[1]刘 仪,赵和平,齐 茜,等.基质金属蛋白酶3在骨骼系统中双重调控作用机制的最新研究进展[J].现代检验医学杂志,2025,40(02):208.[doi:10.3969/j.issn.1671-7414.2025.02.039]
　LIU Yi,ZHAO Heping,QI Xi,et al.Latest Research Progress on Dual Regulatory Mechanisms of Matrix Metalloproteinase 3 in Skeletal System[J].Journal of Modern Laboratory Medicine,2025,40(02):208.[doi:10.3969/j.issn.1671-7414.2025.02.039]
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基质金属蛋白酶3在骨骼系统中双重调控作用机制的最新研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年02期
页码:
208
栏目:
综述
出版日期:
2025-03-15

文章信息/Info

Title:
Latest Research Progress on Dual Regulatory Mechanisms of Matrix Metalloproteinase 3 in Skeletal System
文章编号:
1671-7414（2025）02-208-07
作者:
刘 仪; 赵和平; 齐 茜; 于 燕
（西安交通大学附属红会医院检验科，西安 710054）
Author(s):
LIU Yi; ZHAO Heping;  QI Xi;  YU Yan
（Department of Clinical Laboratory，Honghui Hospital Affiliated to Xi’an Jiaotong University, Xi’an 710054, China）
关键词:
基质金属蛋白酶3; 双重调控作用; 骨关节疾病; 创伤愈合
分类号:
R684；R446.11
DOI:
10.3969/j.issn.1671-7414.2025.02.039
文献标志码:
A
摘要:
随着人口老龄化问题日益严重，类风湿关节炎（RA）、骨关节炎（OA）、强直性脊柱炎（AS）以及骨质疏松症（OP）等骨关节疾病的发病率正在逐步上升。基质金属蛋白酶3（MMP-3）作为基质金属蛋白酶（MMPs）家族中的重要成员，具有双重调控作用。一方面，它参与了软骨损伤和关节功能障碍等病理过程，在多种骨关节疾病的发生和进展中发挥负向调控作用；另一方面，MMP-3 也在早期胚层分化、颌面部骨骼形成、神经元轴突再生、软骨骨化和脂肪细胞分化等方面具有正向调控作用。该文综述了MMP-3 的结构和功能，以及其在RA，OA，AS 和OP 等疾病中的负调控作用，同时探讨了其在生长发育和创伤愈合中的正调控作用。该文还分析了MMP-3 在骨关节疾病中双重调控作用的机制，并总结了MMP-3 抑制剂的研究进展，以期为相关临床研究提供新的思路和见解。
Abstract:
With the increasing problem of an aging population, the incidence of osteoarticular diseases such as rheumatoid arthritis (RA), osteoarthritis (OA), ankylosing spondylitis (AS) and osteoporosis (OP) is gradually rising. Matrix metalloproteinase 3 (MMP-3), as an important member of the matrix metalloproteinases (MMPs) family, plays a dual regulatory role. On one hand, it is involved in pathological processes such as cartilage damage and joint dysfunction, exerting a negative regulatory effect in the occurrence and progression of various osteoarticular diseases. On the other hand, MMP-3 has positive regulatory effects in early embryonic layer differentiation, craniofacial bone formation, neuronal axon regeneration, cartilage ossification, and adipocyte differentiation. This article reviewed the structure and function of MMP-3 as well as its negative regulatory roles in diseases such as in RA, OA, AS and OP, while exploring its positive regulatory roles in growth, development and wound healing. The article also analyzed the dual regulatory mechanisms of MMP-3 in bone and joint diseases, and summarized the research progress of MMP-3 inhibitors, in order to provide new ideas and insights for related clinical research.

参考文献/References:

[1] JEHAN F, ZARKA M, DE LA HOUSSAYE G,et al.New insights into the role of matrix metalloproteinase 3 (MMP3) in bone[J].FASEB BioAdvances,2022, 4(8):524-538.
[2] MANKA S W, BIHAN D, FARNDALE R W. Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling[J]. Scientific reports, 2019, 9(1): 18785.
[3] NAGASE H, WOESSNER J F.Matrix metalloproteinases[J]. the Journal of Biological chemistry, 1999,274(31): 21491-21494.
