of serum PlGF in the diabetes foot group was lower than that in the healthy control group (53.86 ± 15.13 pg/ml vs 87.57 ± 18.28 pg/ml), and the level of TREM1 was significantly higher than that in the healthy control group (279.56 ± 32.25 ng/L vs 195.37 ± 26.28 ng/L), and the difference was statistically significance (t=14.133，20.232，all P<0.05)．Serum PlGF expression (39.41 ± 13.28 pg/ml vs 66.13 ± 16.30 pg/ml，52.75 ± 15.32 pg/ml) was lower in patients with clinical grades 4 ～ 5 than in patients with grades 0 ～ 1 and 2 ～ 3. TREM1 expression (326.66 ± 35.75 ng/L vs 248.21 ± 29.83 ng/L, 275.89 ± 32.06 ng/L) was higher than in patients with grades 0 ～ 1 and 2 ～ 3. Serum PlGF expression was lower in patients with clinical grades 2 ～ 3 than in patients with grades 0 ～ 1. TREM1 expression was higher than in patients with grades 0 ～ 1, and the differences were statistically significant (q=5.120 ～ 12.945，all P<0.05)．Spearman correlation analysis，the serum PlGF expression level in diabetes foot patients was negatively correlated with their clinical grading (r=-0.696, P<0.001) and the TREM1 expression level was positively correlated with their clinical grading (r=0.657, P<0.001)．Multivariate Logistic regression anaalysis, PlGF was an independent protective factor [OR(95%CI)：0.725(0.531 ～ 0.990)] and TREM1 was an independent risk factor [OR(95%CI)： 2.308(1.284 ～ 4.147)] affecting the prognosis of diabetic foot patients．The AUC(95%CI) of PlGF, TREM1 levels and their combination to predict the prognosis of diabetes foot patients was 0.898（0.820 ～ 0.950），0.817（0.725 ～ 0.888）and 0.949 （0.885 ～ 0.984）, respectively. The clinical efficacy of the combination of the two in predicting the poor prognosis of patients with diabetes foot was better than that of serum PlGF and TREM1 alone (Z =2.150, 2.713, P=0.032, 0.007). Conclusion The expression of PlGF in serum of patients with diabetes foot is significantly reduced, and the expression of TREM1 is significantly increased. Both of them are closely related to the clinical grading of patients, and they have good clinical efficacy in predicting prognosis.

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备注/Memo

备注/Memo:
基金项目：玉林市科学研究与技术开发计划（玉市科20201606）。
作者简介：王嘉（1989-），男，本科，主治医师，研究方向：代谢内分泌，糖尿病足，E-mail：jiem648462@163.com。
更新日期/Last Update: 2025-01-15