[1]李家明,李佳鑫,李欣霏,等.四川省攀枝花地区学龄前期3～6岁健康儿童静脉全血红细胞及相关参数参考区间的建立[J].现代检验医学杂志,2025,40(05):167-171.[doi:10.3969/j.issn.1671-7414.2025.05.032]
　LI Jiaming,LI Jiaxin,LI Xinfei,et al.Establishment of Reference Intervals for Venous Whole Blood Red Cell and Related Parameters in Healthy Children Preschool Stage 3~6 Years in Panzhihua, Sichuan Province[J].Journal of Modern Laboratory Medicine,2025,40(05):167-171.[doi:10.3969/j.issn.1671-7414.2025.05.032]
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四川省攀枝花地区学龄前期3～6岁健康儿童静脉全血红细胞及相关参数参考区间的建立()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年05期
页码:
167-171
栏目:
论著
出版日期:
2025-09-15

文章信息/Info

Title:
Establishment of Reference Intervals for Venous Whole Blood Red Cell and Related Parameters in Healthy Children Preschool Stage 3~6 Years in Panzhihua, Sichuan Province
文章编号:
1671-7414（2025）05-167-05
作者:
李家明1，李佳鑫1，李欣霏2，杨雯翔1，李婷婷3，黄付林1
1.攀钢集团总医院检验科，四川攀枝花 617000;2.成都艾迪康医学检测公司，成都 610036;3.四川大家医学检测有限公司，成都 610097
Author(s):
LI Jiaming1，LI Jiaxin1，LI Xinfei2，YANG Wenxiang1，LI Tingting3，HUANG Fulin1
1.Department of Clinical Laboratory，Panzhihua General Hospital，Sichuan Panzhihua 617000, China;2.Chengdu Adicon Medical Testing Company, Chengdu 610036, China;3.Sichuan Dajia Medical Testing Co. Ltd, Chengdu 610097, China
关键词:
参考区间; 健康儿童; 静脉全血; 红细胞; 红细胞体积分布宽度
分类号:
R446.113
DOI:
10.3969/j.issn.1671-7414.2025.05.032
文献标志码:
A
摘要:
目的建立攀枝花地区学龄前期3～6岁健康儿童静脉全血红细胞及相关参数的参考区间，为儿科临床诊疗提供切合实际的实验依据。方法收集2023年1～7月攀枝花地区3～6岁入托体检符合条件的健康儿童1467例为研究对象，其中男童762例，女童705例。采用SysmexXN-1000全自动血液分析仪检测红细胞（RBC）、血红蛋白(Hb)、红细胞比容(HCT)、平均红细胞容积（MCV）、平均红细胞血红蛋白含量（MCH）、平均红细胞血红蛋白浓度（MCHC）和红细胞体积分布宽度（RDW）。按性别和年龄分组，比较不同性别、年龄分组间上述指标的差异，建立攀枝花地区学龄前3～6岁健康儿童静脉全血红细胞及相关参数的参考区间。同时选择25例（其中男童13例,女童12例）样本验证新建立的参考区间。结果攀枝花地区学龄前期3～6岁儿童HCT，RDW-SD参考区间，男童女童之间比较差异无统计学意义（U=0.000，0.795，均P＞0.05）；而RBC，MCV，MCH，RDW-CV的参考区间男孩与女孩间差异具有统计学意义（U=2.829～5.753，均P＜0.05）。Hb，MCHC参考区间有性别和年龄段差异（U=2.599，4.368，均P＜0.01）。在3～6岁年龄段，随年龄增长RBC，Hb，HCT的基础水平有逐渐增高的趋势，同时男童的RBC，Hb，MCHC，RDW-CV总体基数水平则高于女孩。且与行业标准的参考区间均存在不同程度差别。同时验证通过新建的参考区间。结论不同地区学龄前期儿童RBC及其相关参考区间存在差异，建立适合攀枝花地区特殊人群的参考区间是必要的。
Abstract:
Objective The reference interval of venous whole blood red cells and related parameters of healthy children preschool stage 3 to 6 years in Panzhihua was established to provide practical experimental basis for pediatric clinical diagnosis and treatment. Methods From January to July 2023，1 467 eligible healthy children from 3 to 6 years old for physical examination were collected as study subjects，including 762 boys and 705 girls. Red blood cell (RBC), hemoglobin (Hb)，hematocrit (HCT)，mean red blood cell volume (MCV), mean corpuscular hemoglobin (MCH)，mean corpuscular hemoglobin concentration (MCHC) and red cell volume distribution width (RDW) were measured by Sysmex XN-1000 automatic blood analyzer. According to sex and age groups，the differences of the above indexes between different gender and age groups were compared，and the reference interval of venous whole blood red cells and related parameters of healthy children aged 3 to 6 years old in Panzhihua was established. At the same time，25 samples(including 13 boys and 12 girls) were selected to verify the newly established reference interval. Results HCT and RDW-SD reference intervals between boys and girls preschool stage 3～6 in the Panzhihua area ，and the differences were not statistically significant (U=0.000， 0.795, all P>0.05). The reference intervals for RBC, MCV, MCH and RDW-CV show statistically significant differences between boys and girls（U=2.829 ~ 5.753，all P＜0.05）. There were gender and age differences in the reference intervals of Hb and MCHC（U=2.599, 4.368, all P＜0.01）.In the 3～6 years, the basal levels of RBC, HGB and HCT tended to increase gradually with age, while the overall base levels of RBC, HGB, MCHC, and RDW-CV in boys were higher than those in girls. And there were different degrees of difference with the reference range of industry standards. Also verify through the new reference interval. Conclusion With differences in RBC and related reference intervals of preschool stage children in different regions, it is necessary to establish a reference interval suitable for special population in Panzhihua.

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备注/Memo

备注/Memo:
作者简介：李家明(1965-)，男，本科，主任技师，主要从事临床血液学研究，E-mail:706714508@qq.com。
更新日期/Last Update: 2025-09-15