[4] WAN Jiangtao, ZHANG Guowei, LI Xin, et al. Matrix metalloproteinase 3: a promoting and destabilizing factor in the pathogenesis of disease and cell differentiation[J].Frontiers in physiology, 2021, 12: 663978.
[5] ALMUTAIRI S, KALLOUSH H M, MANOON N A, et al. Matrix metalloproteinases inhibitors in cancer treatment: an updated review (2013-2023)[J].Molecules, 2023, 28(14): 5567.
[6] LERNER A, NEIDH?FER S, REUTER S, et al. MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis[J]. Best Practice & Research. Clinical Rheumatology, 2018, 32(4): 550-562.
[7] 陈红,王小超,陶丽菊.基质金属蛋白酶3 在风湿免疫性疾病诊断?疗效评估中的价值[J].中国老年学杂志,2021,41(12):2565-2567. CHEN Hong, WANG Xiaochao, TAO Liju. The value of matrix metalloproteinase 3 in the diagnosis and efficacy evaluation of rheumatic immune diseases[J]. Chinese Journal of Gerontology, 2021, 41(12): 2565-2567.
[8] TUNCER T, KAYA A, GULKESEN A, et al. Matrix metalloproteinase-3 levels in relation to disease activity and radiological progression in rheumatoid arthritis[J].Advances in Clinical and Experimental Medicine,2019, 28(5): 665-670.
[9] 王鑫.MMP-3 对类风湿关节炎患者的诊断效能及疾病活动度的评估[D]. 沈阳:中国医科大学,2021. Wang Xin. Evaluation of dingnostic efficacy and disease activity of MMP-3 in patients with rheumatoid arthritis [D].Shenyang: China Medical University, 2021.
[10] 王晓亮, 郑伟, 赵娜, 等. 类风湿关节炎患者血清IL-35, MMP-3, Gal-1 水平及其与免疫功能指标的相关性研究[J]. 现代检验医学杂志,2022, 37(2):71-75. WANG Xiaoliang, ZHENG Wei, ZHAO Na, et al. Study on the changes of serum IL-35, MMP-3, Gal-1 levels and their correlation with immune function indexes in patients with rheumatoid arthritis[J]. Journal of Modern Laboratory Medicine, 2022, 37(2): 71-75.
[11] 朱玉光, 方丽佳, 黄素玲. 类风湿关节炎患者关节滑液及滑膜组织中CCP/AST 表达水平及临床意义[J].现代检验医学杂志, 2024,39(1):162-165, 174. ZHU Yuguang, FANG Lijia, HUANG Suling. Expression level of CCP/AST in synovial fluid and synovial tissue of rheumatoid arthritis patients and its clinical significance[J]. Journal of Modern Laboratory Medicine, 2024, 39(1): 162-165, 174.
[12] LIANG Zhaojun, WANG Nan, SHANG Lili, et al. Evaluation of the immune feature of ACPA-negative rheumatoid arthritis and the clinical value of matrix metalloproteinase-3 [J].Frontiers in Immunology, 2022, 13: 939265.
[13] LIU M K, WANG L C, HU F L. Value of serum matrix metalloproteinase 3 in the assessment of early rheumatoid arthritis[J]. Journal of Peking University. Health Sciences, 2018, 50(6): 981-985.
[14] 林薇. 血清MMP-3 在类风湿关节炎中的临床意义及尪痹片对血清MMP-3 的影响[D]. 重庆: 重庆医科大学, 2022. LIN Wei. The Clinical significance of serum MMP-3 in rheumatiod arthritis and the effect of Wangbi tablet on serum MMP-3 [D]. Chongqing: Chongqing Medical University, 2022.
[15] 李恭鹏, 李朋, 张先锋. 血清MMP-3 水平在类风湿性关节滑膜炎诊断及疾病严重程度预测中的应用价值分析[J]. 标记免疫分析与临床,2019,26(6):982-985. LI Gongpeng, LI Peng, ZHANG Xianfeng. The value of serum MMP-3 level in the diagnosis of rheumatic diseases synovitis and the prediction of disease severity[J]. Labeled Immunoassays and Clinical Medicine, 2019, 26(6): 982-985.
