[1]吴道雄,李妍锦,王玉明,等.肺动脉高压早期诊断的生物标志物最新研究进展[J].现代检验医学杂志,2025,40(01):208-212.[doi:10.3969/j.issn.1671-7414.2025.01.040]
 WU Daoxiong,LI Yanjin,WANG Yuming,et al.Recent Progress in Biomarkers for the Early Diagnosis of Pulmonary Hypertension[J].Journal of Modern Laboratory Medicine,2025,40(01):208-212.[doi:10.3969/j.issn.1671-7414.2025.01.040]
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肺动脉高压早期诊断的生物标志物最新研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年01期
页码:
208-212
栏目:
综述
出版日期:
2025-01-15

文章信息/Info

Title:
Recent Progress in Biomarkers for the Early Diagnosis of Pulmonary Hypertension
文章编号:
1671-7414(2025)01-208-05
作者:
吴道雄1李妍锦1王玉明1胡 莹1林 娅2马 润1
(1. 昆明医科大学第二附属医院,昆明 650101;2. 云南省阜外心血管病医院,昆明 650102)
Author(s):
WU Daoxiong1LI Yanjin1WANG Yuming1HU Ying1LIN Ya2MA Run1
(1. the Second Affiliated Hospital of Kunming Medical University,Kunming 650101, China;2. Yunnan Fuwai Cardiovascular Hospital, Yunnan Kunming 650102, China)
关键词:
肺动脉高压生物标志物研究进展
分类号:
R543.2;R446
DOI:
10.3969/j.issn.1671-7414.2025.01.040
文献标志码:
A
摘要:
肺动脉高压(PH)是一类以肺血管重塑为特征的进展性疾病,部分患者确诊时已出现右心功能不全。因此,PH 的早期诊断对改善患者生活质量及延长生存期至关重要。生物标志物是疾病早期诊断的一个重要指标,传统的PH诊断的生物标志物有很多,但敏感度和特异度较低。随着研究的进展,一些新的生物标志物被证明可预测早期PH 的疾病进展,对PH 的早期诊断起着重要作用。该文从右心功能不全、内皮功能障碍、肺动脉平滑肌功能障碍、炎症、原位血栓形成等方面对PH 的生物标志物的研究进展进行综述,以期为PH 的早期诊断提供探索方向及参考价值。
Abstract:
Pulmonary hypertension (PH) is a group of progressive diseases characterized by pulmonary vascular remodeling, and some patients already have right heart insufficiency at the time of diagnosis. Therefore, early diagnosis of PH is essential to improve patients’ quality of life and prolong survival. Biomarkers are an important indicator for early diagnosis of the disease, and there are many traditional biomarkers for PH diagnosis, but the sensitivity and specificity are low. With the progress of research, some new biomarkers have been shown to predict disease progression in early PH and play an important role in the early diagnosis of PH. This study reviews the research progress of biomarkers of PH from the aspects of right heart insufficiency, endothelial dysfunction, pulmonary artery smooth muscle dysfunction, inflammation, and in situ thrombosis to provide exploration direction and reference value for early diagnosis of PH.

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备注/Memo

备注/Memo:
基金项目:昆明医科大学研究生创新基金(2024S311);云南省阜外心血管病医院人才托举计划项目(2024RCTJ-QN009)。
作者简介:吴道雄(1995-),男,硕士研究生在读,住院医师,研究方向:临床生物化学,E-mail:1761851741@qq.com。
通讯作者:马润(1980-),女,硕士,副主任技师,研究方向:临床生物化学,E-mail:467161115@qq.com。
更新日期/Last Update: 2025-01-15