[1]史 健,熊朝亮,雷 静,等.脓毒血症早期诊断血清学标志物及预测模型研究进展[J].现代检验医学杂志,2025,40(02):214-220.[doi:10.3969/j.issn.1671-7414.2025.02.040]
　SHI Jian,XIONG Chaoliang,LEI Jing,et al.Research Progress on Serological Markers and Prediction Models for Early Diagnosis of Sepsis[J].Journal of Modern Laboratory Medicine,2025,40(02):214-220.[doi:10.3969/j.issn.1671-7414.2025.02.040]
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脓毒血症早期诊断血清学标志物及预测模型研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年02期
页码:
214-220
栏目:
综述
出版日期:
2025-03-15

文章信息/Info

Title:
Research Progress on Serological Markers and Prediction Models for Early Diagnosis of Sepsis
文章编号:
1671-7414（2025）02-214-07
作者:
史 健1; 熊朝亮2; 雷 静2; 刘泽世2; 耿 燕1; 2
（1. 陕西中医药大学医学技术学院，陕西咸阳 712000；2. 西安交通大学第二附属医院检验科，西安 710004）
Author(s):
SHI Jian1 ;  XIONG Chaoliang2 ;  LEI Jing2 ;  LIU Zeshi2 ;  GENG Yan1; 2
(1.College of Medical Technology, Shaanxi University of Chinese Medicine, Shaanxi Xianyang 712000, China; 2.Department of Clinical Laboratory, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China)
关键词:
脓毒血症; 血清学标志物; 感染; 诊断; 预测模型
分类号:
R631；R446
DOI:
10.3969/j.issn.1671-7414.2025.02.040
文献标志码:
A
摘要:
脓毒血症是危重患者死亡的主要原因，早期识别感染类型是决定患者治疗和预后的关键。目前，血培养作为脓毒血症诊断的金标准，但因其培养周期长且阳性率较低等局限性，而无法为临床早期开展抗感染治疗提供病原学依据。血清学标志物因其在体外检测方便快捷，且可作为早期推断感染的有益实验室指标而受到广泛关注。近年来，随着各领域对脓毒血症的深入研究，许多新型血清学标志物被发现在诊断脓毒血症方面具有潜在应用价值。因此，该文就近年研究报道的脓毒血症的新型血清学标志物的特点及应用价值进行探讨，以期发现有价值的早期诊断脓毒血症的新型血清学标志物，并结合相关预测模型进行综述，为临床早期诊断脓毒血症带来新思路。
Abstract:
Sepsis constitutes a predominant cause of mortality in critically ill patients, and early determination of the type of infection is crucial for influencing patient management and forecasting outcomes. Currently, blood culture serves as the gold standard for diagnosing sepsis. Yet, its limitations, such as a lengthy culture period and low positivity rate, hinder its ability to provide a microbiological basis for early initiation of antimicrobial therapy in clinical practice. Serological markers have engendered significant interest due to their convenience and rapid detection in vitro, emerging as indispensable laboratory indices for early inference of infection. In recent years, with extensive research on sepsis across diverse academic domains, numerous novel serological markers exhibit promise in diagnosing sepsis. Therefore, this review explores the characteristics and applicatron value of new serological markers for early diagnosis of sepsis, and reviews them in combination with relevant predictive models, bringing new ideas for early clinical diagnosis of sepsis.

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备注/Memo

备注/Memo:
作者简介：史健（1997-），男，硕士研究生在读，主要研究方向：感染性疾病的实验室分子诊断，E-mail：1367846347@qq.com。
通讯作者：耿燕（1967-），女，博士，二级主任技师，硕士生导师，主要从事感染性疾病诊断与细菌耐药。
更新日期/Last Update: 2025-03-15