[16] 李佳芯. 血清APN, MMP-1, MMP-3 水平检测在类风湿性关节炎患者病情评估中的价值[J]. 中国民康医学,2021, 33(16):92-94. LI Jiaxin. The value of serum APN,MMP-1 and MMP-3 levels in the assessment of disease status in patients with rheumatoid arthritis[J]. Medical Journal of Chinese People’s Health, 2021, 33(16): 92-94.
[17] 杨勇, 陆静芬, 徐军, 等. 基质金属蛋白酶3 在类风湿关节炎不同活动状态中的临床意义[J]. 中华检验医学杂志,2020,43(4):463-467. YANG Yong, LU Jingfen, XU Jun, et al. Clinical significance of matrix metalloproteinase 3 in different active states of rheumatoid arthritis[J]. Chinese Journal of Laboratory Medicine, 2020, 43(4): 463-467.
[18] 戴许阳. 血清25(OH)D_3,MMP-3 水平及自身抗体与类风湿关节炎活动性相关性研究[D]. 新乡: 新乡医学院,2020. DAI Xuyang. Correlation berween serum 25(OH) D3, MMP-3 levels and autoantibodies and rheumatoid arthritis activity [D]. Xinxiang: Xinxiang Medical University, 2020.
[19] 杨平, 张孝山, 陶月, 等. 基质金属蛋白酶3 在类风湿关节炎疗效观察中的临床价值[J].临床检验杂志,2022,40(3):209-212. YANG Ping, ZHANG Xiaoshan, TAO Yue, et al. The clinical value of matrix metalloproteinase 3 in the observation of therapeutic effects in rheumatoid arthritis[J]. Chinese Journal of Clinical Laboratory Science, 2022, 40(3): 209-212.
[20] 朱柏林, 梁丽婷. 血清MMP-3 水平预测类风湿性关节炎MRI 影像学变化的研究[J]. 实验与检验医学,2020,38(6):1085-1088. ZHU Bailin, LIANG Liting. An experimental study on the detection and evaluation of serum MMP-3 in predicting the progress of MR imaging in rheumatoid arthritis[J]. Experimental and Laboratory Medicine,2020, 38(6): 1085-1088.
[21] HATTORI Y, KIDA D, KANEKO A. Normal serum matrix metalloproteinase-3 levels can be used to predict clinical remission and normal physical function in patients with rheumatoid arthritis[J]. Clinical Rheumatology, 2019, 38(1): 181-187.
[22] ZENG Jianjun, WANG Haidong, SHEN Zhongwei,et al. Curcumin inhibits proliferation of synovial cells by downregulating expression of matrix metalloproteinase-3 in osteoarthritis[J]. Orthopaedic Surgery, 2019, 11(1): 117-125.
[23] 白亚平, 王倩, 严亚玲, 等. 原发性膝骨关节炎患者血浆cf-DNA/NETs 的检测水平及临床意义[J]. 现代检验医学杂志,2022,37(5):100-104. BAI Yaping, WANG Qian, YAN Yaling, et al. Detection level and clinical significance of plasma cf-DNA/NETs in patients with primary knee osteoarthritis[J]. Journal of Modern Laboratory Medicine, 2022, 37(5): 100-104.
[24] HAO H Q, ZHANG J F, HE Q Q, et al. Cartilage oligomeric matrix protein, C-terminal crosslinking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip osteoarthritis (OA) diagnosis: a systematic review and meta-analysis[J]. Osteoarthritis and Cartilage, 2019,27(5): 726-736.
[25] LI Yishuo, ZHAO Min, XIAO Weiguo. KLF15 regulates the expression of MMP-3 in human chondrocytes[J]. Journal of Interferon & Cytokine Research, 2018, 38(8): 356-362.
[26] 宋飞, 赵方, 郝峻烽, 等.HIF-2α 和MMP3 在膝骨性关节炎患者血清及滑膜液中的表达及意义[J]. 武警后勤学院学报( 医学版),2021,30(10):110-112, 115. SONG Fei, ZHAO Fang, HAO Junfeng, et al. Expression and significance of HIF-2αand MMP3 in serum and synovial fluid of patients with knee osteoarthritis[J]. Journal of Logistics University of PAP(Medical Sciences), 2021, 30(10): 110-112, 115.
[27] 羊鹏飞.MMP-3 和Galectin-3 在骨性关节炎患者滑膜组织中的表达及临床意义[D]. 石河子: 石河子大学,2019. YANG Pengfei. Expression and Clincal significance of matrix metallo proteinase-3 and galectin-3 in synovial tissue of osteo arthritis [D]. Shihezi: Shihezi University, 2019.
[28] 菅永志, 叶林, 李跃军, 等.β-catenin 和MMP-3 在骨性关节炎软骨组织中的表达及临床意义[J]. 石河子大学学报( 自然科学版),2019,37(6):770-779. JIAN Yongzhi, YE Lin, LI Yuejun, et al. The expression and clinical significance of β-catenin and MMP-3 in cartilage tissue of osteoarthritis[J]. Journal of Shihezi University(Natural Science), 2019, 37(6): 770-779.
[29] 陈家瀚, 李彦奇, 王鑫, 等.MMP-3-1171 基因多态性与新疆地区汉族和维吾尔族骨关节炎的关系[J].石河子大学学报( 自然科学版),2022,40(1):121-126. CHEN Jiahan, LI Yanqi, WANG Xin, et al. Study on relationship between MMP3-1171 polymorphism and osteoarthritis in Han and Uygur nationality in Xinjiang[J]. Journal of Shihezi University(Natural Science), 2022, 40(1): 121-126.
[30] KROON F, BAY-JENSEN A C, WITTOEK R,et al. Etanercept therapy leads to reductions in matrix metalloproteinase-3 in patients with erosive hand osteoarthritis[J]. Scandinavian Journal of Rheumatology, 2020, 49(2): 167-168.
[31] 彭力阳, 陈荣彬, 李勇.MRI 结合血清?关节液中NO,MMP3 水平在膝关节类风湿与骨性关节炎的诊断价值[J]. 中国CT 和MRI 杂志,2020,18(2):138-141. PENG Liyang, CHEN Rongbin, LI Yong. The diagnostic value of MRI combined with serum and fluid levels of NO and MMP3 in the diagnosis of rheumatoid arthritis and osteoarthritis of the knee[J]. Chinese Journal of CT and MRI, 2020, 18(2): 138-141.
[32] ZHU Yong, LI Shunan, HUANG Zhi, et al. Association study between matrix metalloproteinase-3 gene(MMP3) polymorphisms and ankylosing spondylitis susceptibility[J]. Molecular Genetics & Genomic Medicine, 2019, 7(7): e00752.
[33] 马小娟, 冯振宇, 孟霜, 等. 风湿宁胶囊对RA 兔关节滑膜组织MMP-3,MMP-9 表达的影响[J]. 世界中西医结合杂志,2019,14(7):941-945,982. MA Xiaojuan,FENG Zhenyu,MENG Shuang,et al.Effect of fengshining capsules on the expressions of MMP -3 and MMP -9 in joint synovial tissue of the rabbits with rheumatoid arthritis[J].World Journal of Integrated Traditional and Western Medicine,2019,14(7):941-945,982.
[34] YU Zeyun, WANG Yingni, LI Yuan, et al. Effect of moxibustion on the serum levels of MMP-1, MMP-3, and VEGF in patients with rheumatoid arthritis[J].Evidence-based Complementary and Alternative Medicine , 2020, 2020: 7150605.
[35] SOLIMAN E, LABIB W, EL-TANTAWI G, et al. Role of matrix metalloproteinase-3 (MMP-3) and magnetic resonance imaging of sacroiliitis in assessing disease activity in ankylosing spondylitis[J]. Rheumatology International, 2012, 32(6): 1711-1720.
[36] 刘小莉, 张红梅, 唐敏, 等. 不同疾病分期强直性脊柱炎患者外周血DKK-1,MMP-3,TNF-α 和IL-6 的表达及治疗前后水平变化[J]. 现代免疫学,2020,40(4):300-305. LIU Xiaoli, ZHANG Hong-mei, TANG Min, et al. The expression of DKK-1, MMP-3, TNF-α and IL-6 in peripheral blood of ankylosing spondylitis patients with different disease stages and the changes before and after treatment[J]. Current Immunology, 2020, 40(4): 300-305.
[37] 周锐志, 李彦磊, 钟鑫, 等. 强直性脊柱炎患者MRI表现与血清MMP-3,TNF-α 水平的关系[J]. 中国CT 和MRI 杂志,2022,20(3):168-170. ZHOU Ruizhi, LI Yanlei, ZHONG Xin, et al. Relationship between MRI findings of sacroiliac joints in ankylosing spondylitis and serum MMP-3 and TNF-α levels[J]. Chinese Journal of CT and MRI,2022, 20(3): 168-170.
[38] 曹俊杰, 罗改莹, 王瑞. 外周血C- 反应蛋白与清蛋白比值及红细胞分布宽度检测对强直性脊柱炎的诊断价值[J]. 现代检验医学杂志,2021,36(6):136-138, 196. CAO Junjie, LUO Gaiying, WANG Rui. Clinical value of peripheral blood c-reactive protein to albumin ratio and red blood cell distribution width in diagnosis of ankylosing spondylitis[J]. Journal of Modern Laboratory Medicine, 2021, 36(6): 136-138, 196.
[39] WEI J C C, LEE H S, CHEN W C, et al. Genetic polymorphisms of the matrix metalloproteinase-3(MMP- 3 ) a n d t i s s u e i n h i b i t o r s o f m a t r i x metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis[J]. Annals of the Rheumatic Diseases, 2009, 68(11): 1781-1786.
[40] 林宁, 林新, 邓之奎. 强直性脊柱炎患者血清基质金属蛋白酶-3,TNF-α,IL-15,CRP 水平及意义的研究[J]. 现代检验医学杂志,2007,22(5):55-57. LIN Ning, LIN Xin, DENG Zhikui. Significance of serum matrix metalloproteinase-3,TNF-α,IL-15 and CRP level in patients with ankylosing spondylitis[J]. Journal of Modern Laboratory Medicine, 2007, 22(5): 55-57.
[41] 许苏琴, 金月丹, 王智敏, 等.MMP-3 和SAA 联合检测在强直性脊柱炎患者疾病活动度中的应用[J].现代实用医学,2021,33(3):361-362. XU Suqin, JIN Yuedan, WANG Zhimin, et al. The combined detection of MMP-3 and SAA in the assessment of disease activity in patients with ankylosing spondylitis[J]. Modern Practical Medicine, 2021, 33(3): 361-362.
[42] XIE Yangzhouyun, LIN Tonghui, JIN Ying, et al. Smooth muscle cell-specific matrix metallo proteinase-3 deletion reduces osteogenic transformation and medial artery calcification[J].Cardiovascular Research,2024,120(6):658-670.
[43] WANG Yong, LI Hongbin, WANG Jing, et al. Associations of changes in serum inflammatory factors,MMP-3, 25(OH)D and intestinal flora with osteoporosis and disease activity in rheumatoid arthritis patients[J].Clinical Laboratory, 2020, 66(12): 200242.
[44] KODAMA R, MURAKI S, IIDAKA T, et al. Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study[J]. Journal of Bone and Mineral Metabolism, 2018, 36(2): 246-253.
[45] MALAISE O, RELIC B, QUESADA-CALVO F, et al. Selective glucocorticoid receptor modulator compound A,in contrast to prednisolone,does not induce leptin or the leptin receptor in human osteoarthritis synovial fibroblasts[J].Rheumatology (Oxford, England), 2015, 54(6): 1087-1092.
[46] SHI Bohui, GUO Xiong, IV Ai1i, et al. Correction to: Polymorphism of MMP-3 gene and imbalance expression of MMP-3 / TIMP-1 in articular cartilage are associated with an endemic osteochondropathy, Kashin- Beck disease[J]. BMC Musculoskeletal Disorders, 2022, 23(1): 148.
[47] CHIBA D, TSUDA E, SASAKI E, et al. Low prevalence of knee chondrocalcinosis and its catabolic association with serum matrix metalloproteinase 3:A rural Japanese population study[J]. International Journal of Rheumatic Diseases, 2018, 21(11): 2011-2018.
[48] CABRAL-PACHECO G A, GARZA-VELOZ I,CASTRUITA-DE LA ROSA C, et al. The roles of matrix metalloproteinases and their inhibitors in human diseases[J]. International Journal of Molecular Sciences, 2020, 21(24): 9739.
[49] HUTH S, HUTH L, MARQUARDT Y, et al. MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment[J].Lasers in Medical Science, 2022, 37(2): 887-894.
[50] BLUMENFELD I, SROUJI S, PELED M, et al. Metalloproteinases (MMPs -2, -3) are involved in TGF-beta and IGF-1-induced bone defect healing in 20-month-old female rats[J]. Archives of Gerontology and Geriatrics, 2002, 35(1): 59-69.
[51] KHOSWANTO C. Role of matrix metalloproteinases in bone regeneration: narrative review[J]. Journal of Oral Biology and Craniofacial Research, 2023, 13(5): 539-543.
[52] FERNANDES J C, MARTEL-PELLETIER J,PELLETIER J P. The role of cytokines in osteoarthritis pathophysiology[J]. Biorheology, 2002, 39(1/2): 237-246.
[53] WANG Qin, DELCORDE J, TANG T, et al. Regulation of IL-1 signaling through control of focal adhesion assembly[J]. FASEB Journal, 2018, 32(6): 3119-3132.
[54] HOSAKA K, RYU J, SAITOH S, et al. The combined effects of anti-TNF alpha antibody and IL-1 receptor antagonist in human rheumatoid arthritis synovial membrane[J]. Cytokine, 2005, 32(6): 263-269.
[55] LIU Yu, LIN Jiayi, WU Xiexing, et al. Aspirinmediated attenuation of intervertebral disc degeneration by ameliorating reactive oxygen species in vivo and in vitro[J]. Oxidative Medicine and Cellular Longevity,2019, 2019: 7189854.
[56] CHANG Shunfu, YEH C C, CHEN P J, et al. The impact of lipid types and liposomal formulations on osteoblast adiposity and mineralization[J]. Molecules, 2018, 23(1): 95.
[57] MACIAS D, GA?AN Y, SAMPATH T K, et al. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development[J].Development, 1997, 124(6): 1109-1117.
[58] GAO J B, LIN L, MEN X Q, et al. Fibulin-5 protects the extracellular matrix of chondrocytes by inhibiting the Wnt/β-catenin signaling pathway and relieves osteoarthritis[J]. European Review for Medical and Pharmacological Sciences, 2020, 24(10): 5249-5258.
[59] KATO N, KOBAYASHI T, HONDA H. Screening of stress enhancer based on analysis of gene expression profiles: enhancement of hyperthermia-induced tumor necrosis by an MMP-3 inhibitor[J]. Cancer Science, 2003, 94(7): 644-649.
[60] CLOSE D R. Matrix metalloproteinase inhibitors in rheumatic diseases[J]. Annals of the Rheumatic Diseases, 2001, 60 (Suppl 3): iii62-iii67.
[61] KRZESKI P, BUCKLAND-WRIGHT C, B?LINT G,et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind,placebo-controlled study[J]. Arthritis Research and Therapy, 2007, 9(5): R109.

相似文献/References:

[1]王晓亮,郑　伟,赵　娜,等.类风湿关节炎患者血清IL-35，MMP-3，Gal-1水平及其与免疫功能指标的相关性研究[J].现代检验医学杂志,2022,37(02):71.[doi:10.3969/j.issn.1671-7414.2022.02.015]
　WANG Xiao-liang,ZHENG Wei,ZHAO Na,et al.Study on the Changes of Serum IL-35, MMP-3, Gal-1 Levels and Their Correlation with Immune Function Indexes in Patients with Rheumatoid Arthritis[J].Journal of Modern Laboratory Medicine,2022,37(02):71.[doi:10.3969/j.issn.1671-7414.2022.02.015]

备注/Memo

备注/Memo:
作者简介：刘仪（1991-），男，硕士，主管检验师，研究方向：感染免疫，E-mail：1084241765@qq.com。
通讯作者：于燕（1974-），女，硕士，主任技师，主要从事病原微生物学研究，E-mail：732867304@qq.com。
更新日期/Last Update: 2025-03-15